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Investigation of insulin homeostasis through temporal patterns of insulin

Hiroyuki Kubota (photo)

Hiroyuki Kubota

Research Site Kyushu University
Medical Institute of Bioregulation


Blood insulin exhibits several temporal patterns. It has been reported that insulin secretion abnormalities are related to the pathogenesis of type 2 diabetes mellitus (T2DM). This observation suggests that one of the reasons for pathogenesis of T2DM is collapse of insulin homeostasis caused by impaired temporal patterns of insulin. In this study, I would like to reveal the mechanisms how the temporal patterns of insulin involve the pathogenesis of T2DM using systems biology approaches.


  1. Sano T., Kawata K., Ohno S., Yugi K., Kakuda H., Kubota H., Uda S., Fujii M., Kunida K., Hoshino D., Hatano A., Ito Y., Sato M., Suzuki Y., and Kuroda S.
    Selective control of up-regulated and down-regulated genes by temporal patterns and doses of insulin., 2016, Sci. Signal., 9(455): ra112
  2. Yugu, K., Hiroyuki, K., et. al co-first, Reconstruction of insulin signal flow from phosphoproteome and metabolome data., 2014 Cell. Rep. 8, 1-13