2014年9月18日
妻木チームの研究成果の論文がNature誌に掲載され、「スタチンが軟骨無形成症の病態を回復〜疾患特異的ｉＰＳ細胞モデルによるドラッグ・リポジショニングの可能性〜」と題してプレス発表されました。→プレス発表
"Statin treatment rescues FGFR3 skeletal dysplasia phenotypes."→掲載論文　abstract(Pubmed)

2014年6月13日
花園チームの研究成果の論文がPLOS ONE誌に掲載されました。
"MHC-Matched Induced Pluripotent Stem Cells Can Attenuate Cellular and Humoral Immune Responses but Are Still Susceptible to Innate Immunity in Pigs."→掲載論文　abstract(Pubmed)

2014年6月11日
家田チームの研究成果の論文がEMBO J.誌に掲載され、「短期間かつ効率的な心筋様細胞直接作製法の確立と仕組みを解明〜細胞作製技術や再生医療への応用に期待〜」と題して慶應義塾大学よりプレス発表されました。→プレス発表
"MiR‐133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures."→掲載論文　abstract(Pubmed)

2014年2月26日
佐谷チームの研究成果の論文がNature Communications誌に掲載され、「アクチン細胞骨格の動態が脂肪分化を誘導するメカニズムを解明」と題してプレス発表されました。→プレス発表
"Regulation of MKL1 via actin cytoskelton dynamics drives adipocyte differentiation."→掲載論文abstract(Pubmed)

2014年2月7日
石井チームの研究成果の論文がCell Stem Cell誌に掲載され、「卵子の「異型ヒストン」がｉＰＳ細胞の作製を促す」と題してプレス発表されました。→プレス発表
"Histone Variants Enriched in Oocytes Enhance Reprogramming to Induced Pluripotent Stem Cells."→掲載論文abstract(Pubmed)

2013年12月13日
江良チーム西中村グル―プの研究成果の論文がCell Stem Cell誌に掲載され、「世界で初めてヒトｉＰＳ細胞から３次元腎臓組織作成に成功」と題してプレス発表されました。→プレス発表
"Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells."→掲載論文　abstract(Pubmed)

2013年10月17日
妻木チームの研究成果がPLOS ONE誌に掲載され、「ヒトの皮膚細胞から軟骨様細胞へ直接変換に成功」と題してプレス発表されました。→プレス発表
"Direct induction of chondrogenic cells from human dermal fibroblast culture by defined factors."→掲載論文abstract(Pubmed)

2013年10月10日
花園チーム長嶋グループの研究成果がPLOS ONE誌に掲載され、「効率的な方法で、短期間に免疫のないブタを作ることに成功」と題してプレス発表されました。→プレス発表
"Generation of Interleukin-2 Receptor Gamma Gene Knockout Pigs from Somatic Cells Genetically Modified by Zinc Finger Nuclease-Encoding mRNA."→掲載論文abstract(Pubmed)

2013年9月19日
井上チーム須原グル―プの研究成果の論文がNeuron誌に掲載され、「認知症で神経細胞死を引き起こす異常タンパク質の生体での可視化に世界で初めて成功」と題してプレス発表されました。→プレス発表
"Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls."→掲載号abstract(Pubmed)

2013年7月30日
米田チームの研究成果の論文がDevelopmental Cell誌に掲載され、「哺乳類ＥＳ細胞の新たな未分化維持機構を発見〜幹細胞研究や再生医療への新たな展開に期待〜」と題してプレス発表されました。→プレス発表
"Importin Alpha Subtypes Determine Differential Transcription Factor Localization in Embryonic Stem Cells Maintenance."→掲載号abstract(Pubmed)

2013年7月16日
家田チームの研究成果の論文がPNAS誌に掲載され、「ヒトの心臓線維芽細胞から心筋様細胞を直接作製することに成功」と題してプレス発表されました。→プレス発表
"Induction of Human Cardiomyocyte-like Cells from Fibroblasts by Defined Factors."→掲載号abstract(Pubmed)

2013年7月3日
千住チームの研究成果の論文がPLOS ONE誌に掲載され、「ヒトiPS 細胞由来の免疫細胞を用いた癌の腹膜播種（癌性腹膜炎）の治療法の開発」と題してプレス発表されました。→プレス発表
"Therapeutic Effect of Human iPS-Cell?Derived Myeloid Cells Expressing IFN-β against Peritoneally Disseminated Cancer in Xenograft Models."→掲載号abstract(Pubmed)

2013年6月7日
篠原チームの研究成果の論文がCell Stem Cell誌に掲載され、「活性酸素の精子幹細胞に対する増殖促進作用を解明」と題してプレス発表されました。→プレス発表
"ROS Are Required for Mouse Spermatogonial Stem Cell Self-Renewal."→掲載号abstract(Pubmed)

2013年2月22日
井上チームの研究成果の論文がCell Stem Cell誌に掲載され、「患者さん由来ｉＰＳ細胞でアルツハイマー病の病態を解明　ｉＰＳ細胞技術を用いた先制医療開発へ道筋」と題してプレス発表されました。→プレス発表
"Modeling Alzheimer's disease using iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness."→掲載号abstract(Pubmed)

2013年1月21日
花園チームの研究成果がStem Cells and Development誌に掲載され、表紙を飾りました。→掲載表誌
"Generation of Naive-Like Porcine-Induced Pluripotent Stem Cells Capable of Contributing to Embryonic and Fetal Development."→掲載号abstract(Pubmed)

2013年1月4日
古関チームの研究成果の論文がCell Stem Cell誌に掲載され、「がん細胞を殺すT細胞をiPS細胞化し若く元気なT細胞に再生?がんの免疫療法を革新する可能性?」と題してプレス発表されました。→プレス発表
"Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8+ T Cells."→掲載号abstract(Pubmed)

2012年9月3日
黒川チームの研究成果の論文がBlood誌に掲載され、研究成果に関連してJSTの広報誌「JST NEWS」に「特集１ がん治療薬開発の新展開」と題して掲載されました。→掲載記事
"Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples."→掲載号abstract(Pubmed)

2012年8月29日
家田チームの研究成果がCirculation Research誌に掲載され、「生体内で線維芽細胞から心筋細胞を直接作製することに成功―心筋梗塞をはじめとする心臓疾患に対する新たな再生医療の実現へ期待」と題してプレス発表されました。→プレス発表
"Induction of Cardiomyocyte-like Cells in Infarct Hearts by Gene Transfer of Gata4, Mef2c, and Tbx5."→掲載号abstract(Pubmed)

2012年8月2日
井上チームの研究成果がScience Translational Medicine誌に掲載され、「患者さん由来ｉＰＳ細胞でＡＬＳ病態解明・治療薬シーズを発見」と題してプレス発表されました。→プレス発表
"Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells."→掲載号abstract(Pubmed)

2012年6月7日
佐谷チームの研究成果の論文がNature Communications誌に掲載され、「癌幹細胞マーカーＣＤ４４の発現が乳癌の肺への転移を促進するメカニズムを解明 - 転移性乳癌細胞を標的とした治療法確立・治療薬開発に期待 - 」と題してプレス発表されました。→プレス発表
"Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell."→掲載号abstract(Pubmed)
※この研究成果に関連して、JSTの広報誌「JSTNEWS」9月号に記事が掲載されました。掲載ページ

2011年11月4日
篠原チームの研究成果の論文がCell Stem Cell誌に掲載され、「マウス精子幹細胞移植における細胞生着メカニズムを解明（効率的な細胞移植技術につながる可能性）」と題して発表されました。→発表
"Rac mediates mouse spermatogonial stem cell homing to germline niches by regulating transmigration through the blood-testis barrier"→掲載号abstract(Pubmed)

2011年8月5日
斎藤チームの研究成果の論文がCell誌に掲載され、「多能性幹細胞で作製した生殖細胞に由来するマウスの産出に成功（生殖細胞形成メカニズムの解明、不妊症の原因究明などに貢献）」と題してプレス発表されました。→プレス発表
"Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells"→掲載号　abstract(Pubmed)
2012年1月6日
本成果が、Cell誌のResearch Highlight of 2011に選ばれました。→Cell

2011年7月8日
奥田チームの研究成果の論文がCell Stem Cell誌に掲載され、「がん原因遺伝子の働きなしでＥＳ細胞の多能性を維持する仕組みを発見（ＥＳ細胞やｉＰＳ細胞の安全性向上につながる可能性）」と題してプレス発表されました。→プレス発表
"Indefinite Self-Renewal of ES Cells through Myc/Max Transcriptional Complex-Independent Mechanisms"→掲載号abstract(Pubmed)

2011年3月15日
佐谷チームの研究成果の論文がCancer Cell誌に掲載され、「癌幹細胞マーカーCD44が活性酸素を抑制することによって腫瘍の増大や治療が効かない状況を引き起こす分子メカニズムを解明」と題してプレス発表されました。→プレス発表
"CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc- and Thereby Promotes Tumor Growth "→掲載号abstract(Pubmed)

2011年1月11日
妻木チームの研究成果の論文がThe Journal of Clinical Investigation誌に掲載され、「マウスの皮膚細胞から硝子軟骨様組織を直接得ることに成功（ｉＰＳ細胞を経由しないで、再生困難な軟骨を回復できる機構）」と題して紹介いたしました。→情報ページ
"Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors"　→掲載号abstract(Pubmed)
※この研究成果に関連して、JSTの広報誌「JSTNEWS」に記事が掲載されています。掲載ページ

