Structure Control and Function Programmed build-up of nano-structures and search for their functions
Research area in the strategic sector PRESTO
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Phase 1 (2005-2008) Phase 2 (2006-2009) Phase 3 (2007-2010)        
Yasuhiro Ishida Rika Iwaura Toshiya Okazaki Hidetoshi Kawai Shiro Komba Satoshi Takamizawa Masateru Taniguchi
Takashi Nakanishi Hamura Toshiyuki Hiromitsu Maeda Miho Yamauchi Ryo Yoshida Yasujiro Murata Tetsuro Murahashi
Hidetoshi Kawai
Hidetoshi Kawai
Development of Cooperative Self-Assembling Method using Allosteric Regulator Molecules for Construction of the Desired Structure in the Desired Place
(Assistant Professor, Hokkaido University, Faculty of Science)
http://barato.sci.hokudai.ac.jp/~org1/
Formation of biological supramolecular polymers based on a cooperative nucleation-growth process is attractive mechanism for construction of a desired structure at a desired place. In this study, I aim to construct the allosteric regulator molecules, whose initial binding of a guest molecule promotes a subsequent guest binding, and the cooperative supramolecular polymers, showing the nucleation-growth process, whose initial dimerization promotes chain-propagation into a long filament. Furthermore, I develop to the controls of the mobility/stability of the supramolecular polymer by incorporating the dynamic covalent bonds into the supramolecular system.
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