科学技術振興機構 さきがけ エピジェネティクスの制御と生命機能 エピジェネティクスの制御と生命機能さきがけ独立行政法人科学技術振興機構

研究成果

岩本　和也 （Kazuya Iwamoto)

（corresponding author に＊印をしています。）

原著欧文論文

 

  1. Kato T*, Hayashi-Takagi A, Toyota T, Yoshikawa T, Iwamoto K*. Gene expression analysis in lymphoblastoid cells as a potential biomarker of bipolar disorder. Journal of Hum Genet in press
  2. Sugawara H, Iwamoto K, Bundo M, Ueda J, Miyauchi T, Komori A, Kazuno AA, Adati N, Kusumi I, Okazaki Y, Ishigooka J, Kojima T, Kato T*. Hypermethylation of serotonin transporter gene in bipolar disorder detected by epigenome analysis of discordant monozygotic twins. Translational Psychiatry 　2011,1:e24.
  3. Yamada K, Iwayama Y, Hattori E, Iwamoto K, Toyota T, Ohnishi T, Ohba H, Maekawa M, Kato T, Yoshikawa T*. Genome-wide association study of schizophrenia in Japanese population. PLoS One　2011,6:e20468.
  4. Iwamoto K*, Bundo M, Ueda J, Oldham MC, Ukai W, Hashimoto E, Saito T, Geschwind DH, Kato T*. Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons. Genome Res　2011,21:688-696.
  5. Iwamoto K*, Ueda J, Bundo M, Kojima T, Kato T*. Survey of the effect of genetic variations on gene expression in human prefrontal cortex and its application to genetics of psychiatric disorders.Neurosci Res　2011,70:238-242.
  6. Sugawara H, Iwamoto K, Bundo M, Ueda J, Ishigooka J and Kato T*. Comprehensive DNA methylation analysis of human peripheral blood leukocytes and lymphoblastoid cell lines. Epigenetics　2011,6:508-515.
  7. Kubota M, Kasahara T, Iwamoto K, Komori A, Miyauchi T, Ishiwata M, Kato T*. Therapeutic implications of down-regulation of cyclophilin D in bipolar disorder. Int J Neuropsychopharmacol　2010,13:1355-1368.
  8. Sugawara H, Iwamoto K, Bundo M, Ishiwata M, Ueda J, Kakiuchi C, Ishigooka J, Kato T*. Effect of mood stabilizers on gene expression in lymphoblastoid cells. J Neural Transm　2010,117:155-164.
  9. Iwayama Y, Hattori E, Maekawa M, Yamada K, Toyota T, Ohnishi T, Iwata Y, Tsuchiya KJ, Sugihara G, Kikuchi M, Hashimoto K, Iyo M, Inada T, Kunugi H, Ozaki N, Iwata N, Nanko S, Iwamoto K, Okazaki Y, Kato T, Yoshikawa T*. Association analyses between brain-expressed fatty-acid binding protein (FABP) genes and schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet　2010,153B:484-493.
  10. Bundo M, Iwamoto K, Yamada K, Yoshikawa T, Kato T*. Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain. Psychiatry Clin Neurosci　2010,64:57-61.
  11. Washizuka S, Iwamoto K, Kakiuchi C, Bundo M, Kato T*. Expression of mitochondrial complex I subunit gene NDUFV2 in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia.Neurosci Res　2009,63:199-204.
  12. Sugawara H, Iwamoto K, Bundo M, Kazuno AA, Nakano Y, Ishigooka J, Kato T*. A 3-bp deletion of mitochondrial DNA tRNALys observed in lymphoblastoid cells. J Hum Genet　2009,54:612-613.
  13. Nakatani J, Tamada K, Hatanaka F, Ise S, Ohta H, Inoue K, Tomonaga S, Watanabe Y, Chung YJ, Banerjee R, Iwamoto K, Kato T, Okazawa M, Yamauchi K, Tanda K, Takao K, Miyakawa T, Bradley A, Takumi T*. Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell　2009,137:1235-1246.
  14. Tochigi M, Iwamoto K, Bundo M, Sasaki T, Kato N, Kato T*. Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains.Neurosci Res　2008,60:184-191.
  15. Tochigi M, Iwamoto K, Bundo M, Komori A, Sasaki T, Kato N, Kato T*. Methylation status of the reelin promoter region in the brain of schizophrenic patients. Biol Psychiatry　 2008,63:530-533.
  16. Oldham MC*, Konopka G, Iwamoto K, Langfelder P, Kato T, Horvath S, Geschwind DH*. Functional organization of the transcriptome in human brain. Nat Neurosci　2008,11:1271-1282.
  17. Kuratomi G, Iwamoto K, Bundo M, Kusumi I, Kato N, Iwata N, Ozaki N, Kato T*. Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins. Mol Psychiatry　2008,13:429-441.
  18. Kato T, Ishiwata M, Yamada K, Kasahara T, Kakiuchi C, Iwamoto K, Kawamura K, Ishihara H, Oka Y*. Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder.Neurosci Res　2008,61:143-158.
  19. Iwamoto K*, Ueda J, Bundo M, Nakano Y, Kato T. Effect of a functional single nucleotide polymorphism in the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene on the expression of oligodendrocyte-related genes in schizophrenia. Psychiatry Clin Neurosci　2008,62:103-108.
  20. Nakatani N, Ohnishi T, Iwamoto K, Watanabe A, Iwayama Y, Yamashita S, Ishitsuka Y, Moriyama K, Nakajima M, Tatebayashi Y, Akiyama H, Higuchi T, Kato T, Yoshikawa T*. Expression analysis of actin-related genes as an underlying mechanism for mood disorders. Biochem Biophys Res Commun　2007,352:780-786.
  21. Iwamoto K, Ueda J, Nakano Y, Bundo M, Ukai W, Hashimoto E, Saito T, Kato T*. Evaluation of whole genome amplification methods using postmortem brain samples. J Neurosci Methods　 2007,165:104-110.