2010年6月2日
古関チームの研究成果の論文がThe Journal of Clinical Investigation誌に掲載され、「「多能性幹細胞」ｉＰＳ細胞から免疫治療に「役に立つ」リンパ球を作製−抗がん効果を発揮するＮＫＴ細胞だけを作ることに世界で初めて成功−」と題してプレス発表されました。→プレス発表
"Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells"　→掲載号abstract(Pubmed)
※この研究成果に関連して、JSTの広報誌「JSTNEWS」に記事が掲載されています。掲載ページ

2010年3月5日
岩間チームの研究成果の論文がCell Stem Cell誌に掲載され(Volume6,Issue3,P279-286)、「造血幹細胞の多能性を維持する仕組み発見　ES/iPS細胞と同様の遺伝子抑制が重要な役割　（幹細胞を誘導・分化させる操作技術の改良に寄与する新知見）」と題してプレス発表されました。→プレス発表
"Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1"　→掲載号abstract(Pubmed)
※この研究成果に関連して、JSTの広報誌「JSTNEWS」に記事が掲載されています。掲載ページ

2009年12月9日
押村チームの研究成果の論文がMolecular Therapy誌に掲載され(Volume18,Issue2,P386-393)、「筋ジストロフィー患者由来のiPS細胞における遺伝子修復に成功（ヒト人工染色体ベクターによる新たな遺伝子治療戦略の可能性）」と題してプレス発表されました。→プレス発表
"Complete genetic correction of iPS cells from Duchenne muscular dystrophy"　→掲載号abstract(Pubmed)

2009年7月2日
丹羽チームの研究成果の論文がNature誌に掲載されました(Volume460,Number7251,P118-122)。→掲載号
"A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells"→abstract(Pubmed)
→日本語要約

2009年7月2日
篠原チームの研究成果の論文がCell Stem Cell誌に掲載されました(Volume5,Issue1,P76-86)。→掲載号
"Genetic Reconstruction of Mouse Spermatogonial Stem Cell Self-Renewal In Vitro by Ras-Cyclin D2 Activation"→abstract(Pubmed)
→京都大学でのプレス発表

石井チーム
○Maekawa T, Kim S, Nakai D, Makino C, Takagi T, Ogura H, Yamada K, Chatton B and Ishii S. Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene. EMBO J. 2010;29:196-208. [PMID:19893493]
○Staton TL, Lazarevic V, Jones DC, Lanser AJ, Takagi T, Ishii S and Glimcher LH. Dampening of death pathways by Schnurri-2 is essential for T cell development. Nature. 2011;472:105-109. [PMID:21475200]
○Nagao M, Saita Y, Hanyu R, Hemmi H, Notomi T, Hayata T, Nakamoto T, Nakashima K, Kaneko K, Kurosawa H, Ishii S, Ezura Y and Noda M. Schnurri-2 deficiency counteracts against bone loss induced by ovariectomy. J. Cell. Physiol. 2011;226:573-578. [PMID:21069746]
○Egoh A, Nosuke Kanesashi S, Kanei-Ishii C, Nomura T and Ishii S. Ribosomal protein L4 positively regulates activity of a c-myb proto-oncogene product. Genes Cells 2010;15:829-841. [PMID:20604807]
○Jones DC, Schweitzer MN, Wein M, Sigrist K, Takagi T, Ishii S and Glimcher LH. Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3. Proc. Natl. Acad. Sci. USA. 2010;107:8254-8258. [PMID:20404140]
○Maekawa T, Jin W and Ishii S. The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors. Mol. Cell. Biol. 2010;30:613-625. [PMID:19948881]
○Seong KH, Li D, Shimizu H, Nakamura R and Ishii S. Inheritance of stress-induced, ATF-2-dependent epigenetic change. Cell 2011;145:1049-1061. [PMID:21703449]

岩間チーム
○Yamazaki S, Iwama A, Takayanagi SI, Eto K, Ema H and Nakauchi H. TGF-β as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Blood. 2009;113:1250-56. [PMID:18945958]
○Chiba T, Miyagi S, Saraya A, Aoki R, Seki A, Morita Y, Yonemitsu Y, Yokosuka O, Taniguchi H, Nakauchi H and Iwama A. The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma. Cancer Res. 2008;68:7742-49 [PMID:18829528]
○Yashiro Y, Bannai H, Yabiku T, Minowa T, Miyano S, Osawa M, Iwama A and Nakauchi H. Transcriptional profiling of hematopoietic stem cells by high-throughput sequencing. Int J Hematol. 2009;89:24-33 [PMID:19050837]
○Ku M, Koche RP, Rheinbay E, Mendenhall EM, Endoh M, Mikkelsen TS, Presser A, Nusbaum C, Xie X, Chi AS, Adli M, Kasif S, Ptaszek LM, Cowan CA, Lander ES, Koseki H and Bernstein BE. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet. 2008;4:e1000242[PMID:18974828]
○Fukushima K, Matsumura I, Ezoe S, Tokunaga M, Yasumi K, Satoh Y, Shibayama H, Tanaka H, Iwama A and Kanakura Y. FIP1L1-PDGFRα imposes eosinophil lineage commitment on hematopoietic stem/progenitor cells. J Biol Chem. 2009;284:7719-32 [PMID:19147501]
○Feng J, Iwama A, Satake M and Kohu K. MicroRNA-27 enhances differentiation of myeloblasts into granulocytes by post-transcriptionally down-regulating Runx1. Br J Haematol. 2009;145(3):412-23.[PMID:19298589]
○Oguro H, Yuan J, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H, Nakauchi H and Iwama A. Poised lineage specification in multipotent hematopoietic stem and progenitor cells by the polycomb protein Bmi1. Cell Stem Cell. 2010;6:279-286. [PMID:20207230]
○Okabe M, Otsu M, Ahn DH, Kobayashi T, Morita Y, Wakiyama Y, Onodera M, Eto K, Ema H and Nakauchi H. Definitive proof for direct reprogramming of hematopoietic cells to pluripotency. Blood 2009; 114:1764-1767.[PMID:19564635]
○Nishino T, Miyaji K, Ishiwata N, Arai K, Yui M, Asai Y, Nakauchi H and Iwama A. Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL. Exp. Hematol. 2009; 37:1364-1377. [PMID:19744539]
○Koizumi T, Negishi M, Oguro H, Satoh K, Ichinose M and Iwama A. Depletion of Dnmt1-associated protein 1 triggers DNA damage and compromises the proliferative capacity of hematopoietic stem cells. Int J Hematol. 2010;91(4):611-619. [PMID:20387133]
○Yuan J, Takeuchi M, Negishi M, Oguro H, Ichikawa H and Iwama A. Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells. Leukemia. 2011;25:1335-1343. [PMID:21527932]
○Konuma T, Nakamura S, Miyagi S, Negishi M, Chiba T, Oguro H, Yuan J, Mochizuki-Kashio M, Ichikawa H, Miyoshi H, Vidal M and Iwama A. Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells. Exp. Hematol. 2011;39:697-709. [PMID:21527932]
○Oshima M, Endoh M, Endo TA, Toyoda T, Nakajima-Takagi Y, Sugiyama F, Koseki H, Iwama A and Osawa M. Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells. Blood. 2011;vol.117;no.15;e142-e150. [PMID:21343615]
○Negishi M, Saraya A, Mochizuki S, Helin K, Koseki H and Iwama A. A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/Arf locus through polycomb repressive complex 1. PLoS One 2010;5:e12373. [PMID:20808772]
○Sugawara T, Oguro H, Negishi M, Morita Y, Ichikawa H, Iseki T, Yokosuka O, Nakauchi H and Iwama A. FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells. Exp. Hematol. 2010; 38: 696-706. [PMID:20412831]
○Hayashi Y, Chan T, Warashina M, Fukuda M, Ariizumi T, Okabayashi K, Takayama N, Otsu M, Eto K, Furue MK, Michiue T, Ohnuma K, Nakauchi H and Asashima M. Reduction of N-glycolylneuraminic acid in human induced pluripotent stem cells generated or cultured under feeder- and serum-free defined conditions. PLoS One. 2010;5:e14099. [PMID:21124894]
○Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H and Eto K. Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. J. Exp. Med. 2010;7:2817-2830. [PMID:21059868]
○Li X, Isono K, Yamada D, Endo TA, Endoh M, Shinga J, Mizutani-Koseki Y, Otte AP, Casanova M, Kitamura H, Kamijo T, Sharif J, Ohara O, Toyada T, Bernstein BE, Brockdorff N and Koseki H. Mammalian Polycomb-Like Pcl2/Mtf2 Is a Novel Regulatory Component of PRC2 That Can Differentially Modulate Polycomb Activity both at the Hox Gene Cluster and at Cdkn2a Genes. Mol. Cell. Biol. 2011;31:351-364.[PMID:21098095]
○Oguro H, Yuan J, Tanaka S, Miyagi S, Mochizuki-Kashio M, Ichikawa H, Yamazaki S, Koseki H, Nakauchi H and Iwama A. Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes. J. Exp. Med. 2012;209:445-454.[PMID:22351929]
○Mochizuki-Kashio M, Mishima Y, Miyagi S, Negishi M, Saraya A, Konuma T, Shinga J, Koseki H and Iwama A. Dependency on the polycomb protein Ezh2 distinguishes fetal from adult hematopoietic stem cells. Blood. 2011;118:6553-6561.[PMID:22042701]
○Mishima Y, Miyagi S, Saraya A, Negishi M, Endoh M, Endo TA, Toyoda T, Shinga J, Katsumoto T, Chiba T, Yamaguchi N, Kitabayashi I, Koseki H and Iwama A. The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis. Blood. 2011;118:2443-2453.[PMID:21753189]
○Umemoto T, Yamato M, Ishihara J, Shiratsuchi Y, Utsumi M, Morita Y, Tsukui H, Terasawa M, Shibata T, Nishida K, Kobayashi Y, Petrich BG, Nakauchi H, Eto K and Okano T. Integrin αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells. Blood. 2012;119:83-94.[PMID:22096247]

