科学技術振興機構 さきがけ エピジェネティクスの制御と生命機能 エピジェネティクスの制御と生命機能さきがけ独立行政法人科学技術振興機構

研究成果

金田 るり(Ruri KANEDA)

(corresponding author に*印をしています。)

原著欧文論文

 

  1. akahiko Nishiyama; Ruri Kaneda; Tomohiko Ono; Shugo Tohyama; Hisayuki Hashimoto; Jin Endo; Hikaru Tsuruta; Shinsuke Yuasa; Masaki Ieda; Shinji Makino; Keiichi Fukuda,miR-142-3p is essential for hematopoiesis and affects cardiac cell fate in zebrafish,Biochemical and Biophysical Research Communications, Volume 338, Issue 2, 16 December 2005, Pages 1256-1262
  2. Hara M, Yuasa S, Shimoji K, Onizuka T, Hayashiji N, Ohno Y, Arai T, Hattori F, Kaneda R, Kimura K, Makino S, Sano M, Fukuda K. G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation. J Exp Med. 2011;208(4):715-727.
  3. Tamura Y, Matsumura K, Sano M, Tabata H, Kimura K, Ieda M, Arai T, Ohno Y, Kanazawa H, Yuasa S, Kaneda R, Makino S, Nakajima K, Okano H, Fukuda K. Nueral crest-derived stem cells migrate and differentiate into cardiomyocytes after myocardial infarction. Arterioscler Thromb Vasc Biol. 2011;31(3):582-589.
  4. Zhang Y, Sano M, Shinmura K, Tamaki K, Katsumata Y, Matsuhashi T, Morizane S, Ito H, Hishiki T, Endo J, Zhou H, Yuasa S, Kaneda R, Suematsu M, Fukuda K. 4-hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nfr2-dependent pathway. J Mol Cell Cardiol. 2010;49(4):576-586.
  5. Yuasa S, Onizuka T, Shimoji K, Ohno Y, Kageyama T, Yoon SH, Egashira T, Seki T, Hashimoto H, Nishiyama T, Kaneda R, Murata M, Hattori F, Makino S, Sano M, Ogawa S, Harvey RP, Fukuda K. Zac1 is an essential transcription factor for cardiac morphogenesis. Circ Res. 2010;106(6):1083-1091.
  6. Hattori F, Chen H, Yamashita H, Tohyama S, Satoh YS, Yuasa S, Li W, Yamakawa H, Tanaka T, Onitsuka T, Shimoji K, Ohno Y, Egashira T, Kaneda R, Murata M, Hidaka K, Morisaki T, Sasaki E, Suzuki T, Sano M, Makino S, Oikawa S, Fukuda K. Nongenetic method for purifying stem cell-derived cardiomyocytes.  Nat Methods. 2010;7(1):61-6.
  7. Wada T, Yamashita Y, Saga Y, Takahashi K, Koinuma K, Choi YL, Kaneda R, Fujiwara S, Soda M, Watanabe H, Kurashina K, Hatanaka H, Enomoto M, Takada S, Mano H, Suzuki M. Screening for genetic abnormalities involved in ovarian carcinogenesis using retroviral expression libraries.  Int J Oncol. 2009;35(5):973-6.
  8. Kaneda R, Fukuda K. MicroRNA is a new diagnostic and therapeutic target for cardiovascular disease and regenerative medicine.  Circ J. 2009;73(8):1397-8.
  9. Tokudome S, Sano M, Shinmura K, Matsuhashi T, Morizane S, Moriyama H, Tamaki K, Hayashida K, Nakanishi H, Yoshikawa N, Shimizu N, Endo J, Katayama T, Murata M, Yuasa S, Kaneda R, Tomita K, Eguchi N, Urade Y, Asano K, Utsunomiya Y, Suzuki T, Taguchi R, Tanaka H, Fukuda K. Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis.  J Clin Invest. 2009;119(6):1477-88.
  10. Kaneda R, Takada S, Yamashita Y, Choi YL, Nonaka-Sarukawa M, Soda M, Misawa Y, Isomura T, Shimada K, Mano H. Genome-wide histone methylation profile for heart failure.  Genes Cells. 2009;14(1):69-77.
  11. Choi YL, Tsukasaki K, O'Neill MC, Yamada Y, Onimaru Y, Matsumoto K, Ohashi J, Yamashita Y, Tsutsumi S, Kaneda R, Takada S, Aburatani H, Kamihira S, Nakamura T, Tomonaga M, Mano H. A genomic analysis of adult T-cell leukemia.  Oncogene.. 2007;26(8):1245-55.
  12. Yamashita Y, Ohashi J, Hirai Y, Choi YL, Kaneda R, Fujiwara S, Arai Y, Akutsu M, Tsutsumi C, Miyazaki Y, Usuki K, Teramura M, Mitani K, Kano Y, O'neill MC, Urabe A, Tomonaga M, Ozawa K, Mano H. Gene expression profiles of CD133-positive fractions predict the survival of individuals with acute myeloid leukemia. Cancer Genomics & Proteomics. 2006:3:169-182.
  13. Takada S, Wada T, Kaneda R, Choi YL, Yamashita Y, Mano H. Evidence for activation of Amh gene expression by steroidogenic factor 1.  Mech Dev. 2006;123(6):472-80.
