Research Director

Toshiaki Isobe
Tokyo Metropolitan University
Professor

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Outline

This study aims to maximize the performance of our state-of-the-art technology based on biological mass spectrometry for the “ribonucleoproteomic” analysis of RNA-protein interaction and its application to the discovery and structure-function studies of novel ribonucleoprotein complexes responsible for human refractory RNA-dysmetabolic syndrome. Our study will provide an innovative tool for the global analysis of cellular function of RNA-protein interaction networks and open up a new dimension for structural life science research, which elucidates the pathogenesis of RNA-dysmetabolic syndrome and facilitates the new drug discovery.