科学技術振興機構 さきがけ エピジェネティクスの制御と生命機能 エピジェネティクスの制御と生命機能さきがけ独立行政法人科学技術振興機構

研究成果

田上 英明(Hideaki Tagami)

(corresponding author に*印をしています。)

原著欧文論文

  1. Alejandra Loyola, Hideaki Tagami, Tiziana Bonaldi, Daniele Roche, Jean-Pierre Quivy, Axel Imhof, Yoshihiro Nakatani, Sharon Y R Dent and Genevieve Almouzni. The HP1α-CAF-1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin.
    EMBO Rep., 10, 769-775 (2009)
  2. Elaine M. Dunleavy, Daniele Roche, Hideaki Tagami, Nicolas Lacoste, Dominique Ray-Gallet, Yusuke Nakamura, Yataro Daigo, Yoshihiro Nakatani and Genevieve Almouzni-Pettinotti. HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres.
    Cell, 137, 487-497 (2009)
  3. Shiori Kohno, Takao Kohno, Yoshimi Nakano, Kenta Suzuki, Moe Ishii, Hideaki Tagami, Atsushi Baba and Mitsuharu Hattori. Mechanism and significance of specific proteolytic cleavage of Reelin.
    Biochem. Bioph. Res. Co., 380, 93-97 (2009)
  4. Midori Shimada, Hiroyuki Niida, Doaa H. Zineldeen, Hideaki Tagami, Masafumi Tanaka, Hiroyuki Saito, and Makoto Nakanishi. Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression.
    Cell, 132, 221-32(2008)
  5. Shinji Terakura, Yoshihisa Ueno, Hideaki Tagami, Saeko Kitakura, Chiyoko Machida, Hiroetsu Wabiko, Hiroji Aiba, Leon Otten, Hironaka Tsukagoshi, Kenzo Nakamura, and Yasunori Machida An oncoprotein from the plant pathogen Agrobacterium has histone-chaperone-like activity.
    Plant Cell, 19, 2855-65(2007)
  6. Xia Li, Reiko Hirano, Hideaki Tagami, and Hiroji Aiba. Protein tagging at rare codons is caused by tmRNA action at the 3' end of nonstop mRNA generated in response to ribosome stalling.
    RNA, 12, 248-255 (2006)
  7. Yuya Ogawa, Tatsuya Ono, Yuka Wakata, Katsuya Okawa, Hideaki Tagami, and Keiichi Shibahara. The histone variant macroH2A1.2 is mono-ubiquitinated at its histone domain.
    Biochem. Bioph. Res. Co., 14, 204-209 (2005)
  8. Soumya Awasthi, Anima Sharma, Kasuen Wong, Junyu Zhang, Elizabeth F. Matlock, Lowery Rogers, Pamela Motloch, Shigeki Takemoto, Hirokuni Taguchi, Michael D. Cole, Bernhard Luscher, Oliver Dittrich, Hideaki Tagami, Yoshihiro Nakatani, Monnie McGee, Anne-Marie Girard, Luke Gaughan, Craig N. Robson, Raymond J. Monnat, Jr., and Robert Harrod. A Human T-Cell Lymphotropic Virus Type 1 Enhancer of Myc Transforming Potential Stabilizes Myc-TIP60 Transcriptional Interactions
    Molecular and Cellular Biology, 25, 6178-6198 (2005)
  9. Jean-Pierre Quivy, Daniele Roche, Doris Kirschner, Hideaki Tagami, Yoshihiro Nakatani and Genevieve Almouzni. A CAF-1 dependent pool of HP1 during heterochromatin duplication.
    EMBO J. 17, 3516-26 (2004)
  10. Hideaki Tagami, Dominique Ray-Gallet, Genevieve Almouzni, and Yoshihiro Nakatani Histone H3.1 and H3.3 Complexes Mediate Nucleosome Assembly Pathways Dependent or Independent of DNA Synthesis.
    Cell, 116, 51-61 (2004)
  11. Timur M. Yusufzai, Hideaki Tagami, Yoshihiro Nakatani, and Gary Felsenfeld. CTCF Tethers an Insulator to Subnuclear Sites, Suggesting Share Insulator Mechanisms Across Species.
    Molecular Cell, 13, 291-298 (2004)
  12. Takafumi Sunohara, Kaoru Jojima, Hideaki Tagami, Toshifumi Inada, and Hiroji Aiba. Ribosome Stalling during Translation Elongation Induces Cleavage of mRNA Being Translated in Escherichia coli.
    Journal of Biological Chemistry, 279, 15368-15375 (2004)
  13. Waleed El-Kazzaz, Teppei Morita, Hideaki Tagami, Toshifumi Inada and Hiroji Aiba. Metabolic block at early stages of glycolytic pathway leads to the activation RcsC/B system via perturbation in dTDP-glucose synthesis in Escherichia coli.
    Molecular Microbiology, 51, 1117-1128 (2004)
  14. Steven R. Grossman, Maria E. Deato, Brignone Chrystelle, Ho Man Chan, Andrew Kung,
    Hideaki Tagami, Yoshihiro Nakatani, and David M. Livingston. Polyubiquitination of p53 by a ubiquitin ligase activity of p300.
    Science, 300, 342-344 (2003)
  15. Vanessa Bres, Hideaki Tagami, Jean-Marie Peloponese, Erwan Loret, Kuan-Teh Jeang, Yoshihiro Nakatani, Stephane Emiliani, Monsef Benkirane, and Rosemary E Kiernan. Differential acetylation of Tat coordinates its interaction with the co-activators cyclin T1 and PCAF.
    EMBO J., 16, 6811-6819 (2002)
  16. Hideaki Tagami and Hiroji Aiba. An inactive open complex mediated by an UP element at Escherichia coli promoters.
    Proc. Natl. Acad. Sci. USA, 96, 7202-7207. (1999)
  17. Yuya Tanaka , Keiko Kimata K, Toshifumi Inada , Hideaki Tagami ,and Hiroji Aiba. Negative regulation of the pts operon by Mlc: mechanism underlying glucose induction in Escherichia coli.
    Genes Cells, 4, 391-9. (1999)
  18. Hideaki Tagami and Hiroji Aiba. A common role of CRP in transcription activation: CRP acts transiently to stimulate events leading to open complex formation at a diverse set of promoters.
    EMBO J., 17, 1759-1767. (1998)
  19. Keiko Kimata, Toshifumi Inada, Hideaki Tagami and Hiroji Aiba. A global repressor (Mlc) is involved in glucose induction of the ptsG gene encoding major glucose transporter in Escherichia coli.
    Molecular Microbiology, 29, 1509-1519. (1998)
  20. Hideaki Tagami and Hiroji Aiba. Role of CRP in transcription activation at Escherichia coli lac promoter: CRP is dispensable after the formation of open complex.
    Nucleic Acids Research, 23, 599-605. (1995)
  21. Hideaki Tagami, Toshifumi Inada, Tadashi Kunimura and Hiroji Aiba. Glucose lowers CRP* levels resulting in repression of the lac operon in cells lacking cAMP.
    Molecular Microbiology, 17, 251-258. (1995) 
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総説/欧文

