Role of C1q family signaling in regulation of synapse formation in mature brain

Research Project Outline

Neuronal activities induce morphological changes at synapses throughout adulthood. This process is considered as a basis for long-lasting memory. In this study, we will elucidate roles of C1q family proteins in regulation of synapse formation and maintenance in adult brain. Furthermore, we will develop a method to modify neuronal circuits and its associated behaviors in vivo by regulating the C1q family signaling. The findings of these studies will have therapeutic potentials against synapse losses, which are known to occur during aging and under certain pathological conditions.