  22. Iwamoto K*, Bundo M, Ueda J, Nakano Y, Ukai W, Hashimoto E, Saito T, Kato T. Detection of chromosomal structural alterations in single cells by SNP arrays: a systematic survey of amplification bias and optimized workflow. PLoS One　2007,2:e1306.
  23. Hayashi A, Kasahara T, Iwamoto K, Ishiwata M, Kametani M, Kakiuchi C, Furuichi T, Kato T*. The role of brain-derived neurotrophic factor (BDNF)-induced XBP1 splicing during brain development. J Biol Chem　2007,282:34525-34534.
  24. Kohda K*, Jinde S, Iwamoto K, Bundo M, Kato N, Kato T. Maternal separation stress drastically decreases expression of transthyretin in the brains of adult rat offspring. Int J Neuropsychopharmacol　2006,9:201-208.
  25. Iwamoto K, Bundo M, Yamada K, Takao H, Iwayama Y, Yoshikawa T, Kato T*. A family-based and case-control association study of SOX10 in schizophrenia. Am J Med Genet B Neuropsychiatr Genet　2006,141B:477-481.
  26. Iwamoto K*, Bundo M, Ueda J, Kato T. Expression of ribosomal subunit genes increased coordinately with postmortem interval in human brain. Mol Psychiatry　2006,11:1067-1069.
  27. Munakata K, Iwamoto K, Bundo M, Kato T*. Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia. Biol Psychiatry　2005,57:525-532.
  28. Kato T*, Iwayama Y, Kakiuchi C, Iwamoto K, Yamada K, Minabe Y, Nakamura K, Mori N, Fujii K, Nanko S, Yoshikawa T. Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia. Mol Psychiatry　2005,10:1045-1055.
  29. Kakiuchi C*, Ishiwata M, Kametani M, Nelson C, Iwamoto K, Kato T. Quantitative analysis of mitochondrial DNA deletions in the brains of patients with bipolar disorder and schizophrenia. Int J Neuropsychopharmacol　2005,8:515-522.
  30. Iwamoto K*, Nakatani N, Bundo M, Yoshikawa T, Kato T. Altered RNA editing of serotonin 2C receptor in a rat model of depression.Neurosci Res　2005,53:69-76.
  31. Iwamoto K*, Bundo M, Yamada K, Takao H, Iwayama-Shigeno Y, Yoshikawa T, Kato T. DNA methylation status of SOX10 correlates with its downregulation and oligodendrocyte dysfunction in schizophrenia. J Neurosci　2005,25:5376-5381.
  32. Iwamoto K†*, Bundo M†, Kato T. Estimating RNA editing efficiency of five editing sites in the serotonin 2C receptor by pyrosequencing. RNA　2005,11:1596-1603.
  33. Iwamoto K, Bundo M, Kato T*. Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum Mol Genet　2005,14:241-253.
  34. Huang YT, Iwamoto K, Kurosaki T, Nasu M, Ueda S*. The neuronal POU transcription factor Brn-2 interacts with Jab1, a gene involved in the onset of neurodegenerative diseases. Neurosci Lett　2005,382:175-178.
  35. Aoki-Suzuki M, Yamada K, Meerabux J, Iwayama-Shigeno Y, Ohba H, Iwamoto K, Takao H, Toyota T, Suto Y, Nakatani N, Dean B, Nishimura S, Seki K, Kato T, Itohara S, Nishikawa T, Yoshikawa T*. A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia. Biol Psychiatry　2005,57:382-393.
  36. Washizuka S, Iwamoto K, Kazuno AA, Kakiuchi C, Mori K, Kametani M, Yamada K, Kunugi H, Tajima O, Akiyama T, Nanko S, Yoshikawa T, Kato T*. Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigrees. Biol Psychiatry　2004,56:483-489.
  37. Iwamoto K, Kakiuchi C, Bundo M, Ikeda K, Kato T*. Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. Mol Psychiatry　2004,9:406-416.
  38. Iwamoto K, Bundo M, Yamamoto M, Ozawa H, Saito T, Kato T*. Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. Neurosci Res　2004,49:379-385.
  39. Iwamoto K, Bundo M, Washizuka S, Kakiuchi C, Kato T*. Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia. J Hum Genet　2004,49:227-231.
  40. Ide M, Muratake T, Yamada K, Iwayama-Shigeno Y, Iwamoto K, Takao H, Toyota T, Kaneko N, Minabe Y, Nakamura K, Kato T, Mori N, Asada T, Someya T, Yoshikawa T*. Genetic and expression analyses of FZD3 in schizophrenia. Biol Psychiatry　2004,56:462-465.
  41. Kato T, Iwamoto K, Washizuka S, Mori K, Tajima O, Akiyama T, Nanko S, Kunugi H, Kato N*. No association of mutations and mRNA expression of WFS1/wolframin with bipolar disorder in humans. Neurosci Lett　2003,338:21-24.
  42. Kakiuchi C, Iwamoto K, Ishiwata M, Bundo M, Kasahara T, Kusumi I, Tsujita T, Okazaki Y, Nanko S, Kunugi H, Sasaki T, Kato T*. Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder. Nat Genet　2003,35:171-175.
  43. Iwamoto K, Kato T*. RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders. Neurosci Lett　2003,346:169-172.
  44. Iwamoto K, Kato T*. Effects of cocaine and reserpine administration on RNA editing of rat 5-HT2C receptor estimated by primer extension combined with denaturing high-performance liquid chromatography. Pharmacogenomics J　2002,2:335-340.
  45. Iwamoto K, Huang Y, Ueda S*. Genomic organization and alternative transcripts of the human PQBP-1 gene. Gene　2000,259:69-73.
このページのTOPへ

