- JST Home
- /
- Strategic Basic Research Programs
- /
- CREST
- /
- Research Area/Projects/
- Completed/
- [Biodynamics] Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics
※ Affiliations and titles are as of the end of the research activity.
Creation of the technology systems to have absolute control of cells and cell populations by reproducing cell kinetics in silico/in vitro in order to achieve an integrated understanding of life phenomena and realize safe and highly effective treatments among other benefits
Living organisms are in dynamical balance between their responses to environmental stimuli and their ability of maintaining homeostasis. Through observation, experimentation and measurement of biological phenomena conducted by macromolecules including chromosomes, proteins, and lipids at levels of cell-free system, cells and cell populations, the researches of this research area is expected to gain an integrated understanding of dynamical balance of the living organisms in both spatial and temporal dimensions. At the same time, the research of this research area aim to create technologies that can control biological phenomena.
The research should elucidate an operating principle of dynamic and complex biological phenomena that has been hard to address by traditional approaches. To do so, the research needs to utilize rapidly growing high-speed/super-resolution technologies for measurement/analysis, and to integrate life sciences with cutting edge fields of mathematics, physics, chemistry, engineering, information science and computer sciences. We promote leading researches with interdisciplinary views for comprehensive understanding of dynamic systems of the living organisms using modeling and simulation based on mathematical science.
The logo of CREST Biodynamics
Design concept
This round, blue and yellow logo symbolizes the challenges that approximates and expresses the nonlinearity and the hierarchy of a biological dynamics, and consequently, enabling control and design of the regulatory mechanisms of biological phenomena.
・Tetsu AKIYAMA
Professor, The University of Tokyo
・Kiyoshi ASAI
Professor, The University of Tokyo
・Yoh IWASA
Professor, Kwansei Gakuin University
・Tsuyoshi KATO
Professor, Kyoto University
・Takashi SUZUKI
Professor, Osaka University
・Shoji TAKADA
Professor, Kyoto University
・Tadaomi TAKENAWA
Adjunct professor, Kobe University
・Hiroyoshi TOYOSHIBA
Senior Researcher, FRONTEO, Inc.
・Akihiko NAKANO
Deputy Director, RIKEN Center for Advanced Photonics (RAP)
・Shin-Ichi NISHIKAWA
Advisor, JT Biohistory Research Hall / NPO All About Science Japan
・Kiyoko FUKAMI
Professor, Tokyo University of Pharmacy and Life Sciences
・Hisao HONDA
Adjunct professor, Kobe University
・Masayoshi MISHINA
Professor, Ritsumeikan University
・Yoshikazu YOSHIDA
Corporate Adviser, SHIMADZU Corp.
Research Director:
Yuichi Iino(Professor, The University of Tokyo)
Research Director:
Ryoichiro Kageyama(Professor, Kyoto University)
Temporal coding of cellular dynamical system
Research Director:
Sinya Kuroda(Professor, The University of Tokyo)
Research Director:
Minoru S.H. Ko(Professor, Keio University)
Research Director:
Shigeru Kondo(Professor, Osaka University)
Memory integration process based on cell assembly and neural circuit model
Research Director:
Kaoru Inokuchi(Professor, University of Toyama)
Research Director:
Hiroki Kurihara (Professor, The University of Tokyo)
Understanding and Predicting 3D Chromatin Dynamics
Research Director:
Hiroyuki Takeda (Professor, The University of Tokyo)
Research Director:
Sachiko Tsukita (Professor, Osaka University)
Mechanics of generating and sensing flow by cilia
Research Director:
Hiroshi Hamada (Director, RIKEN Center for Biosystems Dynamics Research)
Solving complex network systems based on theories to connect structure and dynamics
Research Director:
Atsushi Mochizuki (Professor, Kyoto University)
Research Director:
Sotaro Uemura (Professor, Graduate School of Science, The University of Tokyo)
Understanding synapse dynamics through nanoscale structural analyses
Research Director:
Shigeo Okabe (Professor, Graduate School of Medicine, The university of Tokyo)
Chronometabolism: Molecular analysis of biological timing
Research Director:
Hitoshi Okamura (Professor, Graduate School of Pharmaceutical Sciences, Kyoto University)
Spontaneous pattern formation ex vivo
Research Director:
Takashi Miura (Professor, Graduate School of Medical Sciences, Kyushu University)