Research Director
Tamotsu Yoshimori, Ph.D.
Osaka University
Professor
website
Outline
Hypernutrition disturbs physiological homeostasis maintained by a coordinated network of endocrine, metabolic, and immune systems, which causes obesity-related diseases including diabetes and elevated risk of infection. The multi-organ network is maintained by autophagy, an intracellular cleaning system and its activity is down or falls short by hypernutrition-caused stresses. In this study, we aim to unravel mechanisms underlying collapse of homeostasis caused by autophagy dysfunction under hypernutrient condition and develop new therapeutic strategy for obesity-caused diseases based on autophagy regulation.