  1. Hideaki Tagami From the view of histone complexes: A sketch of molecular players on the chromatin assembly events.
    In "DNA Structure, Chromatin and Gene Expression" Transworld Research Network, 57, 145-158 (2006)
  2. Yoshihiro Nakatani, Hideaki Tagami and Elena Shestakova How is epigenetic information on chromatin inherited after DNA replication
    In "The histone code and beyond" Ernst Schering Res Found Workshop, 57, 89-96 (2006)
  3. Y. NAKATANI, D. RAY-GALLET, J.-P. QUIVY, H. TAGAMI, AND G. ALMOUZNI. Two Distinct Nucleosome Assembly Pathways: Dependent or Independent of DNA Synthesis Promoted by Histone H3.1 and H3.3 Complexes
    In "Epigenetics" Symposia on Quantitative Biology, Volume LXIX. Cold Spring Harbor Laboratory Press (2004)
  4. G. FELSENFELD, B. BURGESS-BEUSSE, C. FARRELL, M. GASZNER, R. GHIRLANDO, S. HUANG, C. JIN, M. LITT, F. MAGDINIER, V. MUTSKOV, Y. NAKATANI, H. TAGAMI, A. WEST, AND T. YUSUFZAI Chromatin Boundaries and Chromatin Domains
    In "Epigenetics" Symposia on Quantitative Biology, Volume LXIX. Cold Spring Harbor Laboratory Press (2004)
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総説/日本語