  14. Choi YL, Kaneda R, Wada T, Fujiwara S, Soda M, Watanabe H, Kurashina K, Hatanaka H, Enomoto M, Takada S, Yamashita Y, Mano H. Identification of a constitutively active mutant of JAK3 by retroviral expression screening.  Leuk Res. 2006;31(2):203-9.
  15. Ishikawa J, Kario K, Matsui Y, Shibasaki S, Morinari M, Kaneda R, Hoshide S, Eguchi K, Hojo Y, Shimada K. Collagen metabolism in extracellular matrix may be involved in arterial stiffness in older hypertensive patients with left ventricular hypertrophy.  Hypertens Res. 2005;28(12):995-1001.
  16. Kaneda R, Kario K, Hoshide S, Umeda Y, Hoshide Y, Shimada K. Morning blood pressure hyper-reactivity is an independent predictor for hypertensive cardiac hypertrophy in a community-dwelling population.  Am J Hypertens.. 2005;18:1528-33.
  17. Fujiwara S, Yamashita Y, Choi YL, Wada T, Kaneda R, Takada S, Maruyama Y, Ozawa K, Mano H. Transforming activity of the lymphotoxin-beta receptor revealed by expression screening.Biochem Biophys Res Commun. 2005;338(2):1256-62.
  18. Koinuma K, Yamashita Y, Liu W, Hatanaka H, Kurashina K, Wada T, Takada S, Kaneda R, Choi YL, Fujiwara SI, Miyakura Y, Nagai H, Mano H. Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability.  Oncogene.. 2005;25(1):139-46.
  19. Takada S, Ota J, Kansaku N, Yamashita H, Izumi T, Ishikawa M, Wada T, Kaneda R, Choi YL, Koinuma K, Fujiwara S, Aoki H, Kisanuki H, Yamashita Y, Mano H. Nucleotide sequence and embryonic expression of quail and duck Sox9 genes. Gen Comp Endocrinol. 2005;145(2):208-13.
  20. Kaneda R, Kario K. Loss of diurnal rhythms of blood pressure and heart rate due to high fat feeding.  Am J Hypertens.. 2005;18(10):1327-8.
  21. Kisanuki H, Choi YL, Wada T, Moriuchi R, Fujiwara S, Kaneda R, Koinuma K, Ishikawa M, Takada S, Yamashita Y, Mano H. Retroviral expression screening of oncogenes in pancreatic ductal carcinoma. Eur J Cancer. 2005;41(14):2170-5.
  22. Ishikawa J, Kario K, Hoshide S, Eguchi K, Morinari M, Kaneda R, Umeda Y, Ishikawa S, Kuroda T, Hojo Y, Shimada K; J-MORE Study Group. Determinants of exaggerated difference in morning and evening blood pressure measured by self-measured blood pressure monitoring in medicated hypertensive patients: Jichi Morning Hypertension Research (J-MORE) Study. Am J Hypertens. 2005;18(7):958-65.
  23. Ishikawa M, Yoshida K, Yamashita Y, Ota J, Takada S, Kisanuki H, Koinuma K, Choi YL, Kaneda R, Iwao T, Tamada K, Sugano K, Mano H. Experimental trial for diagnosis of pancreatic ductal carcinoma based on gene expression profiles of pancreatic ductal cells. Cancer Sci. 2005;96(7):387-93.
  24. Koinuma K, Kaneda R, Toyota M, Yamashita Y, Takada S, Choi YL, Wada T, Okada M, Konishi F, Nagai H, Mano H. Screening for genomic fragments that are methylated specifically in colorectal carcinoma with a methylated MLH1 promoter. Carcinogenesis. 2005;26(12):2078-85.
  25. Kaneda R, Ueno S, Yamashita Y, Choi YL, Koinuma K, Takada S, Wada T, Shimada K, Mano H. Genome-wide screening for target regions of histone deacetylases in cardiomyocytes.  Circ Res. 2005;97(3):210-8.
  26. Choi YL, Moriuchi R, Osawa M, Iwama A, Makishima H, Wada T, Kisanuki H, Kaneda R, Ota J, Koinuma K, Ishikawa M, Takada S, Yamashita Y, Oshimi K, Mano H. Retroviral expression screening of oncogenes in natural killer cell leukemia.  Leuk Res. 2005;29(8):943-9.
  27. Kaneda R, Toyota M, Yamashita Y, Koinuma K, Choi YL, Ota J, Kisanuki H, Ishikawa M, Takada S, Shimada K, Mano H. High-throughput screening of genome fragments bound to differentially acetylated histones. Genes Cells. 2004;9:1167-74.
  28. Tsutsumi C, Ueda M, Miyazaki Y, Yamashita Y, Choi YL, Ota J, Kaneda R, Koinuma K, Fujiwara S, Kisanuki H, Ishikawa M, Ozawa K, Tomonaga M, Mano H. DNA microarray analysis of dysplastic morphology associated with acute myeloid leukemia. Exp Hematol. 2004;32:828-35.
このページのTOPへ

