Elucidation of homeostatic mechanism by liver through production of hepatokines
|Graduate School of Medical Sciences|
To date, I have identified liver-derived secretory proteins associated with the pathology of obesity and type 2 diabetes, and have proposed that function-unknown liver-derived secretory proteins should be termed “hepatokines.” In this study, I aim to develop novel diagnostic and therapeutic methods for over-nutrition-related diseases targeting hepatokines by elucidating the systemic pleiotropic actions of hepatokines and by identifing the hepatokine receptors.
- H. Misu*, H. Takayama, Y. Saito, Y. Mita, A. Kikuchi, K. A. Ishii, K. Chikamoto, T. Kanamori, N. Tajima, F. Lan, Y. Takeshita, M. Honda, M. Tanaka, S. Kato, N. Matsuyama, Y. Yoshioka, K. Iwayama, K. Tokuyama, N. Akazawa, S. Maeda, K. Takekoshi, S. Matsugo, N. Noguchi, S. Kaneko and T. Takamura*. Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle. Nature Medicine 2017 23 508-516 *Co-corresponding author
- Y. Mita, K. Nakayama, S. Inari, Y. Nishito, Y. Yoshioka, N. Sakai, K. Sotani, T. Nagamura, Y. Kuzuhara, K. Inagaki, M. Iwasaki, H. Misu, M. Ikegawa, T. Takamura, N. Noguchi and Y. Saito. Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models. Nature Communications 2017 8(1) 1658
- K. Chikamoto, H. Misu*, H. Takayama, A. Kikuchi, K. A. Ishii, F. Lan, N. Takata, N. Tajima-Shirasaki, Y. Takeshita, H. Tsugane, S. Kaneko, S. Matsugo and T. Takamura*. Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice Biochem Biophys Res Commun 2016 478 1310-1316
- M. Tanaka, Y. Saito, H. Misu, S. Kato, Y. Kita, Y. Takeshita, T. Kanamori, T. Nagano, M. Nakagen, T. Urabe, T. Takamura, S. Kaneko, K. Takahashi and N. Matsuyama. Development of a Sol Particle Homogeneous Immunoassay for Measuring Full-Length Selenoprotein P in Human Serum J Clin Lab Anal 2016 30 114-122
- N. Tajima-Shirasaki, K. A. Ishii, H. Takayama, T. Shirasaki, H. Iwama, K. Chikamoto, Y. Saito, Y. Iwasaki, A. Teraguchi, F. Lan, A. Kikuchi, Y. Takeshita, K. Murao, S. Matsugo, S. Kaneko, H. Misu and T. Takamura. Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes J Biol Chem 2017 292 10791-10800