奥田チーム
○Zhang J, Nomura J, Maruyama M, Nishimoto M, Muramtsu M, and Okuda A. Identification of an ES cell pluripotent state-specifci DUSP6 enhancer. Biochem. Biophys. Res. Commun. 2009;378:319-323 [PMID:19032937]
○Nomura J, Maruyama M, Katano M, Kato H, Zhang J, Masui S, Mizuno Y, Okazaki Y, Nishimoto M and Okuda A. Differential requirement of Nucleostemin in embryonic stem cell and neural stem cell viability. Stem Cells. 2009;27:1066-1076 [PMID:19418458]
○Suzuki K, Ohbayashi F, Nikaido I, Okuda A, Takaki H, Okazaki Y and Mitani K. Integration of exogenous DNA into mouse embryonic stem cell chromosome shows preference into genes and frequent modification at junctions. Chromosome Res. 2010;18(2);191-201. [PMID:20177773]
○Hishida T, Nozaki Y, Nakachi Y, Mizuno Y, Okazaki Y, Ema M, Takahashi S, Nishimoto M, Okuda A. Indefinite Self-Renewal of ES Cells through Myc/Max Transcriptional Complex-Independent Mechanisms. Cell Stem Cell. 2011;9;37-49. [PMID:21726832]
○Mariani J, Favaro R, Lancini C, Vaccari G, Ferri AL, Bertolini J, Tonoli D, Latorre E, Caccia R, Ronchi A, Ottolenghi S, Miyagi S, Okuda A, Zappavigna V and Nicolis SK. Emx2 is a dose-dependent negative regulator of Sox2 telencephalic enhancers. Nucleic Acids Res. 2012 Apr 11. [Epub ahead of print] [PMID:22495934]

押村チーム
○Yang KC, Wu CC, Lin FH, Qi Z, Kou TF, Cheng YH, Chen MP and Sumi S. Chitosan/gelatin hydrogel as immunoisolative matrix for injectable bioartificial pancreas. Xenotransplantation. 2008;15:407-416 [PMID:19152669]
○Kazuki Y, Hiratsuka M, Takiguchi M, Osaki M, Kajitani N, Hoshiya H, Hiramatsu K, Yoshino T, Kazuki K, Ishihara C, Takehara S, Higaki K, Nakagawa M, Takahashi K, Yamanaka S and Oshimura M. Complete genetic correction of iPS cells from Duchenne muscular dystrophy. Mol.Therapy. 2009;18:238-240 [PMID:19997091]
○Katoh M, Kazuki Y, Kazuki K, Kajitani N, Takiguchi M, Nakayama Y, Nakamura T and Oshimura M. Exploitation of the interaction of measles virus fusogenic envelope proteins with the surface receptor CD46 on human cells for microcell-mediated chromosome transfer. BMC Biotechnol. 2010;10:37. [PMID:20444293]
○Iida Y, Kim JH, Kazuki Y, Hoshiya H, Takiguchi M, Hayashi M, Erliandri I, Lee HS, Samoshkin A, Masumoto H, Earnshaw WC, Kouprina N, Larionov V and Oshimura M. Human Artificial Chromosome with a Conditional Centromere for Gene Delivery and Gene Expression. DNA Res. 2010;17:293-301. [PMID:20798231]
○Kazuki Y, Hoshiya H, Takiguchi M, Abe S, Iida Y, Osaki M, Katoh M, Hiratsuka M, Shirayoshi Y, Hiramatsu K, Ueno E, Kajitani N, Yoshino T, Kazuki K, Ishihara C, Takehara S, Tsuji S, Ejima F, Toyoda A, Sakaki Y, Larionov V, Kouprina N and Oshimura M. Refined human artificial chromosome vectors for gene therapy and animal transgenesis. Gene Therapy. 2010;18(4):384-93. [PMID:21085194]
○Yamaguchi S, Kazuki Y, Nakayama Y, Nanba E, Oshimura M and Ohbayashi T. A method for producing transgenic cells using a multi-integrase system on a human artificial chromosome vector. PLoS One. 2011;24:e17267. [PMID:21390305]
○Qi Z, Yamamoto C, Imori N, Kinukawa A, Yang KC, Yanai G, Ikenoue E, Shen Y, Shirouzu Y, Hiura A, Inoue K and Sumi S. Immunoisolation effect of polyvinyl alcohol (PVA) macro-encapsulated islets in type 1 diabetes therapy. Organ Biology. 2009;16:162.
○Qi Z, Shen Y, Yanai G, Yang K, Shirouzu Y, Hiura A and Sumi S. The in vivo performance of polyvinyl alcohol macro-encapsulated islets. Biomaterials. 2010;31:4026-4031. [PMID:20149430]
○Yang KC, Qi Z, Wu CC, Shirouzu Y, Lin FH, Yanai G and Sumi S. The cytoprotection of chitosan based hydrogels in xenogeneic islet transplantation: An in vivo study in streptozotocin-induced diabetic mouse. Biochem Biophys Res Commun. 2010;393:818-823. [PMID:20171166]
○Yang KC, Wu CC, Qi Z, Chen JC, Sumi S and Lin FH. Comparison of bioartificial pancreas performance in the bone marrow cavity and intramuscular space. Archives of Medical Research 2010;41:151-153. [PMID:20682171]
○Yang KC, Wu CC, Sumi S, Tseng CL, Wu YH, Kuo TF and Lin FH. Calcium phosphate cement chamber as an immunoisolative device for bioartificial pancreas: In vitro and preliminary in vivo study. Pancreas 2010;39:444-451. [PMID:20084047]
○Yang KC, Wu CC, Sumi S, Kuo TF, Lin SC and Lin FH. Intramedullary cavity as an implant site for bioartificial pancreas: An in vivo study on diabetic canine. Transplantation. 2010;90:604-611. [PMID:20048693]
○Yang KC, Wu CC, Lin SC, Sumi S and Lin FH. The in vivo performance of bioartificial pancreas in bone marrow cavity: A case report of a spontaneous diabetic feline. Biochem Biophys Res Commun. 2010;393:362-364. [PMID:20043867]
○Tedesco FS, Hoshiya H, D’Antona G, Gerli FM, Messina G, Antonini S, Tonlorenzi R, Benedetti S, Berghella L, Torrente Y, Kazuki H, Bottinelli R, Oshimura M and Cossu G. Stem Cell-Mediated transfer of a Human Artificial Chromosome Containing the Entire Dystrophin Locus Ameliorates Muscular Dystrophy. Sci Transl Med. 2011;3(96):96ra78. [PMID:21849666]
○Kurosaki H, Hiratsuka M, Imaoka N, Iida Y, Uno N, Kazuki Y, Ishihara C, Yakura Y, Mimuro J, Sakata Y, Takeya H and Oshimura M. Integration-free and stable expression of FVIII using a human artificial chromosome. J Hum Genet. 2011;56(10):727-733. [PMID:21833006]
○Hiratsuka M, Uno N, Ueda K, Kurosaki H, Imaoka N, Kazuki K, Ueno E, Akakura Y, Katoh M, Osaki M, Kazuki Y, Nakagawa M, Yamanaka S and Oshimura M. Integration-Free iPS Cells Engineered Using Human Artificial Chromosome Vectors. PLoS One. 2011;6(10):e25961. [PMID:21998730]
○Kim JH, Kononenko A, Erliandri I, Kim TA, Nakano M, Iida Y, Barrett JC, Oshimura M, Masumoto H, Earnshaw WC, Larionov V and Kouprina N. Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells. Proc Natl Acad Sci USA. 2011;108(50):20048-20053. [PMID:22123967]
○Kakeda M, Nagata K, Osawa K, Matsuno H, Hiratsuka M, Sano A, Okazaki A, Shitara S, Nishikawa S, Masuya A, Hata T, Wako S, Osaki M, Kazuki Y, Oshimura M and Tomizuka K. A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells. Biochem Biophys Res Commun. 2011;415(3):439-444. [PMID:22051050]

