HOME > Research Areas by Category > Elucidation of the Principles ...

Elucidation of the Principles of Formation and Function of the Brain Neural Network and Creation of Control Technologies

Research Supervisor
Seiji Ozawa
Professor, Takasaki University of Health and Welfare
Year Started


This research area aims to elucidate the molecular and cellular mechanisms of the generation, development, and regeneration of the brain neural network; to investigate how neural networks composed of a variety of elements in individual brain areas work and express their specific functions; and to clarify how the brain works as a coherent system by integrating the activities of these local networks. On the basis of such research, it also aims to create technologies for controlling the process of formation and activities of the brain neural network.
Specific approaches may include elucidation of the molecular mechanisms of development, differentiation, regeneration, target recognition, and migration of neurons (components of neural networks) and glial cells that significantly influence neural network formation and functions; elucidation of the mode of neural network activities by combining new technologies, such as visualization of specific neurons with the use of specific expression molecules and fluorescent proteins, simultaneous recording of activities of many neurons, and local stimulation with a caged compound; research to clarify the relationship of higher order brain functions with synaptic events through the combination of research at the network and system levels in model animals and research on the regulatory mechanism of synaptic transmission at the molecular and cellular levels; elucidation of the mechanism of neural network reorganization at the critical period or after brain damage; and creation of technologies for intervention in its process.

Strategic Sector

Clarification of the Control Mechanisms of Neural Circuit Operation and its Formation

Research Projects

Year Started : 2011
Research DirectorAffiliationResearch Project
Junichi Nabekura Professor, National Institute for Physiological Sciences Neuron-glia interaction in long-term remodeling of synapses in vivo
Eiji Hoshi Project Leader, Tokyo Metropolitan Institute of Medical Science Modes of motor information processing in primate cerebro-cerebello-basal ganglia networks
Yasushi Miyashita Professor, The University of Tokyo Neurophysiological investigation of mechanisms of cognitive memory network in the cerebral cortex of macaques
Takeshi Yagi Professor, Osaka University Neuronal individuality providing neural circuit formation and cell assembly
Year Started : 2009
Research DirectorAffiliationResearch Project
Hitoshi Okamoto Deputy Director/ Senior Team Leader, RIKEN Brain Science Institute Study on the regulatory mechanisms for behavioral and learning choices by the habenula
Yasuo Kawaguchi Professor, National Institute for Physiological Sciences Integrative analysis of inter-region and local circuit connections in the cerebral cortex
Yukiko Gotoh Professor, The University of Tokyo Production of various neural cell types by regulation of neural stem cells
Tomoyuki Takahashi Professor, Doshisha University Presynaptic regulatory mechanism in neuronal communication and its postnatal development
Takahisa Furukawa Head, Osaka Bioscience Institute Analysis of the synapse formation and the functional networks in the vertebrate retina
Masanori Matsuzaki Professor, National Institute for Basic Biology Spatio-temporal representation of the motor information in the brain revealed by cutting-edge techniques
Hajime Mushiake Professor, Tohoku University Neural mechanisms underlying dynamic representations of information in the brain: state transitions in local circuits
Kensaku Mori Professor, The University of Tokyo Neuronal circuit mechanisms underlying odor-induced motivational and emotional behaviors
Michisuke Yuzaki Professor, Keio University Role of C1q family signaling in regulation of synapse formation in mature brain
Research Areas by Category
Research Areas Completed
Researcher Index