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Elucidation of the multi-tissue homeostatic network of the feeding clock for temporal regulation of metabolism

Megumi Hatori (photo)

Megumi Hatori

Research Site Keio University
School of Medicine
Project Associate Professor


Humans and animals feel hunger at certain times of the day. This metabolic rhythm is observed even in the absence of the hypothalamic suprachiasmatic nucleus, the location of the master clock controlling circadian rhythms. Therefore circadian and feeding rhythms work independently but communicate with each other to maintain metabolic homeostasis. The goal of this project is to understand and learn how to control metabolic state by revealing how the metabolic network in and across multiple tissues changes with the time of day and time of feeding in rodent and primate model animals. The research aims to realize new principles on the timing of circadian and metabolic homeostasis in biological systems.


  1. Mure LS*, Hatori M* (*equal contribution) et al., Melanopsin-Encoded Response Properties of Intrinsically Photosensitive Retinal Ganglion Cells. Neuron 90(5):1016-1027 (2016)
  2. Bushong EA et al., X-ray microscopy as an approach to increasing accuracy and efficiency of serial block-face imaging for correlated light and electron microscopy of biological specimens. Microsc Microanal. 21(1):231-8 (2015)
  3. Torii et al., Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression. EBioMedicine 15:210-219 (2017)