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Investigation of functional link between the innate immune and metabolic/endocrine systems in the pathogenesis of metabolic syndrome

Yoshinori Nagai (photo)

Yoshinori Nagai

Research Site University of Toyama
Graduate School of Medicine and Pharmaceutical Science for Research
Professor

Content

The immune system is an important regulatory system that involves the maintenance of homeostasis in the living body by sensing exogenous and endogenous substances in various tissues and organs. In this project, I focus on pattern recognition receptors in the innate immune system and investigate their regulatory roles in pathogenesis of obesity-associated metabolic dysfunctions. This approach will help to understand the molecular mechanisms by which the immune system regulates homeostasis of the metabolic/endocrine system in a physiological setting.

Publication

  1. Honda H, Nagai Y, Matsunaga T, Okamoto N, Watanabe Y, Tsuneyama K, Hayashi H, Fujii I, Ikutani M, Hirai Y, Muraguchi A, Takatsu K. Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. J Leukoc Biol 96(6), 1087-1100, 2014
  2. Yanagibashi T, Nagai Y, Watanabe Y, Ikutani M, Hirai Y, Takatsu K. Differential requirements of MyD88 and TRIF pathways in TLR4-mediated immune responses in murine B cells. Immunol Lett 163(1), 22-31, 2015
  3. Nakamura T, Nishibu A, Yoshida N, Yasoshima M, Anzawa K, Watanabe Y, Nagai Y, Takatsu K, Ogawa K, Mochizuki T. Glycyrrhetinic acid inhibits contact hypersensitivity induced by trichophytin via dectin-1. Exp Dermatol 25, 299-304, 2016
  4. Watanabe Y, Nagai Y, Honda H, Okamoto N, Yamamoto S, Hamashima T, Ishii Y, Tanaka M, Suganami T, Sasahara M, Miyake K, Takatsu K. Isoliquiritigenin attenuates adipose tissur inflammation in vitro and adipose tissue fibrosis through inhibition of innate immune responses in mice. Sci Rep 6, 23097; doi:10.1038/srep23097, 2016
  5. Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, Arif A, Senda S, Tsuneyama K, Ikutani M, Watanabe Y, Igarashi Y, Nagai Y, Takatsu K, Koizumi K, Imura J, Goda N, Sasahara M, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe K. HIF-1α in myeloid cells promotes adipose tissue remodeling toward insulin resistance. Diabates 65(12), 3649-3659, 2016
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