|Research Site||Keio University|
|School of Medicine|
|Project Associate Professor|
Humans and animals feel hunger at certain times of the day. This metabolic rhythm is observed even in the absence of the hypothalamic suprachiasmatic nucleus, the location of the master clock controlling circadian rhythms. Therefore circadian and feeding rhythms work independently but communicate with each other to maintain metabolic homeostasis. The goal of this project is to understand and learn how to control metabolic state by revealing how the metabolic network in and across multiple tissues changes with the time of day and time of feeding in rodent and primate model animals. The research aims to realize new principles on the timing of circadian and metabolic homeostasis in biological systems.