Research Project Outline
How the number of chromosomes (46 for human, for example) is kept to be constant? This project will elucidate cellular functions of molecular network that is essential for homeostasis of chromosome number. Metabolic regulatory pathways consisting of evolutionarily conserved proteins and metabolites exist and are required for inheriting chromosomes. We will establish the pathways using a variety of integrated technologies. Knowledge obtained and methodology developed will be applicable in principle to any organisms, so that their values are high and expected to be applicable in the areas of understanding the causes of 'chromosome diseases' and cancer.
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