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Dynamic monitoring of homeostasis disruption using hyperpolarized 13C MRI

Shingo Matsumoto (photo)

Shingo Matsumoto

Research Site Hokkaido University
Graduate School of Information Science and Technology
Associate Professor


Hyperpolarization is a novel technique to enhance NMR signal of 13C labeled molecules > 10,000 times, which can visualize dynamic metabolic reactions in the body. Simultaneous imaging of exogenously administered multiple metabolic probes will make it possible to non-invasively detect the homeostasis disruption resulting from various diseases.


  1. Saito K, Matsumoto S, Takakusagi Y, Matsuo M, Morris HD, Lizak MJ, Munasinghe JP, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC. 13C-MR Spectroscopic Imaging with Hyperpolarized [1-13C]pyruvate Detects Early Response to Radiotherapy in SCC Tumors and HT-29 Tumors. Clin Cancer Res. 2015, 21(22), 5073-81
  2. Yasui H, Kawai T, Matsumoto S, Saito K, Devasahayam N, Mitchell JB, Camphausen K, Inanami O, Krishna MC. Quantitative imaging of pO2 in orthotopic murine gliomas: hypoxia correlates with resistance to radiation. Free Radic Res. 2017, 51(9-10), 861-871
  3. Takakusagi Y, Kishimoto S, Naz S, Matsumoto S, Saito K, Hart CP, Mitchell JB, Krishna MC. Radiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo Studies. Antioxid Redox Signal. 2018, 28(2), 131-140
  4. Kishimoto S, Matsumoto KI, Saito K, Enomoto A, Matsumoto S, Mitchell J, Devasahayam N, Krishna MC. Pulsed EPR imaging: Applications in the studies of tumor physiology. Antioxid Redox Signal. 2017, doi: 10.1089/ars.2017.7391. Epub ahead of print
  5. Amida T, Nakaoka R, Komarov DA, Yamamoto K, Inanami O, Matsumoto S, Hirata H. A 750-MHz electronically tunable resonator using microstrip line couplers for electron paramagnetic resonance imaging of a mouse tumor-bearing leg. IEEE Trans Biomed Eng. 2017, doi: 10.1109/TBME.2017.2743232. Epub ahead of print