Production of various neural cell types by regulation of neural stem cells

Research Project Outline

In the cerebral cortex, different neuronal cell types are generated in a temporally defined sequence and constitute the cortical layers; neural stem cells then switch off neuron production to make glial cells. We will study epigenetic mechanisms that underlie this temporal regulation of neural stem cell fate during development. We will also study the origin of adult neural stem cells, and try to find a way to activate this population and incorporate them into the neuronal network.