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Establishment of technology to evaluate the all time scales reaction in whole body

Masamichi Yamamoto (photo)

Masamichi Yamamoto

Research Site Kyoto University
Graduate School of Medicine
Specific Lecturer


Disease is analyzed as an abnormality of each organ until now, technology to be evaluated as an organ that is connected by a network was missing. In addition, a technique for evaluating the reactions that occur in the long term have been developed, but the technology to evaluate the reactions that occur in all time scales, including a short period of time was missing. By using to develop a system that can be measured the cellular quality of bioactivities in real-time, make the establishment of technology to evaluate the reactions in all time scales and the whole body in this study.


  1. Nimura, K., Yamamoto, M., Takeichi, M., Saga, K., Takaoka, K., Kawamura, N., Nitta, H., Nagano, H., Ishino, S., Tanaka, T., Shwartz, R.J., Aburatani, H., Kaneda, Y. Regulation of alternative polyadenylation by Nkx2-5 and Xrn2 during mouse heart development. ELife, 2016, 5: e16030
  2. Nakano, M., Imamura, H., Sasaoka, N., Yamamoto, M., Uemura, N., Shudo, T., Fuchigami, T., Takahashi, R. and Kakizuka, A. ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson’s Disease. EBioMedicine, 2017, 22: 225-241