Presynaptic regulatory mechanism in neuronal communication and its postnatal development

Research Project Outline

By introducing molecular tools and manipulations to giant presynaptic terminals and glia, visualized in slices and cultures, we investigate dynamic changes of electrical/Ca signals and movements of intracellular organella in association with neuronal activity, thereby clarifying how presynaptic molecules regulate transmitter release, and how they are involved in developmental and activity-dependent changes of synaptic function. Through this study, we aim at providing a novel basic insight into the molecular mechanism underlying neuronal communication, thereby contributing to clinical studies pursuing new treatments for neuronal diseases.