科学技術振興機構 さきがけ エピジェネティクスの制御と生命機能 エピジェネティクスの制御と生命機能さきがけ独立行政法人科学技術振興機構

研究成果

平谷　伊智朗（Ichiro Hiratani)

 

原著欧文論文

  1. Ryba T,Hiratani I, Lu J, Itoh M, Kulik M, Zhang J, Dalton S, Gilbert DM (2010) Evolutionarily conserved replication timing profiles predict long-range chromatin interactions and distinguish closely related cell types. Genome Research 20:761-770.
  2. Hiratani I, Ryba T, Itoh M, Rathjen J, Kulik M, Papp B, Fussner E, Bazett-Jones DP, Plath K, Dalton S, Rathjen PD, Gilbert DM (2010) Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis. Genome Research 20:155-169.
  3. Yokochi T, Poduch K, Ryba T, Lu J, Hiratani I, Tachibana M, Shinkai Y, Gilbert DM (2009) G9a selectively represses a class of late-replicating genes at the nuclear periphery. Proc Natl Acad Sci USA 106:19363-19368.
  4. Weddington N*, Stuy A*, Hiratani I*, Ryba T, Yokochi T, Gilbert DM (2008) ReplicationDomain: a visualization tool and comparative database for genome-wide replication timing data. BMC Bioinformatics 9:530. (*Equal Contributions)
  5. Hiratani I, Ryba T, Itoh M, Yokochi T, Schwaiger M, Chang CW, Lyou Y, Townes TM, Schubeler D, Gilbert DM (2008) Global reorganization of replication domains during embryonic stem cell differentiation. PLoS Biology 6:e245.
  6. Hiratani I, Leskovar A, Gilbert DM (2004) Differentiation-induced replication-timing changes are restricted to AT-rich/long interspersed nuclear element (LINE)-rich isochores. Proc Natl Acad Sci USA 101:16861-16866.
  7. Hiratani I, Yamamoto N, Mochizuki T, Ohmori S, Taira M (2003) Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions. Development 130:4161-4175.
  8. Hikasa H, Shibata M, Hiratani I, Taira M. (2002) The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling. Development 129:5227-5239.
  9. Hiratani I, Mochizuki T, Tochimoto N, Taira M (2001) Functional domains of the LIM homeodomain protein Xlim-1 involved in negative regulation, transactivation, and axis formation in Xenopus embryos. Developmental Biology 229:456-467.
  10. Tsuji T, Sato A, Hiratani I, Taira M, Saigo K, Kojima T (2000) Requirements ofLim1, a Drosophila LIM-homeobox gene, for normal leg and antennal development. Development 127:4315-4323.
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欧文総説

  1. Ryba T, Battaglia D, Pope BD, Hiratani I, Gilbert DM (2011) Genome-scale analysis of replication timing: from bench to bioinformatics. Nature Protocols 6:870-895.
  2. Gilbert DM, Takebayashi SI, Ryba T, Lu J, Pope BD, Wilson KA, Hiratani I (2010) Space and time in the nucleus: developmental control of replication timing and chromosome architecture. Cold Spring Harbor Symposia on Quantitative Biology 75:143-153.
  3. Hiratani I, Gilbert DM (2010) Autosomal lyonization of replication domains during early mammalian development. In: The Cell Biology of Stem Cells. Landes Bioscience and Springer (edited by Eran Meshorer and Kathrin Plath). Advances in Experimental Medicine and Biology 695:41-58.
  4. Pope BD, Hiratani I, Gilbert DM (2010) Domain-wide regulation of DNA replication timing during mammalian development. Chromosome Research 18:127-136.
  5. Hiratani I, Takebayashi S, Lu J, Gilbert DM (2009) Replication timing and transcriptional control: beyond cause and effect. Part II. Curr Opin Genet Dev 19:142-149.
  6. Hiratani I, Gilbert DM (2009) Replication timing as an epigenetic mark. Epigenetics 4:93-97.
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和文総説

  1. 平谷伊智朗 (2008) DNA複製タイミングの発生過程における制御　細胞工学 27:1013-1019.
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国際学会（口頭発表のみ）

  1. Genome-wide dynamics of DNA replication timing revealed by in vitro models of mouse embryogenesis - implications for higher-order genome organization and its developmental regulation. The 9th Annual CDB Symposium "Epigenetic Landscape in Development and Disease" (RIKEN CDB, Kobe, Japan) March 2011
  2. Epiblast stage marks a period of global genome reorganization manifest by replication domain consolidation. EMBO Conference on Nuclear Structure and Dynamics (Avignon, France) October 2009
  3. Global re-organization of replication domains during embryonic stem cell differentiation. Cold Spring Harbor Laboratory Meeting "Dynamic Organization of Nuclear Function" (New York, USA) September 2008
  4. Regulation of replication timing during differentiation of mouse embryonic stem cells. EMBO Conference on Nuclear Structure and Dynamics (Montpellier, France) September 2007
  5. Dynamic epigenetic regulation during neural differentiation of mouse embryonic stem cells: replication timing changes and transcriptional regulation. Cold Spring Harbor Laboratory Meeting "Dynamic Organization of Nuclear Function" (New York, USA) September 2006
  6. Replication timing changes and transcriptional regulation during neural differentiation of mouse embryonic stem cells. Cold Spring Harbor Laboratory Meeting "Eukaryotic DNA Replication" (New York, USA) September 2005