  1. 田上英明、饗場弘二 「DNaseI フットプリンティング法」 『改訂第5版 新遺伝子工学ハンドブック』 実験医学別冊 村松正實、山本雅、岡崎康司/編  pp181-184 羊土社 (2010)
  2. 田上英明 「S1マッピングによるRNA末端の決定」 『RNA実験ノート』上 無敵のバイオテクニカルシリーズ 稲田利文、塩見春彦/編 pp107-113 羊土社(2008)
  3. 田上英明 「酵母からのヒストン複合体精製法」 『タンパク質実験マニュアル』 胡桃坂仁志/編 pp51-58 朝倉書店(2006)
  4. 田上英明 「ヒストン複合体から見えてくるクロマチン形成機構:クロマチン構造とエピジェネティクス制御」  特集:クロマチンコレオグラフィー 生化学 第77巻 第3号 pp.213-221  日本生化学会(2005)
  5. 田上英明、中谷喜洋 「クロマチン構造と修飾」 『転写がわかる』 わかる実験医学シリーズ 半田宏/編 pp40-48 羊土社 (2002)
  6. 田上英明 「ヒストンのアセチル化とクロマチン制御」 『ゲノム機能を担う核:染色体のダイナミクス』花岡文雄、永田恭介/編 実験医学増刊号 20(11):pp70-76 羊土社 (2002)
  7. 田上英明、饗場 弘二 「sigma 因子」「CRP」 『転写因子』第2版 実験医学別冊 Bio Science 新用語ライブラリー  田村隆明・山本雅之・安田國雄/編 pp58-61 羊土社 (1999)
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発表/英語

  1. Hideaki Tagami and Maki Kato "A new mode of histone dynamics: HiTAP1 separates histone H3 and H4", Cold Spring Harbor meeting on Mechanisms of Eukaryotic Transcription, NY, 8/30-9/3 2011 (poster)
  2. Hideaki Tagami, Miki Inui, Izumi Hosaka "A new mode of histone dynamics: HiTAP1 dissociates histone H3 and H4", EMBO Conference Series Chromatin and Epigenetics, Heidelberg, 6/1-5 2011 (talk)
  3. Hideaki Tagami, Miki Inui, Izumi Hosaka "A New Mode of Histone Dynamics: HiTAP1 Dissociates Histone H3/H4", GENO Field 2011, Awaji 1/24-26 2011 (talk)
  4. Hideaki Tagami "Making Nucleosomes: Various recipes and the chefs in histone complexes", ISBDS2010, Nagoya 8/1-3 2010 (talk)
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発表/日本語

  1. 田上英明、加藤麻希 「新規ヒストン結合因子HiTAP1による動的エピジェネティクス制御機構」 第84回日本生化学会大会, 京都 9/21-24 2011 (シンポジウム口演)
  2. 田上英明「別れと出会い:新規ヒストンH3結合因子HiTAP1はH3/H4を解離させる」構造エピゲノム研究会 第3回ワークショップ、横浜 4/25 2011 (口演)
  3. 田上 英明、伊縫 美妃、保坂いづみ「新規ヒストンH3結合因子HiTAP1はH3/H4を解離させる」第28回染色体ワークショップ、加賀温泉 1/11-13 2011 (口演)
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翻訳

  1. 田上英明 「13章 ヒストンバリアントとエピジェネティクス」 『エピジェネティクス』堀越正美 監訳 pp291-309 培風館(2010)