古関チーム
○Ku M, Koche RP, Rheinbay E, Mendenhall EM, Endoh M, Mikkelsen TS, Presser A, Nusbaum C, Xie X, Chi AS, Adli M, Kasif S, Ptaszek LM, Cowan CA, Lander ES, Koseki H and Bernstein BE. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet. 2008;4:e1000242. [PMID:18974828]
○Schwermann J, Rathinam C, Schubert M, Schumacher S, Noyan F, Koseki H, Kotlyarov A, Klein C and Gaestel M. MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells. EMBO J. 2009;28:1392-1406. [PMID:19369945]
○Roman-Trufero M, Mendez-Gomez HR, Perez C, Hijikata A, Fujimura Y, Endo T, Koseki H, Vicario-Abejon C and Vidal M. Maintenance of undifferentiated state and self-renewal of embryonic neural stem cells by Polycomb protein Ring1B. Stem Cells. 2009;27:1559-1570. [PMID:19544461]
○Watarai H, Rybouchkin A, Hongo N, Nagata Y, Sakata S, Sekine E, Dashtsoodol N, Tashiro T, Fujii SI, Shimizu K, Mori K, Masuda K, Kawamoto H, Koseki H and Taniguchi M. Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Va14-Ja18 TCRa gene. Blood 2009; 14:230-237. [PMID:19897575]
○Saito Y, Uchida N, Tanaka S, Suzuki N, Tomizawa-Murasawa M, Sone A, Najima Y, Takagi S, Aoki Y, Wake A, Taniguchi S, Shultz L.D and Ishikawa F. Cell cycle entry potentiates elimination of quiescent chemotherapy-resistant human AML stem cells. Nature Biotechnology 2010; 28: 275-280.
○Watarai H, Fujii S, Yamada D, Rybouchkin A, Sakata S, Nagata Y, Iida-Kobayashi M, Sekine-Kondo E, Shimizu K, Shozaki Y, Sharif J, Matsuda M, Mochiduki S, Hasegawa T, Kitahara G, Endo TA, Toyoda T, Ohara O, Harigaya K, Koseki H and Taniguchi M. Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells. J Clin Invest. 2010;120:2610-2618. [PMID:20516640]
○Pereira CF, Piccolo FM, Tsubouchi T, Sauer S, Ryan NK, Bruno L, Landeira D, Santos J, Banito A, Gil J, Koseki H, Merkenschlager M and Fisher AG. ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency. Cell Stem Cell. 2010;6:547-556. [PMID:20569692]
○Negishi M, Saraya A, Mochizuki S, Helin K, Koseki H and Iwama A. A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1. PLoS One 2010;5:e12373. [PMID:20808772]
○Li X, Isono KI, Yamada D, Endo TA, Endoh M, Shinga J, Mizutani-Koseki Y, Otte AP, Casanova M, Kitamura H, Kamijo T, Sharif J, Ohara O, Toyada T, Bernstein BE, Brockdorff N and Koseki H. Mammalian Polycomblike Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate Polycomb activity at both the Hox gene cluster and at Cdkn2a genes. Mol Cell Biol. 2011;31(2):351-364. [PMID:21059868]
○Tan J, Jones M, Koseki H, Nakayama M, Muntean AG, Maillard I and Hess JL. CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis. Cancer Cell. 2011;20:563-575. [PMID:22094252]
○Oshima M, Endoh M, Endo TA, Toyoda T,　Nakajima-Takagi Y, Sugiyama F, Koseki H, Kyba M, Iwama A and Osawa M. Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells. Blood. 2011;117:e142-e150. [PMID:21343615]
○Casanova M, Preissner T, Cerase A, Poot R, Yamada D, Li X, Appanah R, Bezstarosti K, Demmers J, Koseki H and Brockdorff N. Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells. Development. 2011;138(8):1471-1482. [PMID:21367819]
○Mochizuki-Kashio M, Mishima Y, Miyagi S, Negishi M, Saraya A, Konuma T, Shinga J, Koseki H and Iwama A. Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells. Blood. 2011;118:6553-6561. [PMID:22042701]
○Hisada K, Sanchez C, Endo T, Endoh M, Roman-Trufero M, Sharif J, Koseki H and Vidal M. RYBP represses endogenous retroviruses, preimplantation- and germline-specific genes in mouse embryonic stem cells. Mol Cell Biol. 2012;32(6):1139-1149. [PMID:22269950]
○Takagi S, Saito Y, Hijikata A, Tanaka S, Watanabe T, Hasegawa T, Mochizuki S, Kunisawa J, Kiyono H, Koseki H, Ohara O, Saito T, Taniguchi S, Shultz LD and Ishikawa F. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood. 2012;119:2768-2777. [PMID:22279057]
○Watarai H, Sekine-Kondo E, Shigeura T, Motomura Y, Yasuda T, Satoh R, Yoshida H, Kubo M, Kawamoto H, Koseki H and Taniguchi M. Development and function of invariant natural killer T cells producing t(h)2- and t(h)17-cytokines. PLoS. Biol. 2012;10:e1001255. [PMID:21367819]

佐谷チーム
○Sampetrean O, Iida S, Makino S, Matsuzaki Y, Ohno K, Saya H. Reversible whole-organism cell cycle arrest in a living vertebrate. Cell Cycle. 2009;8:620-627. [PMID:19182528]
○Kosugi S, Hasebe M, Matsumura N, Takashima H, Miyamoto-Sato E, Tomita M, Yanagawa H. Six classes of nuclear localization signals specific to different binding grooves of importinα. J Biol Chem. 2009;284:478-485. [PMID:19001369]
○Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H and Suda T. M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med. 2009;206:1089-1102. [PMID:19398755]
○Kai K, Nagano O, Sugihara E, Arima Y, Sampetrean O, Ishimoto T, Nakanishi M, Ueno N, Iwase H and Saya H. Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model. Cancer Sci. 2009;100:2275-2282. [PMID:19737148]
○Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T, Baba H, Saya H and Nagano O. CD44+ slow-cycling tumor cell expansion is triggered by the cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis. Cancer Sci. 2010;101:673-378. [PMID:20028388]
○Tamase A, Muraguchi T, Naka K, Tanaka S, Kinoshita M, Hoshii T, Ohmura M, Shugo H, Ooshio T, Nakada M, Sawamoto K, Onodera M, Matsumoto K, Oshima M, Asano M, Saya H, Okano H, Suda T, Hamada J and Hirao A. Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin. Proc Natl Acad Sci USA 2009;106:17163-17168. [PMID:19805150]
○Takahashi E, Nagano O, Ishimoto T, Yae T, Suzuki Y, Shinoda T, Nakamura S, Niwa S, Ikeda S, Koga H, Tanihara H and Saya H. Tumor Necrosis Factor-α Regulates Transforming Growth Factor-β-dependent Epithelial-Mesenchymal Transition by Promoting Hyaluronan-CD44-Moesin Interaction. J Biol Chem. 2010;285:4060-4073. [PMID:19965872]
○Tabata N, Sakuma Y, Honda Y, Doi N, Miyamoto-Sato E and Yanagawa H. Rapid antibody selection by mRNA display on a microfluidic chip. Nucleic Acids Res. 2009;37:e64. [PMID:19336414]
○Sumida T, Doi N and Yanagawa H. Bicistronic DNA display for in vitro selection of Fab fragments. Nucleic Acids Res. 2009;37:e147. [PMID:19789273]
○Matsumura N, Tsuji T, Sumida T, Kokubo M, Onimaru M, Doi N, Takashima H, Miyamoto-Sato E and Yanagawa H. mRNA display selection of a high-affinity, Bcl-XL-specific binding peptide. FASEB J. 2010;24:2201-2210. [PMID:20181936]
○Horisawa K, Imai T, Okano H and Yanagawa H. The Musashi family RNA-binding proteins in stem cells. Biomol. Concepts. 2010;1:59-66
○Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T, Baba H, Saya H and Nagano O. CD44+ slow-cycling tumor cell expansion is triggered by the cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis. Cancer Sci. 2010;101:673-678. [PMID:20028388]
○Miyamoto-Sato E, Ishizaka M, Fujimori S, Hirai N, Masuoka K, Saito R, Ozawa Y, Hino K, Washio T, Tomita M, Yamashita T, Oshikubo T, Akasaka H, Sugiyama J, Matsumoto Y and Yanagawa H. A comprehensive resource of interacting protein regions for refining human transcription factor networks: Domain-based interactome. PLoS One. 2010;5:e9289. [PMID:20195357]
○Shimizu T, Ishikawa T, Sugihara E, Kuninaka S, Miyamoto T, Mabuchi Y, Matsuzaki Y, Tsunoda T, Miya F, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Kawai A, Ichikawa H, Hasegawa T, Okada S, Ito T, Ikeda Y, Suda T and Saya H c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis. Oncogene. 2010;29:5687-5699. [PMID:20676132]
○Ozawa Y, Saito R, Fujimori S, Kashima H, Ishizaka M, Yanagawa H, Miyamoto-Sato E and Tomita M. Protein complex prediction via verifying and reconstructing the topology of domain-domain interactions. BMC Bioinformatics. 2010;11:350. [PMID:20584269]
○Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu JI, Saya H, Hamada JI and Hirao A. NKX2.2 suppresses self renewal of glioma-initiating cells. Cancer Res. 2011;71:1135-45. [PMID:21169405]
○Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, Masuko T, Shimizu T, Ishikawa T, Kai K, Takahashi E, Imamura Y, Baba Y, Ohmura M, Suematsu M, Baba H and Saya H. CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc- and thereby promotes tumor growth. Cancer Cell. 2011;19:387-400. [PMID:21397861]
○Ishizawa J, Kuninaka S, Sugihara E, Naoe H, Kobayashi Y, Chiyoda T, Ueki A, Araki K, Yamamura K, Matsuzaki Y, Nakajima H, Ikeda Y, Okamoto S and Saya H. The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress. Cancer Sci. 2011;102(5):967-974. [PMID:21255192]
○Shiheido H, Takashima H, Doi N and Yanagawa H. mRNA display selection of an optimized MDM2-binding peptide that potently inhibits MDM2-p53 interaction. PLoS One. 2010;6:e17898. [PMID:21423613]
○Sugihara E, Shimizu T, Kojima K, Onishi N, Kai K, Ishizawa J, Nagata K, Hashimoto N, Honda H, Kanno M, Miwa M, Okada S, Andreeff M and Saya H. Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor. Oncogene. 2012;31(23):2849-61. [PMID:21423613]
○Sampetrean O, Saga I, Nakanishi M, Sugihara E, Fukaya R, Onishi N, Osuka A, Akahata M, Kai K, Sugimoto H, Hirao A and Saya H. Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells. Neoplasia. 2011;13:784-791. [PMID:21969812]
○Motohara T, Masuko S, Ishimoto T, Yae T, Onishi N, Muraguchi T, Hirao A, Matsuzaki Y, Tashiro H, Katabuchi H, Saya H and Nagano O. Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells. Carcinogenesis. 2011;32:1597-1606. [PMID:21828057]
○Shimizu T, Ishikawa T, Iwai S, Ueki A, Sugihara E, Onishi N, Kuninaka S, Miyamoto T, Toyama Y, Ijiri H, Mori H, Matsuzaki Y, Yaguchi T, Nishio H, Kawakami Y, Ikeda Y and Saya H. Fibroblast growth factor-2 (Fgf2) is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma. Mol. Cancer Res. 2012;10:454-468. [PMID:22228819]
○Kobayashi Y, Shimizu T, Naoe H, Ueki A, Ishizawa J, Chiyoda T, Onishi N, Sugihara E, Nagano O, Banno K, Kuninaka S, Aoki D and Saya H. Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV12. Am. J. Pathol. 2011;79:1471-1482. [PMID:21787741]
○Masuko K, Okazaki S, Satoh M, Tanaka G, Ikeda T, Torii R, Ueda E, Nakano T, Danbayashi M, Tsuruoka T, Ohno Y, Yagi H, Yabe N, Yoshida H, Tahara T, Kataoka S, Oshino T, Shindo T, Niwa S, Ishimoto T, Baba H, Hashimoto Y, Saya H and Masuko T. Anti-tumor effect against human cancer xenografts by a fully human monoclonal antibody to a variant 8-epitope of CD44R1 expressed on cancer stem cells. PLoS One. 2012;7:e29728. [PMID:22272243]
○Tamada M, Nagano O, Tateyama S, Ohmura M, Yae T, Ishimoto T, Sugihara E, Onishi N, Yamamoto T, Yanagawa H, Suematsu M and Saya H. Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells. Cancer Res. 2012;72:1438-1448. [PMID:22293754]
○Doi N, Yamakawa N, Matsumoto N, Yamamoto Y, Nagano T, Matsumura N, Horisawa K and Yanagawa H. DNA display selection of peptide ligands for a full-length human G protein-coupled receptor on CHO-K1 cells. PLoS One. 2012;7:e30084. [PMID:22272243]
○Shiheido H, Terada F, Tabata N, Hayakawa I, Matsumura N, Takashima H, Ogawa Y, Du W, Yamada T, Shoji M, Sugai T, Doi N, Iijima S, Hattori Y and Yanagawa H. A Phthalimide Derivative that Inhibits Centrosomal Clustering is Effective on Multiple Myeloma. PLoS One. 2012;7:e38878 [PMID:22761710]

