|Research Site||Kyoto Sangyo University|
|Faculty of Life Sciences|
The homeostasis in gut is maintained by the balance of proliferation and death of epithelial cells with the barrier function of epithelia. The impairment of them causes various disease such as cancer, inflammatory disease, and infection in gut. I focus on two related phenomena, cell death and DNA degradation, to decipher their molecular mechanism and role for gut homeostasis. The insight obtained from the project will contribute to understand the disease in gut and develop novel treatments against them.