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Maintenance of homeostasis through epigenetic regulation: an approach from genomic imprinting

Shinpei Yamaguchi (photo)

Shinpei Yamaguchi

Research Site Osaka University
Graduate school of Frontier Biosciences
Assistant Professor


Genomic imprinting is an epigenetic regulatory mechanism only observed in mammals. Imprinted genes are expressed differently in a parent-of-origin-specific manner. In this research project, we tackle the question how genomic imprinting is maintained in our body. Through genome-wide screening and functional assay of novel imprinting maintenance factors, we will try to reveal the physiological significance of genomic imprinting in homeostasis. Ultimately, we are aiming to apply our findings to prevent or treat human diseases.


  1. Riyo Konishi, Toru Nakano, Shinpei Yamaguchi. Distinct requirements for the maintenance and establishment of mouse embryonic stem cells. Stem Cells. Under review.