Research Project Outline
The brain dynamically adapts its function in response to changes in the internal and external environment. Reorganization of neural circuits and synaptic connections between neurons are the key processes that underlie changes in brain function. It has been technically difficult to observe these changes in circuits and synapses in living animals. Therefore, in this study, we utilize two-photon microscopy, a technique that allows imaging of neurons and synapses in living animals over time. We specifically focus on the role of microglia and astrocytes in reorganization of synapses and neural circuits. We aim to reveal the underlying mechanisms by which the brain adapts to its environment and the role of the neuron-glia interactions in this neuronal plasticity.
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