Structure Control and Function Programmed build-up of nano-structures and search for their functions
Research area in the strategic sector PRESTO
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Phase 1 (2005-2008) Phase 2 (2006-2009) Phase 3 (2007-2010)        
Megumi Akai Kenichiro Itami Masayuki Inoue Masato Katahira Kenji Kobayashi Ken-ichi Saitow Hiroshi Sakaguchi
Takeshi Serizawa Atsushi Takano Donglin Jiang Akihiko Tsuda Shuichi Hiraoka Yasujiro Murata Tetsuro Murahashi
Masayuki Inoue
Total Chemical Synthesis and Rational Design of Voltage-sensitive Ion Channel
(Professor, The University of Tokyo, Graduate School of Pharmaceutical Sciences)
Masayuki Inoue
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Voltage-sensitive channels are the highly functional nano-devises that control our sensation, emotions, thought and movement in nerve and muscle. Despite the importance, the large-molecular weight (M.W. >100,000) and the chemical instability have impeded the detailed study of its dynamic function. PTA-A is the largest non-ribosomal peptide (M.W. 5000) that forms a stable voltage-sensitive trans-membrane pore. Our goals of the project are to construct the general synthetic route to PTA-A, to understand its channel function, and to control the dynamic behavior. These studies will be the basis of new design principle of the biomimetic nano-devises.
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