科学技術振興機構 さきがけ エピジェネティクスの制御と生命機能 エピジェネティクスの制御と生命機能さきがけ独立行政法人科学技術振興機構

研究成果

長谷 耕二 (Koji Hase)

原著欧文論文

 

  1. Kanaya T, Hase K, Takahashi D, Fukuda S, Hoshino K, Sasaki I, Hemmi H, Knoop KA, Kumar N, Sato M, Katsuno T, Yokosuka O, Toyooka K, Nakai K, Sakamoto A, Kitahara Y, Jinnohara T, McSorley SJ, Kaisho T, Williams IR and Ohno H, The Ets Transcription factor Spi-B is essential for the differentiation of intestinal microfold (M) Cells. Nat. Immunol. 13: 729-736, 2012.
  2. Ouchida R, Mori H, Hase K, Takatsu H, Kurosaki T, Tokuhisa T, Ohno H and Wang J-Y, Critical role of the IgM Fc receptor in IgM homeostasis, B-cell survival, and humoral immune responses. Proc. Natl. Acad. Sci. USA., 109: E2699-706..
  3. Obata Y, Takahashi D, Ebisawa M, Kakiguchi M, Yonemura S, Jinnohara T, Kanaya T, Fujimura Y, Ohmae M, Hase K and Ohno H. Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis. J. Immunol. 188: 2427-36, 2012.
  4. Mimura M, Masuda A, Nishiumi S, Kawakami K, Fujishima Y, Yoshie T, Mizuno S, Miki I, Ohno H, Hase K, Minamoto T, Azuma T and Yoshida M, AP1B plays an important role in intestinal tumorigenesis with the truncating mutation of an APC gene. Int. J. Cancer 130: 1011-20, 2012.
  5. Takahashi D, Hase K, Kimura S, Nakatsu F, Ohmae M, Mandai Y, Sato T, Date Y, Ebisawa M, Kato T, Obata Y, Fukuda S, Kawamura Y. I, Dohi T, Katsuno T, Yokosuka O, Waguri S and Ohno H. The Epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice. Gastroenterology 141: 621-32, 201
  6. Ebisawa M, Hase K, Takahashi D, Kitamura H, Knoop KA, Williams IR, *Ohno H. CCR6hiCD11cint B cells promote M-cell differentiation in Peyer's patch. Int. Immunol. 23: 261-9, 2011.
  7. Ito M, Kitamura H, Kikuguchi C, Hase K, Ohno H and Ohara O, SP600125 inhibits cap-dependent translation independently of the c-Jun N-terminal kinase pathway. Cell Struct. Funct. 36: 27-33, 2011.
  8. Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DM, Suzuki T, Taylor TD, Itoh K, Kikuchi J, Morita H, Hattori M, Ohno H. Bifidobacteria protect host from enteropathogenic infection through production of acetate. Nature, 469: 543-547, 2011
  9. Shima H, Takatsu H, Fukuda S, Ohmae M, Hase K, Kubagawa H, Wang JY, *Ohno H. Identification of TOSO/FAIM3 as an Fc receptor for IgM. Int. Immunol. 22: 149-56, 2010.
  10. Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K, Tobe T, Fujimura Y, Kawano S, Yabashi A, Waguri S, Nakato G, Kimura S, Murakami T, Iimura M, Hamura K, Fukuoka S, Lowe AW, Itoh K, Kiyono H, Ohno H. Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response. Nature. 462: 226-30, 2009.
  11. Hase K, Kimura S, Takatsu H, Ohmae M, Kawano S, Kitamura H, Ito M, Watarai H, Hazelett CC, Yeaman C, Ohno H. M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex. Nat. Cell Biol. 11: 1427-32, 2009.
  12. Nakato G, Fukuda S, Hase K, Goitsuka R, Cooper MD, Ohno H. New approach for M-cell-specific molecules screening by comprehensive transcriptome analysis. DNA Res. 16: 227-235, 2009.
  13. Terashima A, Watarai H, Inoue S, Sekine E, Nakagawa R, Hase K, Iwamura C, Nakajima H, Nakayama T and TaniguchiM, A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity. J. Exp. Med. 205: 2727-33, 2008.
