Research Director

Akihito Yamaguchi

Osaka University
Professor
website

Outline

Efflux transporter-based multidrug resistance of pathogenic bacteria is a serious problem of our modern chemotherapy. We determined the world-first crystal structure of a bacterial multidrug efflux transporter in 2002. This project aims to reveal the molecular mechanism of multidrug recognition on the basis of complete structures of multidrug efflux transporter complex and molecular dynamics analysis. In addition, we aim to develop clinically-useful inhibitors against multidrug transporters by structure-based drug design.