Exploratory research on the molecular mechanism of cardiovascular homeostasis through myocardial-endothelial signaling
||National Cerebral and Cardiovascular Center|
The interaction between endothelium and myocardium mediated by humoral factors has important roles in cardiovascular homeostasis and development. We recently found that the interaction between endothelium and myocardium through angiopoietin-1 plays a critical role in the coronary vessel formation. The present study aims to reveal the physiological and pathological role of myocardium-derived angiopoietin-1 in the coronary angiogenesis and pulmonary arterial hypertension. The findings obtained from the present study will help us develop novel therapeutic strategies for the related cardiovascular diseases.
- Hashimoto-Kataoka T, Hosen N, Sonobe T, Arita Y, Yasui T, Masaki T, Minami M, Inagaki T, Miyagawa S, Sawa Y, Murakami M, Kumanogoh A, Yamauchi-Takihara K, Okumura M, Kishimoto T, Komuro I, Shirai M, Sakata Y, Nakaoka Y.* Interleukin-6/interleukin-21-signaling axis is critical in the pathogenesis of pulmonary arterial hypertension. Proc Natl Acad Sci U S A. 2015 May 19; 112(20): E2677-86. doi: 10.1073/pnas.1424774112. Epub 2015 May 4. (*corresponding author)
- Arita Y, Nakaoka Y*, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Hashimoto-Kataoka T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kurihara H, Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y, Yamashita JK, Komuro I. Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart. Nature Communications 2014 Jul 29; 5: 4552. doi: 10.1038/ncomms5552. (*corresponding author)