Integrative analysis of inter-region and local circuit connections in the cerebral cortex

Research Project Outline

Neurons from discrete neocortical areas send axons near and far to numerous subcortical and cortical targets. The great diversity of neocortical neurons allows some neuron subtypes to specialize in specific projection pathways. Our research will characterize the connection specificity between cortical neuron subtypes and their projection targets. Furthermore, we will test the hypothesis that the local synaptic connectivity between inhibitory and excitatory neurons depends upon the projection targets.