  14. Zhu G, Okada M, Yoshida N, Ueno S, Mori F, Takahara T, Saito R, Miura Y, Kishi A, Tomiyama M, Sato A, Kojima T, Fukuma G, Wakabayashi K, Hase K, Ohno H, Kijima H, Takano Y, Mitsudome A, Kaneko S, and Hirose S. Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype. J. Neuroscience 28:12465-76, 2008.
  15. Hase K, Takahashi D, Ebisawa M, Kawano S, Itoh K and Ohno H. Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease. PLoS ONE 3: e3033, 2008.
  16. Terahara K, Yoshida M, Igarashi O, Nochi T, Pontes GS, Hase K, Ohno H, Kurokawa S, Mejima M, Takayama N, Yuki Y, Lowe AW, Kiyono H. Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J Immunol. 180: 7840-6, 2008.
  17. Dann SM, Spehlmann ME, Hammond DC, Iimura M, Hase K, Choi LJ, Hanson E, Eckmann L. IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens. J Immunol. 180: 6816-26, 2008.
  18. Kamijuku H., Nagata Y., Jiang X., Ichinohe T., Tashiro T., Mori K., Taniguchi M., Hase K, Ohno H., Shimaoka T., Yonehara S., Odagiri T., Tahiro M., Sata T., Hasegawa H., Seino K-i. Mechanism of NKT cell activation by intranasal coadministration of α-galactosylceramide, which can induce cross-protection against influenza. Mucosal Immunol. 1(3): 208-218, 2008
  19. Hijikata A, Kitamura H, Kimura Y, Yokoyama R, Aiba Y, Bao Y, Fujita S, Hase K, Hori S, Kanagawa O, Kawamoto H, Kawano K, Koseki H, Kubo M, Kurita Miki A, Kurosaki T, Masuda K, Nakata M, Oboki K, Ohno H, Okamoto M, Okayama Y, O-Wang J, Saito H, Saito T, Sakuma M, Sato K, Sato K, Seino KI, Setoguchi R, Tamura Y,Tanaka M, Taniguchi M, Taniuchi I, Teng A, Watanabe T, Watarai H, Yamasaki S, Ohara O., Construction of an open-access database that integrates cross-reference information from the transcriptome and immune cells. Bioinformatics, 23: 2934-41. 2007
  20. Kawano K, Ebisawa M, Hase K, Fukuda S, Hijikata A, Kawano S, Date Y, Itoh K and Ohno H, Psg18 is specifically expressed in follicle-associated epithelium. Cell Struct. Funct. 32: 115-26, 2007.
  21. Murakami T, Chen X, Hase K, Sakamoto A, Nishigaki C, Ohno H. Splenic CD19-CD35+B220+ cells function as an inducer of follicular dendritic cell network formation. Blood 110: 1215-24, 2007.
  22. Takatsu H, Hase K, Ohmae M, Ohshima S, Hashimoto K, Taniura N, Yamamoto A and Ohno H. CD300 antigen like family member G: A novel Ig receptor like protein exclusively expressed on capillary endothelium. Biochem Biophys Res Commun. 348: 183-191, 2006.
  23. Takano-Maruyama M, Hase K, Fukamachi H, Kato Y, Koseki H and Ohno H, Foxl1-deficient mice exhibit aberrant epithelial cell positioning due to dysregulated EphB/EphrinB expression in the small intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 291: G163-G170, 2006.
  24. Hase K, Murakami T, Takatsu T, Shimaoka T, Iimura M, Hamura K, Kawano K, Ohshima S, Chihara R, Itoh K, Yonehara S and Ohno H, The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT. J. Immunol. 176: 43-51, 2006.
  25. Hase K, Ohshima S, Kawano K, Hashimoto N, Matsumoto K, Saito H and Ohno H, Distinct gene expression profiles characterize cellular phenotypes of follicle-associated epithelium and M cells. DNA Res. 12: 127-137, 2005.
  26. Iimura M, Gallo RL, Hase K, Miyamoto Y, Eckmann L and Kagnoff MF, Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens. J. Immunol. 174: 4901-4907, 2005.
