Research Director

Hideki Katagiri, M.D., Ph.D.

Tohoku University
Professor
website

Outline

We have discovered several neuronal relay systems responsible for inter-organ metabolic communication to maintain systemic homeostasis in multi-organ organisms including humans. Based on our original discoveries, we will investigate the mechanisms underlying coordinated regulation of metabolism in different organs/tissues by the brain and the roles of inter-organ metabolic communication in obesity- and aging-related metabolic disorders. In addition, using human samples, we will examine whether these systems functionally works in human subjects and search for chemical reagents which can control these systems. These investigations are anticipated to provide potential targets for developing preventive and therapeutic strategies.