英語総説など

  1. Iwamoto K*, Bundo M, Kasai K, Kato T. Measuring RNA editing of serotonin 2C receptor. Biochemistry (Moscow)　2011,76:912-914.
  2. Iwamoto K*, Bundo M, Kato T. (book chapter) RNA editing of serotonin 2C receptor and neuropsychiatric diseases. 5-HT2C receptors in the pathophysiology of CNS disease , Springer, Berlin　2010,157-167.
  3. Iwamoto K*, Kato T. Epigenetic profiling in schizophrenia and major mental disorders. Neuropsychobiology　2009,60:5-11.
  4. Iwamoto K*, Bundo M, Kato T. Serotonin receptor 2C and mental disorders: genetic, expression and RNA editing studies. RNA Biol　2009,6:248-253.
  5. Kato T*, Kakiuchi C, Iwamoto K. Comprehensive gene expression analysis in bipolar disorder. Can J Psychiatry　2007,52:763-771.
  6. Iwamoto K*, Kato T. Gene expression profiling in schizophrenia and related mental disorders. Neuroscientist　 2006,12:349-361.
  7. Kato T*, Iwamoto K, Kakiuchi C, Kuratomi G, Okazaki Y. Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders. Mol Psychiatry　2005,10:622-630.
このページのTOPへ

日本語総説など

  1. 荒木剛、岩本和也、笠井清登　統合失調症と脳―発達か変性か？ 脳バンク―精神疾患の謎を解くために　加藤忠史&ブレインバンク委員会編、光文社　2011,5:p194-200
  2. 岩本和也、文東美紀　DNAメチル化研究の最新の動向、分子精神医学　2011,11:90-93
  3. 加藤忠史、文東美紀、岩本和也　神経細胞のDNAメチル化、分子精神医学　2011,11:112-117
  4. 文東美紀、岩本和也、加藤忠史　セロトニン2C受容体、生体の科学　2010,61:394-396
  5. 文東美紀、岩本和也　気分障害患者の死後脳におけるオミックス研究、Medical Bio　2010,48:46-51
  6. 岩本和也、加藤忠史　脳神経系ゲノムの多型性と精神疾患、脳と精神の医学　2009,20:331-337.
  7. 岩本和也、加藤忠史　双極性障害のゲノムワイド研究、医学のあゆみ　2009;231:1019-1022.
  8. 岩本和也、加藤忠史　ゲノム多型の遺伝子発現への影響評価と精神疾患研究、医学のあゆみ 2009,229:199-201.
  9. 加藤忠史、岩本和也　精神疾患とepigenetics、細胞工学　2009,28:567-571.
  10. 文東美紀、岩本和也、加藤忠史　精神疾患におけるPyrosequencingの利用、エピジェネティクス関連Protocol 羊土社　2008
  11. 岩本和也、加藤忠史　セロトニン2C受容体のRNA編集と精神疾患、薬学雑誌　 2008,128:521-525.
  12. 岩本和也　オリゴデンドロサイト関連遺伝子、KEY WORD精神第4版　先端医学社　2007,152-153.
  13. 岩本和也、加藤忠史　ヒト死後脳を用いた遺伝子発現解析における交絡因子の影響解析と実際的な研究ストラテジーの検討、精神薬療研究年報　2007,39:177-184.
  14. 岩本和也　精神疾患に対するepigenetics的アプローチの可能性、Psychiatry Today　 2007,13:19-20.
  15. 岩本和也、加藤忠史　気分障害患者死後脳を用いたDNAマイクロアレイ研究、分子精神医学　2006,17:257-263.
  16. 加藤忠史、岩本和也　エピジェネティクス、分子精神医学　2006,6:72-74.