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Basic Technologies for Controlling Cell Functions Based on Metabolic Regulation Mechanism Analysis

Research Supervisor
Masahiro Nishijima
President,The Pharmaceutical Society of Japan / Professor,Showa Pharmaceutical University
Year Started


The area of this research covers studies on new base technologies of cell regulation for the improvement, modification, and addition of cellular functions and for the restoration of disrupted homeostasis by systematic or comprehensive analyses of metabolic changes in cells and by the elucidation of maintenance mechanism of cellular homeostasis. More concretely, it covers studies on the alteration of intracellular states of normal cells in response to external stimuli by various metabolites and their pathological states, the evaluation and classification of cellular states during development, cell modeling and the prediction of functional changes based on available or individual measurement data, and the prediction of compounds and designs of regulatory substances based on the studies that specifically regulate metabolic pathways. In addition, it covers preparation techniques for cells with novel functions based on these studies.

Strategic Sector

Establishment of Basic Technologies for Controlling of Cell Functions Based on Metabolic Regulation Mechanism Analysis

Research Projects

Year Started : 2007
Research DirectorAffiliationResearch Project
Kazuhiro Iwai Professor, Osaka University Analyses of Mechanism underlying Metabolism of Iron and its Prosthetic Groups and Iron-related Disorders
Susumu Seino Professor, Kobe University Mechanisms of Regulation of Cell Functions Maintaining Glucose Homeostasis
Masami Yokota Hirai Team Leader, RIKEN Elucidation of Amino Acid Metabolism in Plants based on Integrated Omics Analyses
Masayuki Miura Professor, The University of Tokyo Genetic and Biochemical Study of Stress Responses Mediated by Metabolites
Year Started : 2006
Research DirectorAffiliationResearch Project
Hiroyuki Arai Professor, The University of Tokyo Elucidation of the Significance of Phospholipids Molecular Species in Biological Membranes
Toshiaki Isobe Professor, Tokyo Metropolitan University Development of Mass Spectrometry-based Analytical Platform of Small RNAs
Yo-ichi Nabeshima President, Institute of Biomedical Research and Innovation, Fundation for Biomedical Research and Innovation The Study of Novel Mechanism Governing the Energy Metabolism of Animals
Yukio Fujiki Professor, Kyusyu University Metabolism-based Regulation of Organelle Homeostasis and Cell Function
Tetsuro Mimura Professor, Kobe University Control of Plant Metabolic System by Engineering of Vacuolar Membrane Proteins
Year Started : 2005
Research DirectorAffiliationResearch Project
Yoshiya Oda President, Eisai Co., Ltd. Development of Quantitative Metabolomics and Intergration of Metabolome Data with Proteome Data
Ryo Taguchi Professor, Chubu University Construction of the Fundamental System for Lipid Metabolomics and Its Application
Atsushi Hirao Professor, Kanazawa University Investigating the Mechanisms of Cellular Metabolism in Regulating Stem Cell Functions
Shuichi Yanagisawa Associate Professor, The University of Tokyo Molecular basis of Metabolic Regulation by Nutrient Signals in Plants
Mitsuhiro Yanagida Investigator (Professor extraordinary) , Kyoto University Molecular Network that Supports Chromosome Segregation Metabolism
Minoru Yoshida Chief Scientist, RIKEN Global Analysis of Dynamics and Network of Protein Modifications
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