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The molecular mechanisms of replacement and excessive fibrosis in cardiac remodeling

Norihiko Takeda (photo)

Norihiko Takeda

Research Site University of Tokyo
Graduate School of Medicine
Assistant Professor


Cardiac remodeling develops after left ventricular pressure/volume overload occurs. Cardiac fibrosis and diastric dysfunction are the hallmarks of cardiac remodeling. While a cardiac fibroblast plays essential roles in cardiac remodeling, the molecular mechanisms of its activation are still unclear. In this study, we aim to elucidate the patholocial processes underlying cardiac fibroblast activation, which will help to establish a novel therapeutic approach for cardiac remodeling.


  1. Krzywinska E, Kantari-Mimoun C, Kerdiles Y, Sobecki M, Isagawa T, Gotthardt D, Castells M, Haubold J, Millien C, Viel T, Tavitian B, Takeda N, Fandrey J, Vivier E, Sexl V and Stockmann C. Loss of HIF-1α in Natural Killer cells inhibits tumour growth by stimulating non-productive angiogenesis
    Nature Communications. 2017 Nov 17;8(1):1597.
  2. Goodwin J, Choi H, Hsieh MH, Nuegent ML, Ahn JM, Hayenga HN, Singh PK, Shackelford DB, Lee IK, Shulaev V, Dhar S, Takeda N, Kim JW. Targeting HIF-1α/PDK1 Axis by Dichloroacetate (DCA) Suppresses Bleomycin-induced Pulmonary Fibrosis
    American Journal of Respiratory Cell and Molecular Biology. 2017 (in press)
  3. Abe H, Semba H, Takeda N
    The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases.
    J Atheroscler Thromb. 2017 Sep 1;24(9):884-894.
  4. Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW. Distinct Metabolic Phenotypes within Non-small Cell 1 Lung Cancer Define Selective Vulnerability to Glycolytic Inhibition of Lung Squamous Cell Carcinoma. Nature Communications. 2017 May 26;8:15503.
  5. Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R and Komuro I. HIF-1α-PDK1 axis induced active glycolysis plays an essential role in macrophage migratory capacity.
    Nature Communications 7,Article number:11635, 2016