Modes of motor information processing in primate cerebro-cerebello-basal ganglia networks

Research Project Outline

This study aims to elucidate the neural mechanisms that underlie voluntary motor control driven by networks linking the motor-related areas in the cerebral cortex, cerebellum, and basal ganglia. To address this issue, we adopt three distinct approaches in primates. For structural analyses, we investigate the network architecture surrounding the primary motor cortex using novel anatomical methods, such as transneuronal labeling with rabies virus. For functional analyses, we examine the neuronal activity pattern simultaneously recorded from multiple brain regions in monkeys performing motor tasks, thereby elucidating the functional framework of the brain in which a final motor command is synthesized. For pathophysiological analyses, we investigate the relationship between behavioral changes in motor execution and dysfunction of each brain region or inter-regional connection.

Research Director
Project Leader, Tokyo Metropolitan Institute of Medical Science
Research Started
Research Area
Elucidation of the Principles of Formation and Function of the Brain Neural Network and Creation of Control Technologies
Research Areas by Category
Research Areas Completed
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