篠原チーム
○Lee J, Kanatsu-Shinohara M, Ogonuki N, Miki H, Inoue K, Morimoto T, Morimoto H, Ogura A and Shinohara T. Heritable imprinting defect caused by epigenetic abnormalities in mouse spermatogonial stem cells. Biol Reprod. 2009;80:518-527. [PMID:19020300]
○Kanatsu-Shinohara M, Takehashi M, Takashima S, Lee J, Chuma S, Nakatsuji N, Fassler R and Shinohara T. Homing of mouse spermatogonial stem cells to germline niche depends on β1-integrin. Cell Stem Cell. 2008;3:533-542. [PMID:18983968]
○Kanatsu-Shinohara M, Kato M, Takehashi M, Morimoto H, Takashima S, Chuma S, Nakatsuji N, Hirabayashi M and Shinohara T. Production of transgenic rats via lentiviral and xenogeneic transplantation of spermatogonial stem cells. Biol.Reprod. 2008;79:1122-28. [PMID:18685123]
○Takashima S, Takehashi M, Lee J, Chuma S, Okano M, Hata K, Suetake I, Nakatsuji N, Miyoshi H, Tajima S, Sasaki H, Kanatsu-Shinohara M and Shinohara T. Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects. Biol. Reprod. 2009;81:155-164. [PMID:19228594]
○Lee J, Kanatsu-Shinohara M, Morimoto H, Kazuki Y, Takashima S, Oshimura M, Toyokuni S and Shinohara T. Genetic reconstruction of mouse spermatogonial stem cell self-renewal in vitro by Ras-cyclin D2 activation. Cell Stem Cell. 2009;5:76-86. [PMID:19570516]
○Morimoto H, Kanatsu-Shinohara M, Takashima S, Chuma S, Nakatsuji N, Takehashi M and Shinohara T. Phenotypic plasticity of mouse spermatogonial stem cells. Plos One. 2009;4:e7909. [PMID:19936070]
○Kanatsu-Shinohara M, Ogonuki N, Miki H, Inoue K, Morimoto H, Takashima S, Ogura A and Shinohara T. Genetic influences in mouse spermatogonial stem cell self-renewal. J. Reprod. Dev. 2010;56:145-153 [PMID:19926938]
○Takehashi M, Kanatsu-Shinohara M and Shinohara T. Generation of genetically modified animals using spermatogonial stem cells. Dev Growth Differ 2010;52(3):303-310. [PMID:20148923]
○Kanatsu-Shinohara M, Takashima S and Shinohara T. Transmission distortion caused by loss of p21 or p27 cyclin-dependent kinase inhibitors following competitive spermatogonial transplantation. Proc Natl Acad Sci USA 2010;107(14):6210-6215. [PMID:20308578]
○Iwasa T, Baba S, Doi H, Kaichi S, Yokoo N, Mima T, Kanatsu-Shinohara M, Shinohara T, Nakahata T and Heike T. Neonatal mouse testis-derived multipotent germline stem cells improve the cardiac function of acute ischemic heart mouse model. Biochem Biophys Res Commun 2010;400(1):27-33. [PMID:20691159]
○Kanatsu-Shinohara M, Inoue K, Ogonuki N, Morimoto H, Ogura A and Shinohara T. Serum- and feeder-free culture of mouse germline stem cells. Biol. Reprod. 2011;84(1):97-105. [PMID:20844279]
○Kanatsu-Shinohara M, Kato-Itoh M, Ikawa M, Takehashi M, Sanbo M, Morioka Y, Tanaka T, Morimoto H, Hirabayashi M and Shinohara T. Homologous recombination in rat germline stem cells. Biol.Reprod. 2011;85(1):208-217. [PMID:21471297]
○Kanatsu-Shinohara M, Takashima S and Shinohara T. Dynamic changes in EPCAM expression during spermatogonial stem cell differentiation in the mouse testis. PLoS One. 2011;6:e23663. [PMID:21858196]
○Takashima S, Kanatsu-Shinohara M, Tanakai T, Takehashi M, Morimoto H and Shinohara T. Rac mediates mouse spermatogonial stem cell homing to germline niches by regulating transmigration through the blood-testis barrier. Cell Stem Cell 2011;5:463-475. [PMID:22056142]
○Morimoto H., Lee J., Tanaka T., Ishii K., Toyokuni S., Kanatsu-Shinohara M. and Shinohara T. In vitro transformation of mouse testis cells by oncogene transfection. Biol Reprod. 2012;86(5):148. [PMID:22357549]

千住チーム
○Matsunaga Y, Fukuma D, Hirata H, Fukushima S, Haruta M, Ikeda T, Negishi I, Nishimura Y and Senju S. Activation of antigen-specific cytotoxic T lymphocytes by b2-microglobulin or TAP1 gene disruption and the introduction of recipient-matched MHC class I gene in allogeneic ES cell-derived dendritic cells. J Immunol. 2008;181:6635-43. [PMID:18941254]
○Fukushima S, Hirata S, Motomura Y, Fukuma D, Matsunaga Y, Ikuta Y, Ikeda T, Kageshita T, Ihn H, Nishimura Y and Senju, S. Multiple antigen-targeted immunotherapy with a-galactosylceramide-loaded and genetically engineered dendritic cells derived from embryonic stem cells. J Immunother. 2009;32(3):219-31. [PMID:19242378]
○Senju S, Haruta M, Matsunaga Y, Fukushima S, Ikeda T, Takahashi K, Okita K, Yamanaka S and Nishimura Y. Characterization of dendritic cells and macrophages generated by directed differentiation from mouse induced pluripotent stem cells. Stem Cells. 2009; 27:1021-1031. [PMID:19415766]
○Inoue M, Senju S, Hirata S, Irie A, Baba H and Nishimura Y. An in vivo model of priming of antigen-specific human CTL by Mo-DC in NOD/Shi-scid IL2rγnull (NOG) mice. Immunol. Lts. 2009;126: 67-72. [PMID:19682495]
○Ikeda T, Hirata S, Fukushima S, Matsunaga Y, Ito T, Uchino M, Nishimura Y and Senju S. Dual effects of TRAIL in suppression of autoimmunity: the inhibition of Th1 cells and the promotion of regulatory T cells. J Immunol. 2010;185(9):5259-5267. [PMID:20921531]
○Senju S, Haruta M, Matsumura K, Matsunaga Y, Fukushima S, Ikeda T, Takamatsu K, Irie A and Nishimura Y. Generation of dendritic cells and macrophages from human induced pluripotent stem cells aiming at cell therapy. Gene Ther. 2011;18:847-883. [PMID:21430784]

