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Elucidation of the molecular basis of signaling cascades underlying plastic neuronal circuits via development of new probing and control technologies

Research Project Outline

Previous work has established that neuronal circuits comprise two kinds of connections: hardwired circuits that are genetically programmed and plastic circuits whose connectivity is strengthened in an experience-dependent manner. In this project, we will investigate the molecular basis of the activity dependence of plastic circuits at both the synapse and system levels using novel imaging techniques. Based on these findings, we will further develop new molecular tools to deconstruct, reconstruct, and control the function of plastic circuits.

Research Director
HaruhikoBito
Affiliation
Associate Professor and Department Head, The University of Tokyo
Research Started
2010
Status
ongoing
Research Area
Elucidation of the Principles of Formation and Function of the Brain Neural Network and Creation of Control Technologies
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