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Homeostasis and dynamism between vessel and stromal space

Satoshi Nishimura (photo)

Satoshi Nishimura

Research Site Jichi Medical University
Division of Cell and Molecular Medicine Center for Molecular Medicine
(Full) Professor


First steps for immunological reactions, blood productions, and inflammation in adult common diseases are usually limited to borderline space between vessel and stroma. In this proposal, I will develop intravital visualization and cell manipulaiton system, apply to the border space, and elucidate (patho-) physiological homeostasis by light.


  1. IL-1alph induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs Nishimura S, et al. J Cell Biology 2015 11;209(3):453-66.
  2. Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells
    Nishimura S, ,,, Nishimura S, Eto K. Cell Stem Cell, 2014 14(4):535-48
  3. ENPP2 contributes to adipose Tissue expansion and insulin resistance in diet-induced obesity Nishimura S, et al. Diabetes, 2014;63(12):4154-64
  4. Adipose natural regulatory B cells negatively control adipose tissue inflammation
    Nishimura S,, et al Cell Metabolism. 2013, 18, 759-766.
  5. Alendronate inhalation ameliorates elastase-induced pulmonary emphysema in mice by induction of apoptosis of alveolar macrophages Ueno M, Maeno T, Nishimura S, et al. Nat Commun. 2015 10;6:6332.