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Basic Technologies for Controlling Cell Functions Based on Metabolic Regulation Mechanism Analysis

Research Supervisor: Masahiro Nishijima
Affiliation: President,The Pharmaceutical Society of Japan / Professor,Showa Pharmaceutical University
Year Started: 2005

Outline

The area of this research covers studies on new base technologies of cell regulation for the improvement, modification, and addition of cellular functions and for the restoration of disrupted homeostasis by systematic or comprehensive analyses of metabolic changes in cells and by the elucidation of maintenance mechanism of cellular homeostasis. More concretely, it covers studies on the alteration of intracellular states of normal cells in response to external stimuli by various metabolites and their pathological states, the evaluation and classification of cellular states during development, cell modeling and the prediction of functional changes based on available or individual measurement data, and the prediction of compounds and designs of regulatory substances based on the studies that specifically regulate metabolic pathways. In addition, it covers preparation techniques for cells with novel functions based on these studies.

Strategic Sector

Establishment of Basic Technologies for Controlling of Cell Functions Based on Metabolic Regulation Mechanism Analysis

Research Projects

Year Started : 2007
Research Director	Affiliation	Research Project
Kazuhiro Iwai	Professor, Osaka University	Analyses of Mechanism underlying Metabolism of Iron and its Prosthetic Groups and Iron-related Disorders
Susumu Seino	Professor, Kobe University	Mechanisms of Regulation of Cell Functions Maintaining Glucose Homeostasis
Masami Yokota Hirai	Team Leader, RIKEN	Elucidation of Amino Acid Metabolism in Plants based on Integrated Omics Analyses
Masayuki Miura	Professor, The University of Tokyo	Genetic and Biochemical Study of Stress Responses Mediated by Metabolites

Year Started : 2006
Research Director	Affiliation	Research Project
Hiroyuki Arai	Professor, The University of Tokyo	Elucidation of the Significance of Phospholipids Molecular Species in Biological Membranes
Toshiaki Isobe	Professor, Tokyo Metropolitan University	Development of Mass Spectrometry-based Analytical Platform of Small RNAs
Yo-ichi Nabeshima	President, Institute of Biomedical Research and Innovation, Fundation for Biomedical Research and Innovation	The Study of Novel Mechanism Governing the Energy Metabolism of Animals
Yukio Fujiki	Professor, Kyusyu University	Metabolism-based Regulation of Organelle Homeostasis and Cell Function
Tetsuro Mimura	Professor, Kobe University	Control of Plant Metabolic System by Engineering of Vacuolar Membrane Proteins

Year Started : 2005
Research Director	Affiliation	Research Project
Yoshiya Oda	President, Eisai Co., Ltd.	Development of Quantitative Metabolomics and Intergration of Metabolome Data with Proteome Data
Ryo Taguchi	Professor, Chubu University	Construction of the Fundamental System for Lipid Metabolomics and Its Application
Atsushi Hirao	Professor, Kanazawa University	Investigating the Mechanisms of Cellular Metabolism in Regulating Stem Cell Functions
Shuichi Yanagisawa	Associate Professor, The University of Tokyo	Molecular basis of Metabolic Regulation by Nutrient Signals in Plants
Mitsuhiro Yanagida	Investigator (Professor extraordinary) , Kyoto University	Molecular Network that Supports Chromosome Segregation Metabolism
Minoru Yoshida	Chief Scientist, RIKEN	Global Analysis of Dynamics and Network of Protein Modifications

Research Area Website: http://www.cellmetabo.jst.go.jp/en/index.html