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Manifestation of psychological behaviors due to systemic disorders. -From immunological status to neural circuits-

Hiroaki Wake (photo)

Hiroaki Wake

Research Site Kobe University
Graduate School of Medicine


Psychological behaviors are not only caused by the psychological disease, but also arise from systemic disorders such as auto-immune disease, cancer or aging. The aim of this study is; 1) identify how systemic disorder impacts on a immune status both in systemic circulation and central nervous system(CNS), and 2) to study the mechanism by which CNS immune cell homeostasis of the synapse function and myelination is effected in these disorders. These experiments will help determine/understand how psychiatric behaviors can be caused by systemic diseases.


  1. Miyamoto A, Wake H, Ishikawa AW, Eto K, Shibata K, Murakoshi H, Koizumi S, Moorhouse AJ, Yoshimura Y, Nabekura J. Microglia contact induces synapse formation in developing somatosensory cortex. Nature Commun. 2016. Aug 25;7:12540. (IF=11.470 CI=0)
  2. Kato G, Inada H, Wake H, Akiyoshi R, Miyamoto A, Eto K, Ishikawa T, Moorhouse AJ, Strassman AM, Nabekura J. Microglial Contact Prevents Excess Depolarization and Rescues Neurons from Excitotoxicity. eNeuro. 2016 Jun 21;3(3). pii: ENEURO.0004-16.2016. doi: 10.1523/ENEURO.0004-16.2016. eCollection 2016 May-Jun. (査読あり)
  3. Wake H, Ortiz FC, Woo DH, Lee PR, Angulo MC, Fields RD. Non-synaptic junctions on myelinating glia promote preferential myelination of electrically-active axons. Nature Commun. 2015. Aug 4;6:7844. (IF=11.470 CI=0)