  27. Hase K, Murakami M, Iimura M, Cole SP, Horibe Y, Ohtake T, Obonyo M, Gallo RL, Eckmann L, and Kagnoff MF, Expression of LL-37/hCAP18 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori. Gastroenterology, 125: 1613-1625, 2003.
  28. Hase K, Eckmann L., Leopard JD, Varki N and Kagnoff MF, Cell differentiation is a key determinant of cathelicidin LL-37/hCAP18 expression by human colon epithelium. Infection immunity 70: 953-963, 2002.
  29. Kasaoka S, Hase K, Morita T and Kiriyama S, Green tea flavonoids inhibit the LDL oxidation in osteogenic disordered rats fed a marginal ascorbic acid in diet. J. Nutr. Biochem 13: 96-102, 2002.
  30. Xiong Q, Tezuka Y, Kaneko T, Li H, Tran LQ, Hase K, Namba T and Kadota S, Inhibition of nitric oxide by phenylethanoids in activated macrophages. Eur. J. Pharmacol. 400:137-44, 2000.
  31. Banskota AH, Tezuka Y, Adnyana IK, Xiong Q, Hase K, Tran KQ, Tanaka K, Saiki I and Kadota S, Hepatoprotective effect of Combretum quadrangulare and its constituents. Biol. Pharm. Bul. 23: 456-60, 2000.
  32. Xiong Q, Hase K, Tezuka Y, Namba T and Kadota S, Acteoside inhibits apoptosis in D-Galactosamine and lipopolysaccharide-induced liver injury. Life Science 65: 421-430, 1999.
  33. Hase K, Xiong Q, Basnet P, Namba T and Kadota S, Inhibitory effect of tetrahydroswertianolin on TNF・dependent hepatic apoptosis in mice. Biochem Pharmacol 57: 1431-1437, 1999.
  34. .Morita T, Kasaoka S, Hase K, Kiriyama S, Psyllium shifts the fermentation site of high-amylose cornstarch toward the distal colon and increases fecal butyrate concentration in rats. J Nutr 129: 2081-2087, 1999.
  35. Morita T, Kasaoka S, Hase K, Kiriyama S, Oligo-L-methionine and resistant protein promote cecal butyrate production in rats fed resistant starch and fructooligosaccharide. J Nutr 129: 1333-1339, 1999.
  36. Ohsugi M, Fan W, Hase K, Xiong Q, Tezuka K, Komatsu K, Namba T, Saitoh T, Tazawa K and Kadota S, Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra. J Ethnopharmacol 67:111-9, 1999.
  37. Watanabe C, Satoh T, Tahara E, Murakami K, Hayashi K, Hase K, Andoh T, Kuraishi Y, Kadota S, Nagai H and Saiki I, Inhibitory effect of glycoprotein fraction derived from Miscanthus sinensis for the immediate phase response of an IgE-mediated cutaneous reaction. Biol Pharm Bull 22: 26-30, 1999.
  38. Hayakawa Y, Fujii H, Hase K, Ohnishi Y, Sakukawa R, Kadota S, Namba T and Saiki I, Anti-metastatic and immunomodulating properties of the water extract from Celosia argentea seeds. Biol Pharm Bull 21: 1154-1159, 1998.
  39. Prasain JK, Tezuka Y, Hase K, Basnet P, Dong H, Namba T and Kadota S, Inhibitory effect of diarylheptanoids on nitric oxide production in activated murine macrophages. Biol Pharm Bull 21: 371-374, 1998.
  40. Watanabe C, Hase K, Oku T, Koizumi F, Kadota S, Nagai H, Namba T and Saiki I, Effect of spiklets of Miscanthus sinensis on IgE-mediated biphasic cutaneous reaction in mice. Planta Med 64: 12-17, 1998
  41. Xiong Q, Hase K, Tezuka Y, Tani T, Namba T and Kadota S, Hepatoprotective activity of phenylethanoids from Cistanche deserticola. Planta Med 64: 120-125, 1998.
