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Elucidation of homeostatic mechanism by liver through production of hepatokines

Hirofumi Misu (photo)

Hirofumi Misu

Research Site Kanazawa University
Graduate School of Medical Sciences
Associate Professor

Content

To date, I have identified liver-derived secretory proteins associated with the pathology of obesity and type 2 diabetes, and have proposed that function-unknown liver-derived secretory proteins should be termed “hepatokines.” In this study, I aim to develop novel diagnostic and therapeutic methods for over-nutrition-related diseases targeting hepatokines by elucidating the systemic pleiotropic actions of hepatokines and by identifing the hepatokine receptors.

Publication

  1. H. Misu*, H. Takayama, Y. Saito, Y. Mita, A. Kikuchi, K. A. Ishii, K. Chikamoto, T. Kanamori, N. Tajima, F. Lan, Y. Takeshita, M. Honda, M. Tanaka, S. Kato, N. Matsuyama, Y. Yoshioka, K. Iwayama, K. Tokuyama, N. Akazawa, S. Maeda, K. Takekoshi, S. Matsugo, N. Noguchi, S. Kaneko and T. Takamura*. Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle. Nature Medicine 2017 23 508-516 *Co-corresponding author
  2. Y. Mita, K. Nakayama, S. Inari, Y. Nishito, Y. Yoshioka, N. Sakai, K. Sotani, T. Nagamura, Y. Kuzuhara, K. Inagaki, M. Iwasaki, H. Misu, M. Ikegawa, T. Takamura, N. Noguchi and Y. Saito. Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models. Nature Communications 2017 8(1) 1658
  3. K. Chikamoto, H. Misu*, H. Takayama, A. Kikuchi, K. A. Ishii, F. Lan, N. Takata, N. Tajima-Shirasaki, Y. Takeshita, H. Tsugane, S. Kaneko, S. Matsugo and T. Takamura*. Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice Biochem Biophys Res Commun 2016 478 1310-1316
    *Co-corresponding author
  4. M. Tanaka, Y. Saito, H. Misu, S. Kato, Y. Kita, Y. Takeshita, T. Kanamori, T. Nagano, M. Nakagen, T. Urabe, T. Takamura, S. Kaneko, K. Takahashi and N. Matsuyama. Development of a Sol Particle Homogeneous Immunoassay for Measuring Full-Length Selenoprotein P in Human Serum J Clin Lab Anal 2016 30 114-122
  5. N. Tajima-Shirasaki, K. A. Ishii, H. Takayama, T. Shirasaki, H. Iwama, K. Chikamoto, Y. Saito, Y. Iwasaki, A. Teraguchi, F. Lan, A. Kikuchi, Y. Takeshita, K. Murao, S. Matsugo, S. Kaneko, H. Misu and T. Takamura. Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes J Biol Chem 2017 292 10791-10800