Research Project Outline
The energy metabolism in animals is regulated by the coordination of multistage events, i.e. intestinal uptake of nutrients, their metabolism in the body, and inter- and intra-cellular signaling generated by those metabolites. Beta-Klotho we identified is estimated to be an important regulator of energy metabolism. Our final goal is to clarify the molecular function of beta-Klotho and to expand our comprehensive understanding of the energy metabolism. As energy metabolism forms the background of obesity, aging and metabolic syndromes, our results may contribute to the clinical application of these diseases.