総説

  1. 金田るり、福田恵一:心不全は遺伝しますか? 心不全日常診療Q&A (南山堂) 46-47, 2011.
  2. 金田るり、島田和幸: 本態性高血圧. 循環器疾患 最新の治療 2006-2007 (南江堂)371-375.
  3. 金田るり、苅尾七臣、島田和幸: 高血圧治療ガイドラインにみる降圧薬選択の差異. Annual Review 循環器 2005 (中外医学社)264-273, 2005.
  4. 金田るり、苅尾七臣: 高血圧治療ガイドライン2004のポイントと生活習慣修正の位置付け. 臨床栄養 107:155-159, 2005.
このページのTOPへ

発表&講演

  1. Tomohiko Ono, Ruri Kaneda, Takahiko Nishiyama, Tomohiro Matsuhashi, Takahide Arai, Masaki Ieda, Motoaki Sano, Keiichi Fukuda  「Histone H3 lysine-9 methyltransferase inhibitor ameliorates left ventricular dysfunction in animal model」 第75回日本循環器学会総会、2011年8月 横浜
  2. 金田るり 「慢性心不全のエピジェネティック解析」第27回日光カンファレンス 2011年7月 宇都宮
  3. Tomohiko Ono, Ruri Kaneda, Takahiko Nishiyama, Tomohiro Matsuhashi, Takahide Arai, Motoaki Sano, Keiichi Fukuda 「Epigenetic therapy for heart failure」Keystone Symposia, Molecular Cardiology: Disease Mechanisms and Experimental Therapeutics, 2011年2月 Keystone Resort, Colorado, USA
  4. 金田るり、小野智彦、西山崇比古、間野博行、福田恵一 「H3K9メチル基転移酵素阻害薬による心不全改善効果の検討」 第33回 日本分子生物学会、2010年12月 神戸
  5. 金田るり「慢性心不全のエピジェネティック解析」 第1回Molecular Cardiovascular Conference II, 2010年9月 北海道