科学技術振興機構 さきがけ エピジェネティクスの制御と生命機能 エピジェネティクスの制御と生命機能さきがけ独立行政法人科学技術振興機構

研究成果

伊川　友活 （Tomokatsu Ikawa)

（corresponding author に＊印をしています。）

原著欧文論文

 

  1. Shibata K, Yamada H, Sato T, Dejima T, Nakamura M, Ikawa T, Hara H, Yamasaki S, Kageyama R, Iwakura Y, Kawamoto H, Toh H, Yoshikai Y. Notch-Hes1 pathway is required for the development of IL-17-producing gd T cells. Blood 118; 586-593, 2011
  2. Ikawa T, Hirose S, Masuda K, Kakugawa K, Satoh R, Shibano-Satoh A, Kominami R,Katsura Y, and Kawamoto H. An essential developmental checkpoint for production of the T cell lineage. Science 329: 93-96, 2010
  3. Hirose K, Inukai T, Kikuchi J, Furukawa Y, Ikawa T, Kawamoto H, Oram SH, Gottgen B, Kiyokawa N, Miyagawa Y, Okita H, Akahane K, Zhang X, Kuroda I, Nonna H, Kagami K, Goi K, Kurosawa H, Look AT, Matsui H, Inaba T and Sugita K. Aberrant induction of LMO2 theE2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19). Blood 116: 962-970, 2010
  4. Oguro H, Jin Y, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H, Nakauchi H, and Iwama A. Poised lineage specification in multipotent hematopoietic progenitor cells by the polycomb protein Bmi1. Cell Stem Cell 6: 279-286, 2010
  5. Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, Kawamoto H, Fujiwara J-I, Ohtani M, Fujii H, and Koyasu S. Innate production of Th2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphocytes. Nature 463: 540-544, 2010
  6. Higashi AY, Ikawa T, Muramatsu M, Ecnomides AN, Niwa A, Okuda T, Murphy AJ, Rojas J, Heike T, Nakahata T, Kawamoto H, Kita T, and Yanagita M. Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2. J. Immunol. 182:5633-5640, 2009
  7. Masuda K, Germeraad WTV, Satoh R, Itoi M, Ikawa T, Minato M, Katsura Y, W. van Ewijk, and Kawamoto H. Notch activation in thymic epithelial cells induces development of thymic microenvironments. Mol. Immunol. 46: 1756-1767, 2009
  8. Komaniwa S, Hayashi H, Kawamoto H, Ikawa T, Sato SB, Katsura Y, and Udaka K. Lipid-mediated presentation of MHC class II molecules guides thymocytes to the CD4 lineage. Eur. J. Immunol. 39: 96-122, 2009
  9. Yano M, Kuroda N, Han H, Horike M, Nishimura Y, Kiyonari H, Maemura K, Yanagawa Y, Obata K, Takahashi S, Ikawa T, Satoh R, Kawamoto H, Muroi Y, and Matsumoto M. Aire controls the differentiation of thymic epithelial cells in the medulla for the establishment of self-tolerance. J. Exp. Med. 205: 2877-2838, 2008
  10. Minami Y, Stuart SA, Ikawa T, Jiang Y, Banno A, Hunton IC, Young DJ, Naoe T, Murre C, Jamieson CH, and Wang JY. BCR-ABL-transformed GMP as myeloid leukemic stem cells. PNAS.105: 17967-17972, 2008
  11. Muroi S, Naoe Y, Miyamoto C, Akiyama K, Ikawa T, Masuda K, Kawamoto H, and Taniuchi I. Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate. Nature Immunol. 9: 1113-1121, 2008
  12. Ko, J, Patel N, Ikawa T, Kawamoto H, Frank O, Rivera R, van Etten RA, and Murre C. Id2 deficient mice develop myeloproliferative disorder whereas forced Id2 expression interferes with the development of BCR/ABL induced myloid leukemia. PNAS. 105: 12967-12972, 2008
  13. Wada H, Masuda K, Satoh R, Kakugawa K, Ikawa T, Katsura Y and Kawamoto H. Adult T cell progenitors retain myeloid potential. Nature 452: 768-772, 2008
  14. Agata, Y, Tamaki N, Sakamoto S, Ikawa T, Masuda K, Kawamo H, and Murre C. Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47. Immunity 27: 871-884, 2007
  15. Fujimoto S, Ikawa T, Kina T, and Yokota Y. Forced expression of Id2 in fetal thymic T cell progenitors allows some of their progeny to adopt NK cell fate. Int Immunol. 10: 1175-1182, 2007
  16. Ikawa T, Kawamoto H, Goldrath AW., and Murre C. E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment. J. Exp. Med. 203:1329-1342, 2006
  17. Masuda K, Kubagawa H, Ikawa T, Chen Ching-Cheng, Kubagawa K, Hattori M, Kageyama R, Cooper MD, Minato N, Katsura Y, and Kawamoto H. Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors. EMBO J. 24: 4052-4060, 2005
  18. Kawabata N, Kishimoto H, T Abe, Ikawa T, Yamanaka K, Ikeuchi H, and Kakimoto C. Control of tomatobacterial wilt without disinfection using a new functional polymer that catures microbial cells alive on the surface and is highly biodegradable. Biosci Biotechnol Biochem. 69: 326-333, 2005
  19. Maier H, Ostraat R, Gao H, Fields S, Shinton SA, Medina KL, Ikawa T, Murre C, Singh H, Hardy RR, and Hagman J. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nature Immunol. 10:1069-1077, 2004
  20. Ikawa T, Kawamoto H, Wright LYT, and Murre C. Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent. Immunity 20: 349-360, 2004
  21. Ikawa T, Masuda K, Min L, Minato N, Katsura Y, and Kawamoto H. Identification of the earliest prethymic T-cell progenitors in murine fetal blood. Blood 103: 530-537, 2004
  22. Kawamoto H., Ohmura K, Fujimoto S, Min L, Ikawa T, and Katsura Y. Extensive proliferation of T cell lineage-restricted progenitors in the thymus: essential process for clonal expression of diverse T cell receptor b chains. Eur. J. Immunol. 33: 606-615, 2003
  23. Shen HQ, Lu M, Ikawa T, Masuda K, Ohmura K, Minato N, Katsura Y, and Kawamoto H. T/NK bipotent progenitors in the murine thumus retain the potential to generate dendritic cells. J. Immunol. 171: 3401-3406, 2003
  24. Lu M, Kawamoto H, Katsube Y, Ikawa T, and Katsura Y. The common myelolymphoid progenitor: A key intermediate stage in hemopoiesis generating T and B cells. J. Immunol. 169: 3519-3525, 2002
  25. Ikawa T, Fujimoto S, Kawamoto H, Katsura Y, and Yokota Y. Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2. PNAS. 98: 5164-5169, 2001
  26. Ohmura K, Kawamoto H, Min L, Ikawa T, Ozaki S, Nagao K, and Katsura Y. Immature multipotent hematopoietic progenitors lacking bone marrow repopulating activity in the aorta-gonad-mesonephros region of murine day 10 fetuses. J. Immunol. 166: 3290-3296, 2001
  27. Kawamoto H, Ikawa T, Ohmura K, Fujimoto S, and Katsura Y. T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver. Immunity 12: 441-450, 2000
  28. Ikawa T, Kawamoto H, Fujimoto S, and Katsura Y. Commitment of T/Natural killer (NK) progenitors to unipotent T and NK progenitors in the murine fetal thumus revealed by a single progenitor assay. J. Exp. Med. 190: 1617-1625, 1999
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総説

