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Novel crosstalk between brain and peripheral organs for maintaining homeostasis

Kazuhiro Nakamura (photo)

Kazuhiro Nakamura

Research Site Nagoya University
Graduate School of Medicine


The brain-periphery crosstalk, which is incessant communications between brain and peripheral organs, is a fundamental component in the homeostatic system that underlies the maintenance of our life. This research project aims at revealing the core mechanism in the brain-periphery crosstalk by applying in vivo physiology, optogenetics and neuroanatomy to our originally created transgenic rats. We hope this research contributes to future development of epoch-making therapies for various diseases caused by failure in the homeostatic system.


  1. Nakamura, Y., Yanagawa, Y., Morrison, S.F., Nakamura, K. Medullary reticular neurons mediate neuropeptide Y-induced metabolic inhibition and mastication. Cell Metabolism, 2017, 25:322-334.
  2. Kataoka, N., Hioki, H., Kaneko, T., Nakamura, K. Psychological stress activates a dorsomedial hypothalamus-medullary raphe circuit driving brown adipose tissue thermogenesis and hyperthermia. Cell Metabolism, 2014, 20:346-358.
  3. Lkhagvasuren, B., Oka, T., Nakamura, Y., Hayashi, N., Sudo, N., Nakamura, K. Distribution of Fos-immunoreactive cells in rat forebrain and midbrain following social defeat stress and diazepam treatment. Neuroscience, 2014, 272:34-57.