Understanding and control of homeostatic dynamics affected by virus infection
Shingo Iwami
Research Site |
Kyushu University |
Department of Biology |
Associate Professor |
Content
The goal of this research are quantitative understanding of homeostatic dynamics affected by virus infection, and proposal for a new treatment for virus associated diseases. In particular, I focus on hepatitis B virus (HBV) infection, and carry out cell culture and animal experiments. In addition to analysis of these experimental data, I quantitatively analyze clinical data from HBV patients using mathematical models. Finally, I will establish a theory and propose a treatment for HBV cure.
Publication
- M. Mahgoub, *J. Yasunaga, S. Iwami, S. Nakaoka, Y. Koizumi, K. Shimura, and *M. Matsuoka. Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells, Proceedings of the National Academy of Sciences of the United States of America, In Press. (*Corresponding author)
- H. Ohashi, Y. Koizumi, K. Fukano, T. Wakita, AS. Perelson, *S. Iwami†, and *K. Watashi†. Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments, Proceedings of the National Academy of Sciences of the United States of America, 114: E4527-E4529 (2017). (†Equal contribution/*Corresponding author)
- Y. Koizumi, H. Ohashi, S. Nakajima, Y. Tanaka, T. Wakita, AS. Perelson, *S. Iwami†, and *K. Watashi†. Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection, Proceedings of the National Academy of Sciences of the United States of America, 114: 1922-1927 (2017). (†Equal contribution/*Corresponding author)
- A. Martyushev, S. Nakanoka, K. Sato, *T. Noda†, and *S. Iwami†. Modelling Ebola virus dynamics: Implications for therapy, Antiviral Research, 135: 62-73 (2016). (†Equal contribution/*Corresponding author)
- *S. Iwami†, JS Takeuchi†, S Nakaoka, F Mammano, F Clavel, H Inaba, T Kobayashi, N Misawa, K Aihara, Y Koyanagi, *K Sato. Cell-to-cell infection by HIV contributes over half of virus infection, Elife, 4, (2015). (†Equal contribution/*Corresponding author)