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Elucidation of the role of cardiovascular system in the central nervous system disorders

Rieko Muramatsu (photo)

Rieko Muramatsu

Research Site Osaka University
Department of Molecular Neuroscience, Graduate School of Medicine
Associate Professor


Central nervous system injury leads to the disruption of neural network causing neurological deficits. These deficits are spontaneously recovered because the neuronal cells can contribute to tissue repair. In this project, we focus on the role of the cardiovascular system in the repair process after central nervous system injury. The results obtained will aid to develop novel therapeutic strategy for the central nervous system disorders.


  1. Kuroda, M., Muramatsu, R.(co-corresponding author), Maedera, N., Koyama, Y., Hamaguchi, M., Fujimura, H., Yoshida, M., Konishi, M., Itoh, N., Mochizuki, H. and Yamashita, T. (2017) Peripherally derived FGF21 promotes remyelination in the central nervous system. J. Clin. Invest., 127, 3496-3509.
  2. Matoba, K., Muramatsu, R.(co-corresponding author) and Yamashita, T. (2017) Leptin sustains spontaneous remyelination in the adult central nervous system. Sci. Rep., 7, 40397.
  3. Kuroda, M., Muramatsu, R.(co-corresponding author) and Yamashita, T. (2017) Cardiomyocyte-released factors stimulate oligodendrocyte precursor cells proliferation. Biochem. Biophys. Res. Commun., 482, 1160-1164.
  4. Muramatsu, R.(co-corresponding author), Kuroda, M., Matoba, K., Lin, H., Takahashi, C., Koyama, Y., Yamashita, T. (2015) Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system. J. Biol. Chem., 290, 11515-11525.
  5. Miyake, S., Muramatsu, R.(co-corresponding author), Hamaguchi, M. and Yamashita, T. (2015) Prolyl hydroxylase regulates axonal rewiring and motor recovery after traumatic brain injury. Cell Death Dis., 6, e1638