"Common Platform Technology, Facilities, and Equipment" mission area: Full-scale R&D Project


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Four-Dimensional Topological Data Analysis for Future Medical Care


We shall establish a new methodology of data analysis, called "Four-dimensional topological data analysis (4d-TDA)", tracking the time evolution of geometric structures in various data with mathematically rigorously. In particular, applying 4d-TDA to issues in the fields of medicine and drug development, we shall contribute to a realization of a future society providing high-quality medical care to everyone at a lower cost. 

4d-TDA consists of topological flow data analysis (TFDA) and persistent homology (PH) combined with data-driven mathematical modeling.

Our research objectives are:

  • Creating a new classification for cardiovascular diseases based on blood flow structures in the heart; developing a software applicable to clinical diagnosis with echocardiography and MRI.
  • Designing conditions for effective clinical trials, which reduces the time and the number of participants, for antiviral drugs against infectious disease such as COVID-19 by predicting dynamics of biomarkers.
  • Establishing a common platform that provides mathematical solutions to many problems in human society.

R&D Team

[Leading Institution]
Kyoto University

Nagoya University, Cardio Flow Design Inc.,
National Institute of Infectious Disease

* This project is launched by integrating the following feasibility studies;
"Quantitative approach for genome evolution dynamics based on multiscale mathematical mode" (IWAMI Shingo) and "Comprehensive R&D Platform for Topological Data Analysis" (SAKAJO Takashi)

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