科学技術振興機構 さきがけ エピジェネティクスの制御と生命機能 エピジェネティクスの制御と生命機能さきがけ独立行政法人科学技術振興機構

研究成果

磯野 協一 (Kyoichi Isono)

原著欧文論文

  1. Tanuma N, Kim SE, Beullens M, Tsubaki Y, Mitsuhashi S, Nomura M, Kawamura T, Isono K, Koseki H, Sato M, Bollen M, Kikuchi K, Shima H. (2008) Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 snRNP component, spliceosome-associated protein 155 (Sap155). J. Biol. Chem. 283, 35805-35814.
  2. Puschendorf M, Terranova R, Boutsma E, Mao X, Isono KI, Brykczynska U, Kolb C, Otte AP, Koseki H, Orkin SH, van Lohuizen M, Peters AH. (2008) PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat. Genet. 40, 411-420.
  3. Hiraoka S, Furuichi T, Nishimura G, Shibata S, Yanagishita M, Rimoin DL, Superti-Furga A, Nikkels PG, Ogawa M, Katsuyama K, Toyoda H, Kinoshita-Toyoda A, Ishida N, Isono K, Sanai Y, Cohn DH, Koseki H, Ikegawa S. (2007) Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human. Nat. Med. 13, 1363-1367.
  4. de la Cruz CC, Kirmizis A, Simon MD, Isono K, Koseki H, Panning B. (2007) The Polycomb Group Protein SUZ12 regulates histone H3 lysine 9 methylation and HP1alpha distribution. Chromosome Res. 15, 299-314.
  5. Takada Y, Isono K, Shinga J, Turner JM, Kitamura H, Ohara O, Watanabe G, Singh PB, Kamijo T, Jenuwein T, Burgoyne PS, Koseki H. (2007) Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes. Development 134, 579-590.
  6. Sato T, Endoh M, Yoshida H, Yasuo S, Katsuno T, Saito Y, Isono K, Koseki H. (2006) Mammalian Polycomb complexes are required for Peyer's patch development by regulating lymphoid cell proliferation. Gene 379, 166-174.
  7. Aikawa Y, Nguyen LA, Isono K, Takakura N, Tagata Y, Schmitz ML, Koseki H, Kitabayashi I. (2006) Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J. 25, 3955-3965.
  8. #Fujimura Y, #Isono K, Vidal M, Endoh M, Kajita H, Mizutani-Koseki Y, Takihara Y, van Lohuizen M, Otte A, Jenuwein T, Deschamps J, Koseki H. (2006) Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development 133, 2371-2381. (#equally contributed)
  9. Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, Yuan B, Bell GW, Herbolsheimer E, Hannett NM, Sun K, Odom DT, Otte AP, Volkert TL, Bartel DP, Melton DA, Gifford DK, Jaenisch R, Young RA. (2006) Control of developmental regulators by polycomb in human embryonic stem cells. Cell 125, 301-313.
  10. Isono K, Nemoto K, Li Y, Takada Y, Suzuki R, Katsuki M, Nakagawara A, Koseki H. (2006) Overlapping roles for homeodomain-interacting protein kinases Hipk1 and Hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol. Cell. Biol. 26, 2758-2771.
  11. Uchida H, Isono K, Tomizawa K, Iwano M, Yamashita H, Fukuzawa H, Ohyama K, Yokota A. (2005) Synthesis of Rubisco gene products is upregulated by increasing the copy number of rbcL gene in Chlamydomonas chloroplast genome, without increased accumulation of the two Rubisco subunits. Plant Biotechnol., 22, 145-149.
  12. Isono K, Fujimura Y, Shinga J, Yamaki M, O-Wang J, Takihara Y, Murahashi Y, Takada Y, Mizutani-Koseki Y, Koseki H. (2005) Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes. Mol. Cell. Biol. 25, 6694-6706.
  13. Baba T, Shimizu T, Suzuki Y, Ogawara M, Isono K, Koseki H, Kurosawa H, Shirasawa T. (2005) Estrogen, insulin, and dietary signals cooperatively regulate longevity signals to enhance resistance to oxidative stress in mice. J. Biol. Chem., 280, 16417-16426.
  14. Isono K, Mizutani-Koseki Y, Komori T, Schmidt-Zachmann MS, Koseki H. (2005) Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev., 19, 536-541.