丹羽チーム
○Aiba K, Nedorezov T, Piao Y, Nishiyama A, Matoba R, Sharova LV, Sharov AA, Yamanaka S, Niwa H and KO MS. Defining developmental potency and cell lineage trajectories by expression profiling of differentiating mouse embryonic stem cells. DNA Res. 2009;16:73-80. [PMID:19112179]
○Nishioka N, Inoue K, Adachi K, Kiyonari H, Ota M, Ralston A, Yabuta N, Hirahara H, Stephenson RO, Ogoniki N, Makita R, Kurihara H, Morin-Kensicki EM, Nojima H, Rossant J, Nakao K, Niwa H and Sasaki H. The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev. Cell. 2009;16:398-410. [PMID:19289085]
○Yuri S, Fujimura S, Nimura K, Takeda N, Toyooka Y, Fujimura Y, Aburatani H, Ura K, Koseki H, Niwa H and Nishinakamura R. Sall4 is essential for stabilization, but not for pluripotency of embryonic stem cells by repressing aberrant trophectoderm gene expression. Stem Cells. 2009;27:796-805. [PMID:19350679]
○Niwa H, Ogawa K, Shimosato D and Adachi K. A parallel circuit of LIF signaling pathways maintains pluripotency of mouse ES cells. Nature. 2009;460:118-122. [PMID:19571885]
○Sun C, Nakatake Y, Akagi T, Ura H, Matsuda T, Nishiyama A, Koide H, Ko MSH, Niwa H and Yokota T. Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells. Mol. Cell. Biol. 2009;29:4574-4583. [PMID:19528230]
○Kitajima H and Niwa H. Clonal expansion of human pluripotent stem cells on gelatin-coated surface. Biochem Biophys Res Commun. 2010;396:933-938. [PMID:20460107]
○Murakami K, Araki K, Ohtsuka S, Wakayama T and Niwa H. Choice of random rather than imprinted X inactivation in female ES cell-derived extra-embryonic cells. Development 2011;138;197-202. [PMID:21148183]
○Hirota T, Ohta H, Shigeta M, Niwa H and Saitou M. Drug-inducible gene recombination by the Dppa3-MER Cre MER transgene in the developmentalcycle of the germ cell lineage in mice. Biol.Reprod. 2011;85(2);367-377. [PMID:21525417]
○Ura H, Murakami K, Akagi T, Kinoshita K, Yamaguchi S, Masui S, Niwa H, Koide H and Yokota T. Eed/Sox2 regulatory loop controls ES cell self-renewal through histone methylation and acetylation. EMBO J. 2011;30(11);2190-2204. [PMID:21540835]

米田チーム
○Kim JH, Ebersole T, Kouprina N, Noskov VN, Ohzeki J, Masumoto H, Mravinac B, Sullivan BA, Pavlicek A, Dovat S, Pack SD, Kwon YW, Flanagan PT, Loukinov D, Lobanenkov V and Larionov V. Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing. Genome Res. 2009;19,533-544. [PMID:19141594]
○Cardinale S, Bergmann JH, Kelly D, Nakano M, Valdivia MM, Kimura H, Masumoto H, Larionov V and Earnshaw WC. Hierarchical inactivation of a synthetic human kinetochore by chromatin modifiers. Mol. Biol. Cell. 2009;20:4194-4204. [PMID:19656847]
○Mehmood R, Yasuhara N, Oe S, Nagai M and Yoneda Y. Synergistic nuclear import of NeuroD1 and its partner transcription factor, E47, via heterodimerization. Exp. Cell Res. 2009;315:1639-1652. [PMID:19272376]
○Ogawa Y, Miyamoto Y, Asally M, Oka M, Yasuda Y and Yoneda Y. Two isoforms of Npap60 (Nup50) differentially regulate nuclear protein import. Mol. Biol. Cell. 2010;21:630-638. [PMID:20016008]
○Iida Y, Kim JH, Kazuki Y, Hoshiya H, Takiguchi M, Hayashi M, Erliandri I, Lee HS, Samoshkin A, Masumoto H, Earnshaw WC, Kouprina N, Larionov V and Oshimura M. Human Artificial Chromosome with a Conditional Centromere for Gene Delivery and Gene Expression. DNA Res. 2010;17:293-301. [PMID:20798231]
○Bergmann JH, Gomez M, Martins NMC, Kimura H, Kelly DA, Masumoto H, Larionov V, Jansen LET and Earnshaw WC. Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore. EMBO J. 2011;30:328-340. [PMID:21157429]
○Okada M, Oka M and Yoneda Y. Effective culture conditions for the induction of pluripotent stem cells. Biochim Biophys Acta. 2010;1800:956-963. [PMID:20417254]
○Okada M and Yoneda Y. The timing of retroviral silencing correlates with the quality of induced pluripotent stem cell lines. Biochim Biophys Acta. 2011;1810:226-235. [PMID:20965232]
○Oka M, Asally M, Yasuda Y, Ogawa Y, Tachibana T and Yoneda Y. The mobile FG nucleoporin Nup98 is a cofactor for Crm1-dependent protein export. Mol Biol Cell. 2010;21:1885-1896. [PMID:20375145]
○Asally M, Yasuda Y, Oka M, Otsuka S, Yoshimura S, Takeyasu K and Yoneda Y. NUP358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis. FEBS J. 2010;278:610-621. [PMID:21205196]
○Nagai M, Moriyama T, Mehmood R, Tokuhiro K, Ikawa M, Okabe M, Tanaka H and Yoneda Y. Mice lacking Ran Binding Protein 1 are viable and show male infertility. FEBS Lett. 2011;585:791-796. [PMID:21310149]
○Moriyama T, Nagai M, Oka M, Ikawa M, Okabe M and Yoneda Y. Targeted disruption of one of the importin αfamily members leads to female functional incompetence in delivery. FEBS J. 2011;278:1561-1572. [PMID:21371262]
○Sekimoto T, Miyamoto Y, Arai S and Yoneda Y. Importin αprotein acts as a negative regulator for Snail protein nuclear import. J. Biol. Chem. 2011;286:15126-15131. [PMID:21454664]
○Kamikawa Y, Yasuhara N and Yoneda Y. Cell type-specific transcriptional regulation of the gene encoding importin-α1. Exp. Cell Res. 2011;317:1970-1978. [PMID:21664354]
○Mehmood R, Yasuhara N, Fukumoto M, Oe S, Tachinbana T and Yoneda Y. Cross talk between distinct nuclear import pathways enables efficient nuclear import of E47 in conjunction with its partner transcription factors. Mol. Biol. Cell. 2011;22:3715-3724. [PMID:21832153]
○Yasuda Y, Miyamoto Y, Yamashiro T, Asally M, Masui A, Loveland KL and Yoneda Y. Nuclear retention of importin αcoordinates cell fate through changes in gene expression. EMBO J. 2011;31:83-94. [PMID:21964068]
○Kim JH, Kononenko A, Erliandri I, Kim T, Nakano M, Iida Y, Barrett CJ, Oshimura M, Masumoto M, Earnshaw WC, Larionov V and Kouprina N. Human Artificial Chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells. Proc. Natl. Acad. Sci. USA. 2011;108:20048-20053. [PMID:22123967]
○Ohzeki J, Bergmann JH, Kouprina N, Noskov V, Nakano M, Kimura H, Earnshaw WC, Larionov V and Masumoto H. Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly. EMBO J. 2012; in press [PMID:22473132]
○Ogawa Y, Miyamoto Y, Oka, M and Yoneda Y. The interaction between importin-alpha and Nup153 promotes importin-alpha/beta-mediated nuclear import. Traffic. 2012; in press [PMID:22510057]

井上チーム
○Inoue H and Yamanaka S. 　　　　　　　　　　　　　　　　　　　　　The Use of Induced Pluripotent Stem Cells in Drug Development. 　　　　　　　　　　　　　　　　　　　　　Clin. Pharmacol. Ther. 2011;89:655-661. [PMID:22241837]
○Yahata N, Asai M, Kitaoka S, Takahashi K., Asaka I, Hioki H, Kaneko T, Maruyama K, Saido T.C, Nakahata T, Asada T, Yamanaka S, Iwata N and Inoue H. Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease. PLoS One. 2011;6(9):e25788. [PMID:21984949]
○Maeda J, Zhang MR, Okauchi T, Ji B, Ono M, Hattori S, Kumata K, Iwata N, Saido TC, Trojanowski JQ, Lee VMY, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, Suhara T, Higuchi M. In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. J Neurosci. 2011;31(12):4720-30. [PMID:21430171]
○Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T, Hamza T, Hardy JA, Heutink P, Hill-Burns EM, Klein C, Latourelle JC, Maraganore DM, Martin ER, Martinez M, Myers RH, Nalls MA, Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Singleton AB, Stefansson K, Toda T, Tung JY, Vance J, Wood NW, Zabetian CP; 23andMe Genetic Epidemiology of Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium; Parkinson's Disease GWAS Consortium; Wellcome Trust Case Control Consortium 2), Young P, Tanzi RE, Khoury MJ, Zipp F, Lehrach H, Ioannidis JP, Bertram L. Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet. 2012;8(3):e1002548. [PMID:22438815]
○Wada T, Goparaju SK, Tooi N, Inoue H, Takahashi R, Nakatsuji N and Aiba K. Amyotrophic lateral sclerosis model derived from human embryonic stem cells overexpressing mutant SOD1. Stem Cells Translational Medicine. 2012;6(9):e25788.

