Elucidation of mechanisms of neural network reorganization and functional recovery after brain injury

Research Project Outline

Initial behavioral deficits resulting from brain injury are frequently followed by spontaneous recovery of function. The basis of this behavioral plasticity is not fully understood, although neural network reorganization is expected to contribute to this resilience. It has been noted that synaptic plasticity within pre-existing pathways and formation of new circuits through collateral sprouting of both lesioned and unlesioned fibers are important components of the spontaneous recovery process, although the molecular mechanisms of these phenomena are poorly understood. We aim to elucidate the mechanisms underlying this plasticity, knowledge of which will contribute to enhancement of functional recovery after injury to the central nervous system.

Related Links

• Laboratory Website: http://www.med.osaka-u.ac.jp/pub/molneu/index_e.html