Genetic and Biochemical Study of Stress Responses Mediated by Metabolites

Research Project Outline

We have received various stresses that include infection, injury and starvation during development, growth and aging. Caspases are activated under various stress conditions and are thought to be critical stress sensing proteins. In this research, we will identify metabolites that activate caspases upon stress conditions and will study the stress responsible metabolites that are produced from caspase activated cells by biochemical and genetic approaches. Our research goal is to provide a novel insight of in vivo response of stress and maintenance of homeostasis under stress conditions.