  1. 伊川友活, 河本宏. T細胞運命決定マスター遺伝子の同定. 感染・炎症・免疫 41:81-83, 2011
  2. 伊川友活, 河本宏. 転写因子Bcl11bによるT細胞分化チェックポイント. 医学のあゆみ 236:864-866, 2011
  3. 伊川友活, 河本宏. 転写因子Bcl11bはT細胞系列への運命決定に必須である.実験医学 28:3123-3126, 2010
  4. Kawamoto H, Ikawa T, Masuda K, Wada H and Katsura Y. A map for lineage restriction of progenitors during hematopoiesis: the essence of the myeloid-based model. Immunol Rev. 238: 23-26, 2010
  5. 伊川友活，Cornelis Murre, 河本　宏．B細胞系列への決定とE2A. 免疫2005 41: 30-38,2004
  6. 伊川友活，河本　宏，桂　義元．NK細胞系列決定におけるId2の役割．臨床免疫　37:284-290, 2002
  7. 伊川友活，河本　宏，桂　義元．T/NK共通の前駆細胞からT細胞あるいはNK細胞への系列決定．臨床免疫　33: 282-289. 2000
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招待講演

  1. 第２０回東京免疫フォーラム　２０１１年２月２２日　東京伊川　友活「T細胞系列への運命決定を制御する分子機構」
  2. 第１１４回小児血液腫瘍懇話会　２０１０年１０月２９日　東京
    伊川　友活、広瀬　哲史、木南　凌、
    桂　義元、河本　宏「転写因子Bcl11bによるT細胞系列への運命決定」
  3. JSI-RCAI Workshop 2007「転写因子とTリンパ球分化」　２００７年３月７日　神奈川
    Ikawa T, Goldrath AW, Murre C, and Kawamoto H. "Roles of E2A in lymphoid lineage commitment"
  4. 第２８回日本分子生物学会年会ワークショップ「免疫細胞の運命決定機構」　２００５年１２月８日　福岡
    Ikawa T, Kawamoto H, Mercer E M, Goldrath AW, and Murre C. "Molecular networks regulated by E-proteins and Notch signaling in lymphoid lineage specification"