科学技術振興機構 さきがけ エピジェネティクスの制御と生命機能 エピジェネティクスの制御と生命機能さきがけ独立行政法人科学技術振興機構

研究成果

西岡　憲一 （Kenichi Nishioka)

著書

  1. 西岡憲一ヒストンメチル化活性測定 in エピジェネティクス実験プロトコール 牛島俊和・眞貝洋一編 羊土社 2008;181-189.
  2. 西岡憲一 メチル化ヒストンによるクロマチン構造のエピジェネティック制御機構 in エピジェネティクス 佐々木裕之編 シュプリンガーフェアラーク東京 2004;31-50.

論文

  1. Nakayama T, Nishioka K, Dong YX, Shimojima T, Hirose S. Drosophila GAGA factor directs histone H3.3 replacement that prevents the heterochromatin spreading. Genes Dev. 2007;21:552-561.
  2. Nishioka K, Hirose S. Epigenetic regulations of chromatin dynamics: A role of noncoding RNAs in epigenetic activation of Drosophila Hox genes. in Radiation risk perspectives. International Congress Series No.1299. (ed: Shibata Y, Namba H, Suzuki K, Tomonaga M) Elsevier B.V. 2007;239-241.
  3. Sarma K, Nishioka K, Reinberg D. Tips in analyzing antibodies directed against specific histone tail modifications. Methods Enzymol. 2004;376:255-269.
  4. Nishioka K, Reinberg D. Methods and tips for the purification of human histone methyltransferases. Methods. 2003;31:49-58.
  5. Sims RJ 3rd, Nishioka K, Reinberg D. Histone lysine methylation: a signature for chromatin function. Trends Genet. 2003;19:629-639.
  6. Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 2002;16:2893-2905.
  7. Rice JC#, Nishioka K#, Sarma K, Steward R, Reinberg D, Allis CD. Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev. 2002;16:2225-2230. (#: equal contribution)
  8. Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, Reinberg D. PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell. 2002b;9:1201-1213.
  9. Nishioka K, Chuikov S, Sarma K, Erdjument-Bromage H, Allis CD, Tempst P, Reinberg D. Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev. 2002a;16:479-489.

総説

  1. Reinberg D, Chuikov S, Farnham P, Karachentsev D, Kirmizis A, Kuzmichev A, Margueron R, Nishioka K, Preissner TS, Sarma K, Abate-Shen C, Steward R, Vaquero A. Steps toward understanding the inheritance of repressive methyl-lysine marks in histones. Cold Spring Harb Symp Quant Biol. 2004;69:171-182.
  2. 西岡憲一 Getting Derepressed!: Hox遺伝子群におけるエピジェネティック制御の新展開 細胞工学 2004;23:1155-1161.
  3. 西岡憲一 エピジェネティック制御機構におけるメチル化ヒストンの役割 実験医学 2004;22:1361-1370.
  4. 西岡憲一 ヒストンH4リジン20のメチル化によるクロマチン高次構造の制御 細胞工学 2003;22:669-674.
  5. Nishioka K, Reinberg D. Transcription. Switching partners in a regulatory tango. Science. 2001;294:2497-2498.

国際学会

  1. Higashimoto K, Yada Y, Komori T, Matsuda M, Koseki Y, Nakayama M, Handa H, Soejima H, Koseki H, Hirose S, Nishioka K. Histone methylation by mammalian ASH1L facilitates induction of Hox genes in response to retinoic acid, thereby contributes to acquisition of proper identities of cervical vertebrae. Poster session at the Cold Spring Harbor Meeting on Mechanism of Eukaryotic Transcription. Cold Spring Harbor, New York, 2009.
  2. Nishioka K, Rice JC, Sarma K, Chuikov S, Erdjument-Bromage H, Tempst P, Steward R, Allis CD, Reinberg D. Regulation of chromatin organization by human HMTs; characterization of human H3-K4 and H4-K20-specific HMTs. Poster Session at the Keystone Symposia on Chromatin Structure abd Function, Santa Fe, New Mexico, 2002.