江良チーム
○Aoki H, Hara A, Era T, Kunisada T and Yamada Y. 　　　　　　　　　　　　　　　　　　　　　Genetic ablation of Rest leads to in vitro-specific derepression of neuronal genes during neurogenesis. 　　　　　　　　　　　　　　　　　　　　　Development. 2012;139:667-677. [PMID:22241837]
○Hirosue A, Ishihara K, Tokunaga K, Watanabe T, Saitoh N, Chandra T, Narita M, Shinohara M and Nakao M. Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells. Aging Cell. 2010;20:470-477. [PMID:22340434]

斎藤チーム
○Yamaji M, Tanaka T, Shigeta M, Chuma S, Saga Y and Saitou, M. Functional reconstruction of Nanos3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of Nanos3. Reproduction. 2010;139:381-393. [PMID:19861488]
○Yabuta Y, Ohta H, Abe T, Kurimoro K, Chuma S and Saitou M. TDRD5 is required for retrotransposon silencing, chromatoid body assembly and spermiogenesis in mice. J. Cell Biol. 2011;192:781-795.[PMID:21383078]
○Hayashi K, Ohta H, Kurimoto K, Aramaki S and Saitou M. Genetic reconstruction of mouse spermatogonial stem cell self-renewal in vitro by Ras-cyclin D2 activation. Cell. 2011;146:519-532. [PMID:19570516]
○Hirota T, Ohta H, Shigeta M, Niwa H and Saitou, M. Drug-inducible gene recombination by the Dppa3-MER Cre MER transgene in the developmental cycle of the germ cell lineage in mice. Biol.Reprod. 2011;85:367-377.[PMID:21525417]

高倉チーム
○Naito H, Kidoya H, Sakimoto S, Wakabayashi T and Takakura N. 　　　　　　　　　　　　　　　　　　　　　Identification and characterization of a resident vascular stem/progenitor cell population in preexisting blood vessels. 　　　　　　　　　　　　　　　　　　　　　EMBO J. 2011;31:842-855[PMID:22179698]
○Naito H, Takara K, Wakabayashi T, Kawahara H, Kidoya H, Takakura N. Changes in blood vessel maturation in the fibrous cap of the tumor rim. Cancer Sci. 2012103(3):433-8. [PMID:22098620]
○Yamakawa D, Kidoya H, Sakimoto S, Jia W, Takakura N. 2-Methoxycinnamaldehyde inhibits tumor angiogenesis by suppressing Tie2 activation. Biochem Biophys Res Commun. 2011;415(1):174-80. [PMID:22033407]
○Sakimoto S, Kidoya H, Naito H, Kamei M, Sakaguchi H, Goda N, Fukamizu A, Nishida K and Takakura N. A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice. Development. in press. 2012;139:1327-1335.[PMID:22357924]
○Muramatsu F, Kidoya H, Naito H, Sakimoto S and Takakura N. microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin. Oncogene. in press. [PMID:22391569]

高橋チーム
○Yoshida A, Yamaguchi Y, Nonomura K, Kawakami K, Takahashi Y, Miura M. Simultaneous expression of different transgenes in neurons and glia by combining in utero electroporation with the Tol2 transposon-mediated gene transfer system. Genes Cells 2010;15(5):501-512. [PMID:0384787]
○Hou X, Omi M, Harada H, Ishii S, Takahashi Y and Nakamura H. Conditional knockdown of target gene expression by tetracycline regulated transcription of double strand RNA. Dev. Growth Differ. 2011;53(1):69-75. [PMID:21261612]
○Wang H, Bonnet A, Delfini M, Kawakami K, Takahashi Y and Duprez D. Stable, Conditional, and Muscle-Fiber-Specific Expression of Electroporated Transgenes in Chick Limb Muscle Cells. Dev. Dyn. 2011;240(5):1223-1232. [PMID:21509896]
○Yoshino T, Saito D, Tadokoro R and Takahashi Y. In vivo gene manipulations of epithelial cell sheets: a novel model to study epithelial-to-mesenchymal transition. Dev. Growth Differ. 2011;53:378-388. [PMID:21492151]
○Yokota Y, Saito D, Tadokoro Y and Takahashi Y. Genomically integrated transgenes are stably and conditionally expressed in neural crest cell-specific lineages. Dev. Biol. 2011;353(2):382-395. [PMID:21310145]
○Shimokita E and Takahashi Y. Secondary neurulation: fate-mapping and gene manipulation of the neural tube in tail bud. Dev. Growth Differ. 2011;53(3):401-410. [PMID:21492152]
○Binder BJ, Landman KA, Donald F, Newgreen DF, Simkin JE, Takahashi Y and Zhang D. Spatial Analysis of Multi-species Exclusion Processes: Application to Neural Crest Cell Migration in the Embryonic Gut. Bull. Math. Biol. 2012;74(2):474-490. [PMID:22108739]
○Adameyko I, Lallemend F, Furlan A, Zinin N, Aranda S, Kitambi SS, Blanchart A, Favaro R, Nicolis S, Lubke M. Muller T, Birchmeier C, Suter U, Zaitoun I, Takahashi Y and Ernfors P. Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest. Development. 2012;139(2):397-410. [PMID:22186729]
○Yamada Y, Aoki H, Kunisada T and Hara A. Rest promotes the early differentiation of mouse ESCs but is not required for their maintenance. Cell Stem Cell. 2010;8:10-15. [PMID:20085738]
○Tamaoki N, Takahashi K, Tanaka T, Ichisaka T, Takeda-Kawaguchi T, Iida T, Kunisada T, Shibata T, Yamanaka S and Tezuka K. Dental Pulp Stem Cells as Source for iPS Cell Banks. J. Dent. Res, 2010;89(8):773-778. [PMID:20554890]
○Hara A, Taguchi A, Aoki H, Hatano Y, Niwa M, Yamada Y and Kunisada T. Folate antagonist, methotrexate induces neuronal differentiation of human embryonic stem cells transplanted into nude mouse retina. Neurosci Lett. 2010;477:138-143. [PMID:20434522]
○Iida K, Takeda-Kawaguchi T, Tezuka Y, Kunisada T, Shibata, T and Tezuka K. Hypoxia enhances colony formation and proliferation but inhibits differentiation of human dental pulp cells. Arch Oral Biol. 2010;55:648-654. [PMID:20630496]
○Aoki H, Hara A, Motohashi T, Osawa M, Kunisada T. Functionally distinct melanocyte populations revealed by reconstitution of hair follicles in mice. Pigment Cell Melanoma Res. 2011;24:125-135. [PMID:21054816]
○Walker GJ, Soyer HP, Handoko HY, Ferguson B, Kunisada T, Khosrotehrani K, Box NF, Muller HK. Superficial Spreading-Like Melanoma in Arf(-/-)::Tyr-Nras(Q61K)::K14-Kitl Mice: Keratinocyte Kit Ligand Expression Sufficient to "Translocate" Melanomas from Dermis to Epidermis. J. Invest. Dermatol. 2011;131(6):1384-7. [PMID:21307875]
○Okita K, Matsumura Y, Sato Y, Okada A, Morizane A, Okamoto S, Hong H, K, Nakagawa M, Tanabe K, Tezuka K, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji H and Yamanaka S. A more efficient method to generate integration-free human iPS cells. Nat. Methods. 2011;8:409-412. [PMID:21460823]
○Motohashi T, Yamanaka K, Chiba K, Miyajima K, Aoki H, Hirobe T and Kunisada T. Neural crest cells retain their capability for multipotential differentiation even after lineage-restricted stages. Dev. Dyn. 2011;240:1681-1693. [PMID:21594952]
○Aoki H, Hara A, Motohashi T and Kunisada T. Protective effect of Kit signaling for melanocyte stem cells against radiation-induced genotoxic stress. J. Invest. Dermatol. 2011;131:1906-1915. [PMID:21633369]
○Aoki H, Hara, A, Era,T, Kunisada T and Yamada Y. Genetic ablation of Rest leads to in vitro-specific derepression of neuronal genes during neurogenesis. Development. 2012;139:667-677. [PMID:22241837]
○Kurokawa D, Ohmura T, Ogino H, Takeuchi M, Inoue A, Inoue F, Suda Y and Aizawa S. Evolutionary origin of the Otx2 enhancer for its expression in visceral endoderm. Dev. Biol. 2010;342:110-120. [PMID:20353765]
○Hellsten U, Harland RM, Gilchrist MJ, Hendrix D, Jurka J, Kapitonov V, Ovcharenko I, Putnam NH, Shu S, Taher L, Blitz IL, Blumberg B, Dichmann DS, Dubchak I, Amaya E, Detter JC, Fletcher R, Gerhard DS, Goodstein D, Graves T, Grigoriev IV, Grimwood J, Kawashima T, Lindquist E, Lucas SM, Mead PE, Mitros T, Ogino H, Ohta Y, Poliakov AV, Pollet N, Robert J, Salamov A, Sater AK, Schmutz J, Terry A, Vize PD, Warren WC, Wells D, Wills A, Wilson RK, Zimmerman LB, Zorn AM, Grainger R, Grammer T, Khokha MK, Richardson PM and Rokhsar DS. The genome of the western clawed frog Xenopus tropicalis. Science. 2010;328:633-636. [PMID:20431018]
○Sato S, Ikeda K, Shioi G, Ochi H, Ogino H, Yajima H and Kawakami K. Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR. Dev. Biol. 2010;344:158-171. [PMID:20471971]
○Yokoyama Y, Maruoka T, Ochi H, Aruga A, Ohgo S, Ogino H and Tamura K. Different requirement for Wnt/β-catenin signaling in limb regeneration of larval and adult Xenopus. PLoS One. 2011;6(7):e21721 [PMID:21814549]
○Kawaguchi A, Ochi H, Sudou N and Ogino, H. Comparative expression analysis of the H3K27 demethylases, JMJD3 and UTX, with the H3K27 methylase, EZH2, in Xenopus. Int. J. Dev. Biol. 2012;in press
○Sudou N, Yamamoto S, Ogino H and Taira M. Dynamic in vivo binding of transcription factors to cis-regulatory modules of cer and gsc in the stepwise formation of the Spemann-Mangold organizer. Development. 2012;in press
○Yasunaga K, Kanamori T, Morikawa R, Suzuki E and Emoto K. Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase- mediated modification of the basement membranes. Developmental Cell 2010;18:621-632. [PMID:20412776]
○Fang X, Lu Q, Emoto K and Adler PN. The Drosophila Furry protein interacts with Trc and is highly mobile in vivo. BMC Dev. Biol. 2010;10:40. [PMID:20406475]
○Morikawa R, Kanamori T, Yasunaga K and Emoto K. Different levels of the TRIM protein Asap regulate distinct axonal projections of Drosophila sensory neurons. Proc. Natl. Acad. Sci. USA. 2011;108:19389-19394. [PMID:22084112]
○Eneling K, Brion L, Pinto V, Pinho MJ, Sznajder JI, Mochizuki N, Emoto K, Soares-da-Silva P and Bertorello AM. Salt-inducible kinase 1 regulates E-cadherin expression and intercellular junction stability. FASEB J. 2012;in press [PMID:22522110]

