Research Director

Yuichi Oike, M.D., Ph.D.

Kumamoto University
Professor
website

Outline

Stresses derived from aging and lifestyle changes cause tissue damages. These damages are generally repaired by homeostatic mechanisms, in which various types of cells react to stresses and promote tissue remodeling through intercellular communication, thereby maintaining tissue homeostasis. However, alteration of these mechanisms leads to the pathologic tissue remodeling and results in pathogenesis and progression of lifestyle diseases. In this study, we aim to clarify the molecular mechanisms underlying pathogenesis and progression of lifestyle diseases from point of view of “crosstalk between tissue repair and immune response” and to develop novel preventive, diagnostic, and therapeutic strategies for lifestyle diseases.