Research Director

Shu Takeda, M.D., Ph.D.

Tokyo Medical and Dental University
Professor
website

Outline

It has been revealed that bone is not just a passive organ working against gravity, but, indeed, an active organ affecting whole-body energy metabolism. In this project, we will further develop our recent discovery that bone and central nervous system communicate with each other: we will address the molecular basis for the inter-organ metabolic network, such as brain, fat and kidney, with a focus on bone as a hub. We aim to elucidate a molecular mechanism for maintaining whole-body homeostasis in multi-organ animal and develop a novel preventive and therapeutic approach for bone degenerative disease and metabolic disease.