  15. Kaneko T, Miyagishima H, Hasegawa T, Mizutani-Koseki Y, Isono K, Koseki H. (2003) The mouse YAF2 gene generates two distinct transcripts and is expressed in pre-and postimplantation embryos. Gene, 315, 183-192.
  16. Miyagishima H, Isono K, Fujimura Y, Iyo M, Takihara Y, Masumoto H, Vidal M, Koseki H. (2003) Dissociation of mammalian Polycomb-group proteins, Ring1B and Rae28/Ph1, from the chromatin correlates with configuration changes of the chromatin in mitotic and meiotic prophase. Histochem. Cell Biol., 120, 111-119.
  17. Horie A, Isono K, Koseki H. (2003) Generation of a monoclonal antibody against the mouse Sf3b1 (SAP155) gene product for U2 snRNP component of spliceosome. Hybrid. Hybridomics, 22, 117-119.
  18. Ikegami T, Suzuki Y, Shimizu T, Isono K, Koseki H, Shirasawa T. (2002) Model mice for tissue-specific deletion of the manganese superoxide dismutase (MnSOD) gene. Biochem. Biophys. Res. Commun., 296, 729-736.
  19. Suzuki M, Mizutani-Koseki Y, Fujimura YI, Miyagishima H, Kaneko T, Takada Y, Akasaka T, Tanzawa H, Takihara Y, Nakano M, Masumoto H, Vidal M, Isono K, Koseki H. (2002) Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development, 129, 4171-4183.
  20. Yamaki M, Isono K, Takada Y, Abe K, Akasaka T, Tanzawa H, Koseki H. (2002) The mouse Edr2 (Mph2) gene has two forms of mRNA encoding 90- and 36-kDa polypeptides. Gene, 288, 103-110.
  21. K. Yoshimoto, M. Sakaiya, K. Isono, and H. Kobayashi. (2001) Comparison of strength of endogenous and exogenous gene promoters in Arabidopsis chloroplasts. Plant Biotech., 18, 135-142.
  22. Nakai D, Yuasa S, Takahashi M, Shimizu T, Asaumi S, Isono K, Takao T, Suzuki Y, Kuroyanagi H, Hirokawa K, Koseki H, Shirsawa T. (2001) Mouse homologue of coq7/clk-1, longevity gene in Caenorhabditis elegans, is essential for coenzyme Q synthesis, maintenance of mitochondrial integrity, and neurogenesis. Biochem. Biophys. Res. Commun., 289, 463-471.
  23. K. Isono, K. Abe, Y. Tomaru, Y. Okazaki, Y. Hayashizaki, and H. Koseki (2001) Molecular cloning, genetic mapping, and expression of the mouse Sf3b1 (SAP155) gene for U2 snRNP component of spliceosome. Mam. Genome, 12, 192-198.
  24. K. Isono, K. Satoh, and H. Kobayashi (2000) Molecular cloning of a cDNA encoding a novel Ca(2+)-dependent nuclease of Arabidopsis that is similar to staphylococcal nuclease. Biochim. Biophys. Acta., 1491, 267-272.
  25. K. Isono, H. Yamamoto, K. Satoh, and H. Kobayashi (1999) An Arabidopsis cDNA encoding a DNA-binding protein that is highly similar to the DEAH family of RNA/DNA halicase genes. Nucleic Acids Res., 27, 3728-3735.
  26. K. Isono, M. Shimizu, K. Yoshimoto, Y. Niwa, K. Satoh, A. Yokota, and H. Kobayashi (1997) Leaf-specifically expressed genes for polypeptides destined for chloroplasts with dominants of・70 factors of bacterial RNA polymerases in Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA., 94, 14948-14953.
  27. K. Isono, Y. Niwa, K. Satoh, and H. Kobayashi (1997) Evidence for transcriptional regulation of plastid genes in Arabidopsis thaliana roots. Plant Physiol., 114, 623-630.
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日本語総説

  1. 磯野協一 (2004) ポリコーム群およびトリソラックス群タンパク質とヒストン修飾.細胞工学,
    23,1150-1154.
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国際学会での口頭発表

  1. he 2010 Cold Spring Harbor Asia Conference, Epigenetics, chromatin & transcription, Suzhou, May 2010
  2. 5th EMBL Mouse Molecular Genetics Meeting, Heidelberg, Sept 2003
  3. 4th EMBL Mouse Molecular Genetics Meeting, Heidelberg, Sept 2001
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講演

  1. 大阪大学蛋白質研究所セミナー
    「ポリコーム超分子複合体を介した細胞記憶の制御メカニズム」
    2006年10月(大阪)