Kyoko Shirakabe
Lecturer,Center of Integrated Medical Research,Keio University

Shedding is a post-translational modification mechanism, by which the extracellular domain of membrane-anchored proteins is liberated through their juxtamembrane processing.

As a result of this processing, shedding can regulate not only the activity of membrane proteins but also the function of the cell expressing these proteins.

In this study, I would like to identify shedding target membrane proteins in physiological conditions using proteomic comprehensive screening, and reveal new physiological roles and regulatory mechanisms of shedding.