Elucidation of metabo-physiological network function integrated among brain, peripheral tissues and time
||Tokushima University Graduate School|
|Institute of Biomedical Sciences|
Energy metabolism in our biological body is well controlled by brain via nervous system and/or humoral pathway. In addition, "Time", such as intra-individual energy condition, timing of environmental stimulus and life-stage, has an impact not only on central regulation of energy metabolism but also on higher brain function, however, its each molecular basis remains unclear. In this research, I aim to investigate the role of key molecule and pathway among each tissues in inter-organ communication under physiological and pathological condition and to understand the metabo-physiological network mechanism accompanied with an element of time.
- Miyatake Y, Shiuchi T (equal contribution), Mawatari K, Toda S, Taniguchi Y, Futami A, Sato F, Kuroda M, Sebe M, Tsutsumi R, Harada N, Minokoshi Y, Kitamura T, Gotoh K, Ueno M, Nakaya Y, Sakaue H. Intracerebroventricular injection of ghrelin decreases wheel running activity in rats. Peptides. 2017 Jan;87:12-19.
- Oura K, Otsuka A, Shiuchi T (Corresponding author), Chikahisa S, Shimizu N, Séi H. Late feeding in the active period decreases slow-wave activity., Life Sci. 2016 Sep 1;160:18-26.
- Otsuka A, Shiuchi T (Corresponding author), Chikahisa S, Shimizu N, Séi H. Voluntary exercise and increased food intake after mild chronic stress improve social avoidance behavior in mice., Physiol Behav. 2015 Nov 1;151:264-71.