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Elucidate the Parkinson's disease pathogenesis from a viewpoint of mitochondrial homeostatic control

Noriyuki Matsuda (photo)

Noriyuki Matsuda

Research Site Tokyo Metropolitan Institute of Medical Science
Department of Advanced Science for Biomolecules
Associate Director Researcher


Degradation of low-quality mitochondria carried out by PINK1 and Parkin plays an essential role in the maintenance of mitochondrial homeostasis. It is now believed that the collapse of this mechanism leads to the hereditary recessive Parkinson's disease. In this study, I elucidate the long-lasting mystery in this field, i.e. the molecular mechanism how Parkin is transferred to the low-quality mitochondria during homeostatic control.


  1. Okatsu K, Koyano F, Kimura M, Kosako H, Saeki Y, Tanaka K, Matsuda N.
    Phosphorylated ubiquitin chain is the genuine Parkin receptor.
    J Cell Biol. 2015 209(1):111-28. doi: 10.1083/jcb.201410050.
  2. Okatsu K, Kimura M, Oka T, Tanaka K, Matsuda N.
    Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment. J Cell Sci. 2015 128(5):964-78. doi: 10.1242/jcs.161000.
  3. Yamano K, Queliconi BB, Koyano F, Saeki Y, Hirokawa T, Tanaka K, Matsuda N.
    Site-specific Interaction Mapping of Phosphorylated Ubiquitin to Uncover Parkin Activation. J Biol Chem. 2015 290(42):25199-211. doi: 10.1074/jbc.M115.671446.
  4. Matsuda N, Kimura M, Queliconi BB, Kojima W, Mishima M, Takagi K, Koyano F, Yamano K, Mizushima T, Ito Y, Tanaka K.Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro. Sci Rep. 2017 7(1):12816. doi: 10.1038/s41598-017-13146-0.
  5. Matsuda N, Tanaka K.Cell biology: Tagged tags engage disposal.
    Nature. 2015 524(7565):294-5. doi: 10.1038/nature15199.