妻木チーム
○Hiramatsu K, Sasagawa S, Outani H, Nakagawa K, Yoshikawa H and Tsumaki N. Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors. J Clin Invest. 2011;121:640-657. [PMID:21293062]
○Hiramatsu K, Iwai T, Yoshikawa H and Tsumaki N. Expression of dominant negative TGFbeta receptors inhibits cartilage formation in conditional transgenic mice. J. Bone Miner Metab. 2011;29(4):493-500. [PMID:21213115]
○Ikegami D, Iwai T, Ryo SI, Gu N, Sugiyama T, Oh I, Yoshikawa H and Tsumaki N. Identification of small molecular compounds and fabrication of its aqueous solution by laser-ablation, expanding primordial cartilage. Osteoarthritis Cartilage. 2011;19:233-241. [PMID:21094690]
○Ikegami D, Akiyama H, Suzuki A, Nakamura T, Nakano T, Yoshikawa H and Tsumaki N. Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development. 2011;138:1507-1519. [PMID:21367821]
○Outani H, Okada M, Hiramatsu K, Yoshikawa H and Tsumaki N. Induction of chondrogenic cells from dermal fibroblast culture by defined factors does not involve a pluripotent state. Biochem. Biophys. Res. Co. 2011;411:607-612. [PMID:21763273]
○Nakamura Y, Yamamoto K, He X, Otsuki B, Kim Y, Murao H, Soeda T, Tsumaki N, Deng JM, Zhang Z, Behringer RR, Crombrugghe B, Postlethwait JH, Warman ML, Nakamura T and Akiyama H. Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nat Commun. 2011;2:251. [PMID:21427722]
○Sasagawa S, Takemori H, Uebi T, Ikegami D, Hiramatsu K, Ikegawa S, Yoshikawa H and Tsumaki N. SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice. Development. 2011;139:1153-1163. [PMID:22318228]
○Okamoto M, Murai J, Imai Y, Ikegami D, Kamiya N, Kato S, Mishina Y, Yoshikawa H and Tsumaki N. Conditional deletion of Bmpr1a in differentiated osteoclasts increases osteoblastic bone formation, increasing volume of remodeling bone in mice. J. Bone Miner. Res. 2011;26:2511-2522. [PMID:21786321]

西田チーム
○Imajo M and Nishida E. Human Tribbles homolog 1 functions as a negative regulator of retinoic acid receptor. Genes Cells 2010;15:1089-1097. [PMID:21053424]
○Endo T, Kusakabe M, Sunadome K, Yamamoto T and Nishida E. The kinase SGK1 in the endoderm and mesoderm promotes ectodermal survival by downregulating components of the death-inducing signaling complex. Science Signaling. 2011;4:ra2. [PMID:21245468]
○Sunadome K, Yamamoto T, Ebisuya M, Kondoh K, Sehara-Fujisawa A and Nishida E. ERK5 regulates muscle cell fusion through Klf transcription factors. Dev. Cell. 2011;20:192-205. [PMID:21316587]
○Imajo M, Miyatake K, Iimura A, Miyamoto A and Nishida, E. A molecular mechanism that links Hippo signalling to the inhibition of Wnt/beta-catenin signalling. EMBO J. 2012;31:1109-1122. [PMID:22234184]
○Matsumura S, Hamasaki M, Yamamoto T, Ebisuya M, Sato M, Nishida E and Toyoshima F. ABL1 regulates spindle orientation in adherent cells and mammalian skin. Nature Commun. 2012;3:626. [PMID:22252550]

花園チーム
○Abe T, Masuda S, Ban H, Hayashi S, Inoue M, Hasegawa M, Nagao Y and Hanazono Y. Ex vivo expansion of human HSCs with Sendai virus vector expressing HoxB4 assessed by sheep in utero transplantation. Exp. Hematol. 2011;39(1):47-54.[PMID:20875838]
○Abe T, Masuda S, Tanaka Y, Nitta S, Kitano Y, Hayashi S, Hanazono Y and Nagao Y. Maternal administration of busulfan before in utero transplantation of human hematopoietic stem cells enhances engraftments in sheep. Exp. Hematol. 2012;39(1):47-54. [PMID:22306296]

宮島チーム
○Miyaoka Y, Kato H, Ebato K, Saito S, Miyata N, Imamura T and Miyajima A. Retention in the Golgi apparatus and expression on the cell surface of Cfr/Esl-1/Glg-1/MG-160 are regulated by two distinct mechanisms. Biochem. J. 2011;44:33-41. [PMID:21777203]
○Tsukahara Y, Tanaka M and Miyajima A. TROP2 expressed in the trunk of the ureteric duct regulates branching morphogenesis during kidney development. PLoS One. 2011;6:e28607. [PMID:22194864]
○Hirose Y, Saijou E, Sugano Y, Takeshita F, Nishimura S, Nonaka H, Chen YR, Sekine K, Kido T, Nakamura T, Kato S, Kanke T, Nakamura K, Nagai R, Ochiya T and Miyajima A. Inhibition of Stabilin-2 elevates the circulating hyaluronic acid level and prevents tumor metastasis. Proc. Natl. Acad. Sci. USA. 2012;109:4263-4268. [PMID:22371575]
○Evenou F, Hamon M, Fujii T, Takeuchi S and SakaiY. Gas-permeable membranes and co-culture with fibroblasts enable high-density hepatocyte culture as multilayered liver tissues. Biotechnol. Prog. 2011;27(4):1146-1153. [PMID:21630487]
○Murakami Y, Toyoda H, Tanaka M, Kuroda M, Harada Y, Matsuda F, Tajima A, Kosaka N, Ochiya T and Shimotohno K. The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families. PLoS One. 2011;6:e16081. [PMID:21283674]
○Ishikawa T, Hagiwara K and Ochiya T. Generaton and Hepatic Differentiation of Human iPS Cells. Methods Mol Biol. 2012;826:103-114. [PMID:22167643]

山村チーム
○Ono A, Hattori S, Kariya R, Iwanaga S, Taura M, Harada H, Suzu S and Okada S. Comparative study of human hematopoietic cell engraftment into Balb/c and C57BL/6 strain of Rag-2/Jak3 double-deficient mice. J Biomed Biotechnol 2011;539748. [PMID:21331358]
○Li Z, Zhao G, Shen J, Araki K,, Haruna K, Inoue S, Wang J and Yamamura K. Enhanced expression of human cDNA by phosphoglycerate kinase promoter-puromycin cassette in the mouse transthyretin locus. Transgenic Res. 2011;20:191-200. [PMID:20369382]
○Shiraki N, Yamazoe T, Qin Z, Ohgomori K, Mochitate K, Kume K and Kume S. Efficient Differentiation of Embryonic Stem Cells into Hepatic Cells In Vitro Using a Feeder-Free Basement Membrane Substratum. PLoS One. 2011;6:e24228. [PMID:21887386]
○Kurokawa J, Nagano H, Ohara O, Kubota N, Kadowaki T, Arai S and Miyazaki T. AIM is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue. Proc. Natl. Acad. Sci. USA. 2011;108:12072-12077. [PMID:21730133]

吉田チーム
○Iwasa E, Hamashima Y, Fujishiro S, Higuchi E, Ito A, Yoshida M and Sodeoka M. Total synthesis of (+)-chaetocin and its analogs: Their histone methyltransferase G9a inhibitory activity. J. Am. Chem. Soc. 2010;132:4078-4079. [PMID:20210309]
○Ito T, Umehara T, Sasaki K, Nakamura Y, Nishino N, Terada K, Shirouzu M, Padmanabhan B, Yokoyama S, Ito S and Yoshida M. Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors. Chem. Biol. 2011;18(4):495-507. [PMID:21513886]
○Takahashi M, Takemoto Y, Shimazu T, Kawasaki H, Tachibana M, Shinkai Y, Takagi M, Shin-Ya K, Igarashi Y, Ito A and Yoshida M. Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines. J. Antibiot. 2012; in press [PMID:22334240]
○Sun Y, Takada K, Takemoto Y, Yoshida M, Nogi Y, Okada S and Matsunaga S. Gliotoxin analogues from a marine-derived fungus, Penicillium sp., and their cytotoxic and histone methyltransferase inhibitory activities. J. Nat. Prod. 2012;75(1):111-114. [PMID:22148349]
○Furumai R, Ito A, Ogawa K, Maeda S, Saito A, Nishino N, Horinouchi, S and Yoshida M. Histone deacetylase inhibitors block NF-κB?dependent transcription by interfering with RNA polymerase II recruitment. Cancer Sci. 2011;102(5):1081-1087. [PMID:21299717]
○Hori A, Yoshida M and Feng Ling F. Mitochondrial fusion increases the mitochondrial DNA copy number in budding yeast. Genes Cells. 2011;16(5):527-544. [PMID:21463454]
○Bradshaw E, Yoshida M and Ling F. Mitochondrial fission proteins Fis1 and Mdv1, but not Dnm1, play a role in maintenance of heteroplasmy in budding yeast. FEBS Lett. 2012;586:1245-1251.