  42. Hase K, Ohsugi M, Xigong Q, Basnet P, Kadota S and Namba T, Hepatoprotective effect of Hovenia dulcis Thunb. on experimental liver injuries induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide. Biol Pharm Bull 20: 381-385, 1997.
  43. Hase K, Kadota S, Basnet P, Li J, Xiong Q, Takamura S and Namba T, Hepatoprotective principles of Swertia japonica Makino on D-galactosamine/lipopolysaccharide-induced liver injury in mice. Chem Pharm Bull 45: 1823-1827, 1997.
  44. Hase K, Kadota S, Basnet P, Li J, Takamura S and Namba T, Tetrahydroswertianolin: A potent hepatoprotective agent from Swertia japonica. Chem Pharm Bull 45: 567-569, 1997.
  45. Hase K, Basnet P, Kadota S and Namba T, Immunostimulating activity of celosian, an antihepatotoxic polysaccharide isolated from Celosia argentea. Planta Med 63: 216-219, 1997.
  46. Hase K, Basnet P, Kadota S and Namba T, Effect of Hovenia dulcis on lipopolysaccharide-induced liver injury in chronic alcohol-fed rats. J Trad Med 14: 28-33, 1997.
  47. Basnet P, Matsushige K, Hase K, Kadota S and Namba T, Four di-O-caffeoyl quinic acid derivatives from propolis. Potent hepatoprotective activity in experimental liver injury models. Biol Pharm Bull 19: 1479-1484, 1996.
  48. Basnet P, Matsushige K, Hase K, Kadota S, Namba T, Potent antihepatotoxic activity of dicaffeoyl quinic acids from propolis. Biol Pharm Bull 19: 655-657, 1996.
  49. Matsushige K, Basnet P, Hase K, Kadota S, Tanaka K and Namba T, Propolis protects pancreatic beta-cells against the toxicity of streptozotocin (STZ). Phytomedicine 3: 203-209, 1996.
  50. Prasain JK, Kadota S, Basnet P, Hase K and Namba T, Hepatoprotective effects of Panax notoginseng: Ginsenosides-Re and -Rg1 as its active constituents in D-galactosamine/lipopolysaccharide-induced liver injury. Phytomedicine 2: 297-303, 1996.
  51. Hase K, Kasimu R, Basnet P, Kadota S and Namba T, Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide. Planta Med 63: 22-26, 1997.
  52. Hase K, Kadota S, Basnet P, Takahashi T and Namba T, Protective effect of celosian, an acidic polysacchride, on chemically and immunologically induced liver injuries. Biol Pharm Bull 19: 567-572, 1996
  53. Hase K, Kadota S, Basnet P, Namba T and Takahashi T, Hepatoprotective effects of traditional medicines. Isolation of the active constituent from seeds of Celosia argentea. Phytother Res 10: 387-392, 1996.
  54. Iida K, Hase K, Shimomura K, Sudo S, Kadoata S and Namba T, Potent inhibitors of tyrosinase activity and melanin biosynthesis from Rheum officinale. Planta Med 61: 425-428, 1995.
  55. Basnet P, Kadota S, Hase K and Namba T, Five new C-methyl flavonoids, the potent aldose reductase inhibitors from Matteuccia orientalis Trev. Chem Pharm Bull 43: 1558-1564, 1995.
  56. Kadota S, Basnet P, Hase K and Namba T, Matteuorienate A and B, two new and potent aldose reductase inhibitors from Matteuccia orientalis (Hook.) Trev. Chem Pharm Bull 42: 1712-1714, 1994.
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総説

  1. Ohno H, Hase K and Kimura S. M-Sec, a key molecule for tunneling nanotubule formation. Communicat. Integrat. Biol., in press
  2. 長谷耕二,大野博司
    Glycoprotein 2(GP2)によるI型繊毛を有する細菌のM細胞特異的な取り込み. 実験医学,2010年3月号.
  3. 長谷耕二, 大野博司.
    腸管特殊上皮M細胞による抗原トランスサイトーシスの分子機構. 蛋白質 核酸 酵素・増刊「メンブラントラフィックの奔流」 53 (16) 2274-8, 2008.
