|Research Site||Kyushu University|
|Medical Institute of Bioregulation|
Blood insulin exhibits several temporal patterns. It has been reported that insulin secretion abnormalities are related to the pathogenesis of type 2 diabetes mellitus (T2DM). This observation suggests that one of the reasons for pathogenesis of T2DM is collapse of insulin homeostasis caused by impaired temporal patterns of insulin. In this study, I would like to reveal the mechanisms how the temporal patterns of insulin involve the pathogenesis of T2DM using systems biology approaches.