  4. 大野博司, 長谷耕二, 中津史
    クラスリン輸送小胞の制御因子AP複合体の生理機能. 蛋白質 核酸 酵素・増刊「メンブラントラフィックの奔流」 53 (16) 2158-63, 2008.
  5. 長谷耕二
    M細胞を介した病原体侵入機構. 感染・炎症・免疫 38: 64-65. 2008.
  6. 長谷耕二
    Tunneling nanotubule (TNT)と免疫細胞間相互作用. 生体の科学 59: 302-306, 2008.
  7. 大野博司, 長谷耕二, 河野和也
    M細胞による抗原の認識・取り込みとそのレセプター. 臨床免疫・アレルギー科 49: 1-9, 2008.
  8. 大野博司, 長谷耕二
    粘膜免疫系のポータルサイト,FAEとM細胞.実験医学増刊・「免疫研究最前線2007」24: 3112-3121, 2006.
  9. 長谷耕二. CXCL16は粘膜免疫系におけるリンパ−上皮間相互作用を促進する.臨床免疫・アレルギー科 46: 213-216, 2006.
  10. 長谷耕二. 大野博司
    粘膜免疫系における上皮細胞の生体防御機構.日本臨床免疫学会誌 29:16-26, 2006.
  11. Hase K, Xiong Q and Kadota S, Hepatoprotective effect of plant components: Inhibitoon of tumor necrosis factor・dependent inflammatory liver injury. Studies in Natural Product Chemistry 25: 459-482, 2001.
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招待講演

  1. Hase K, Antigen transcytosis by M cells: from molecular entities to biological significance. 4th Symposium of Immunology Frontier Research Center (IFReC). June 1-2, 2010, Osaka, Japan.
  2. Hase K and Ohno H, M-Sec promotes intercellular logistics via membrane nanotube formation. 第62回日本細胞生物学会大会.2010年5月19-21日,大阪
  3. 長谷耕二
    生体フロントラインバリアの構築に果たす上皮特異的極性輸送因子AP-1Bの役割. 第14回IBD若手研究者の会.2010年4月1日,新潟
  4. Hase K, GP2-dependent antigen transcytosis by M cells initiates mucosal immune response. The 4th Stage Surface Barrier Immunology Study Group (SBARIS). 2nd Meeting. January 29-30, 2010, Tokyo.
  5. Hase K, Kawano K, Kiyono H., Ohno H. GP2-dependent antigen transcytosis by M cells initiates mucosal immune response. 第39回日本免疫学会・国際シンポジウム2009年12月2-4日,大阪
  6. 長谷耕二
    粘膜免疫系の最前線におけるM細胞依存的抗原取り込み機構の解明. 日本食品免疫学会シンポジウム.2009年5月27日, 東京
  7. 長谷耕二
    腸管特殊上皮M細胞による抗原トランスサイトーシスの分子機構. 第13回日本食物繊維学会学術集会 2008年11月21-22日, 東京
  8. Hase K, Function and differentiation of intestinal follicular M cells. The 3rd JSI-RCAI Immunology Workshop. March 14, 2008, Yokohama
  9. 長谷耕二
    粘膜免疫系のポータルサイト・M細胞を介した免疫監視機構.第17回東京免疫フォーラム(17th Molecular Immunology Forum)2008年3月11日,東京
  10. Hase K, M-Sec regulates tunneling nanotubule (TNT) formation in intestinal M cells. 第37回日本免疫学会・国際シンポジウム2007年11月20-22日,東京
  11. 長谷耕二
    腸管特殊上皮M細胞による粘膜抗原トランスサイトーシス機能の解析.第12回Hindgut Club Japanシンポジウム.2006年12月2日, 東京
  12. Hase K, Differentiation and function of intestinal M cells. The 3rd Stage Surface Barrier Immunology Study Group (SBARIS) 3rd Meeting. October 27-28, 2006, Miyazaki
  13. Hase K, Function and gene expression profile of intestinal specialized epithelium M cells. The 10th International Symposium on Traditional Medicine in Toyama 2005. July 14-15, 2005, Toyama.